Stem Cells

Mitochondria emerge as an important regulator of cell fate during the development. Multiple mechanisms have been proposed, such as, ROS elicited DNA-damage response, or mitochondrial metabolites for growth and epigenetic modifications. Our studies seek to identify and target mitochondrial mechanisms for promoting the maturation of cells derived from human induced pluripotent stem cells (iPSC).

Dai Stem Cells Int 2017;
Lee, Cao Circ Res 2018