May 6, 2022

Two Articles in PNAS Provide New Insights on Surface-Bound Protein Assembly and Templated Mineralization

Two independent reports led by Dr. Shuai Zhang and Susrut Akkineni were published in the Proceedings of the National Academy of Sciences of the USA. In the first study, high-speed atomic force microscopy (AFM) images of rod-like proteins were analyzed by machine learning and simulations to reveal the dynamics of their rotation on a mica surface. Susrut, a graduate student in the De Yoreo Group, further studied how calcium phosphate nucleation is facilitated by amyloid analogs using in-situ AFM and simulations.

Read the full articles here:

Zhang, et al. Rotational dynamics and transition mechanisms of surface-adsorbed proteins. https://doi.org/10.1073/pnas.2020242119

Akkineni, et al. Amyloid-like amelogenin nanoribbons template mineralization via a low-energy interface of ion binding sites. https://doi.org/10.1073/pnas.2106965119