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CONTACT Email : yeonjink@uw.edu
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ACTING ASSISTANT PROFESSOR Dacey Lab (Dacey Lab Website) Research Focus: Retinal circuitry and vision RESEARCH Retinal electrophysiology and Connectomics: The human visual process is initiated in an extremely complex neural circuitry that begins at the very first synapse in the neural retina from photoreceptors to bipolar cell interneurons. We now know that the retina comprises nearly 100 different neural cell types which interact to create over 20 separate and parallel visual pathways, or information channels, from the eye to the brain. Characterizing this circuitry and understanding how these circuits create the different neural signals related to the perception of form, color and motion is a fundamental problem in visual neuroscience. In my current postdoc we are addressing these questions directly in the human retina and in the closest model for the human retina, the macaque monkey. To address these, I employ the 4 different techniques, electrophysiology, 2-photon calcium imaging, connectomics, and neural modeling. Vision and cognitive neuroscience: The goal of this research was to advance understanding how real-world (natural scene) visual information is encoded within the human brain and perceived by the human observer. The natural scene is composed both color and luminance contrast at different sizes and orientations. Much of our understanding of visual processing, however, comes from studies focusing on the aspect of color alone or luminance alone. I am interested in studying the interactions between color and luminance contrast that occurs in everyday viewing of the world. To study these, I employ the behavioral testing of human vision (psychophysics), brain stimulation (TMS), and computational modeling.
SELECTED ABSTRACTS AND PUBLICATIONS Kim, Y.J., Packer, O., Pollreisz, A., Martin, R. P., Grünert, U., & Dacey, D.M. (2023). Comparative connectomics reveals non-canonical wiring for color vision in human foveal retina. Proceedings of the National Academy of Sciences of the USA, 120 (18) e2300545120. https://doi.org/10.1073/pnas.230054512. PDF Kim, Y.J., Peterson, B.B., Crook, J., Joo, H.R., Wu, J.J., Puller, C., Robinson, F.R., Gamlin, P.D., Yau, K.W.,Troy, J.B., Smith, R.G., Packer, O., Detwiler, P.B., & Dacey, D.M. (2022). Origins of direction selectivity in the primate retina. Nature Communications, 13: 2862. PDF Zhang, C., Kim, Y.J., Silverstein, A., Hoshino, A., Reh, T., Dacey, D.M., & Wong, R.O. (2020). Circuit reorganization shapes the developing human foveal midget connectome towards single-cone resolution. Neuron, 108, 1-14. https://doi.org/10.1016/j.neuron.2020.09.014. PDF Kim, Y.J., Packer, O.S., Detwiler, P.B., & Dacey, D.M. (2019). Achromatic contrast adaptation parasol and midget ganglion cells of the macaque monkey retina. Investigative Ophthalmology & Visual Science, 60(9), 5276. PDF Kim, Y.J., Reynaud, A., Hess, R.F., & Mullen, K.T. (2017). A normative dataset for the clinical assessment of achromatic and chromatic contrast sensitivity using a qCSF approach. Investigate Opthalmology & Visual Science, 58(9), 3628-3636. PDF Kim, Y.J. & Mullen, K.T. (2016). Effect of overlaid luminance contrast on perceived color contrast: shadows enhance, borders suppress. Journal of Vision, 16(11):15, 1-14. PDF Kim, Y.J. & Mullen, K.T. (2015). The dynamics of cross-orientation masking at monocular and dichoptic sites. Vision Research, 116, 80-91. PDF Kim, Y.J., Gheiratmand, M., & Mullen, K.T. (2013). Cross-orientation masking in human color vision: Application of a two-stage model to assess dichoptic and monocular sources of suppression. Journal of Vision, 13(6):15, 1-14. PDF
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