Selected Peer-Reviewed Publications
1: Deng X, Ma W, Ramani V, Hill A, Yang F, Ay F, Berletch JB, Blau CA, Shendure J, Duan Z, Noble WS, Disteche CM. Bipartite structure of the inactive mouse X chromosome. Genome Biol. 2015 Aug 7;16:152. doi: 10.1186/s13059-015-0728-8.
PubMed PMID: 26248554; PubMed Central PMCID: PMC4539712.
2: Yang F, Deng X, Ma W, Berletch JB, Rabaia N, Wei G, Moore JM, Filippova GN, Xu J, Liu Y, Noble WS, Shendure J, Disteche CM. The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation. Genome Biol. 2015 Mar 12;16:52. doi: 10.1186/s13059-015-0618-0.
PubMed PMID: 25887447; PubMed Central PMCID: PMC4391730.
3: Berletch JB, Ma W, Yang F, Shendure J, Noble WS, Disteche CM, Deng X. Escape from X inactivation varies in mouse tissues. PLoS Genet. 2015 Mar 18;11(3):e1005079. doi: 10.1371/journal.pgen.1005079. eCollection 2015 Mar.
PubMed PMID: 25785854; PubMed Central PMCID: PMC4364777.
4: Deng X, Berletch JB, Nguyen DK, Disteche CM. X chromosome regulation: diverse patterns in development, tissues and disease. Nat Rev Genet. 2014 Jun;15(6):367-78. doi: 10.1038/nrg3687. Epub 2014 Apr 15. Review.
PubMed PMID: 24733023; PubMed Central PMCID: PMC4117651.
5: Berletch JB, Deng X, Nguyen DK, Disteche CM. Female bias in Rhox6 and 9 regulation by the histone demethylase KDM6A. PLoS Genet. 2013 May;9(5):e1003489. doi: 10.1371/journal.pgen.1003489. Epub 2013 May 2.
PubMed PMID: 23658530; PubMed Central PMCID: PMC3642083.
6: Deng X, Berletch JB, Ma W, Nguyen DK, Hiatt JB, Noble WS, Shendure J, Disteche CM. Mammalian X upregulation is associated with enhanced transcription initiation, RNA half-life, and MOF-mediated H4K16 acetylation. Dev Cell. 2013 Apr 15;25(1):55-68. doi: 10.1016/j.devcel.2013.01.028. Epub 2013 Mar 21.
PubMed PMID: 23523075; PubMed Central PMCID: PMC3662796.
7: Disteche CM. Dosage compensation of the sex chromosomes. Annu Rev Genet. 2012;46:537-60. doi: 10.1146/annurev-genet-110711-155454. Epub 2012 Sep 4. Review.
PubMed PMID: 22974302; PubMed Central PMCID: PMC3767307.
8: Deng X, Hiatt JB, Nguyen DK, Ercan S, Sturgill D, Hillier LW, Schlesinger F, Davis CA, Reinke VJ, Gingeras TR, Shendure J, Waterston RH, Oliver B, Lieb JD, Disteche CM. Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster. Nat Genet. 2011 Oct 23;43(12):1179-85. doi: 10.1038/ng.948
PubMed PMID: 22019781; PubMed Central PMCID: PMC3576853.
9: Nguyen DK, Yang F, Kaul R, Alkan C, Antonellis A, Friery KF, Zhu B, de Jong PJ, Disteche CM. Clcn4-2 genomic structure differs between the X locus in Mus spretus and the autosomal locus in Mus musculus: AT motif enrichment on the X. Genome Res. 2011 Mar;21(3):402-9. doi: 10.1101/gr.108563.110. Epub 2011 Jan 31.
PubMed PMID: 21282478; PubMed Central PMCID: PMC3044854.
10: Yang F, Babak T, Shendure J, Disteche CM. Global survey of escape from X inactivation by RNA-sequencing in mouse. Genome Res. 2010 May;20(5):614-22. doi: 10.1101/gr.103200.109. Epub 2010 Apr 2.
PubMed PMID: 20363980; PubMed Central PMCID: PMC2860163.
11: Rubio ED, Reiss DJ, Welcsh PL, Disteche CM, Filippova GN, Baliga NS, Aebersold R, Ranish JA, Krumm A. CTCF physically links cohesin to chromatin. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8309-14. doi: 10.1073/pnas.0801273105. Epub 2008 Jun 11.
PubMed PMID: 18550811; PubMed Central PMCID: PMC2448833.
12: Xu J, Deng X, Watkins R, Disteche CM. Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons. J Neurosci. 2008 Apr 23;28(17):4521-7. doi: 10.1523/JNEUROSCI.5382-07.2008. PubMed PMID: 18434530; PubMed Central PMCID: PMC2643472.
13: Nguyen DK, Disteche CM. Dosage compensation of the active X chromosome in mammals. Nat Genet. 2006 Jan;38(1):47-53. Epub 2005 Dec 11.
PubMed PMID: 16341221.
14: Filippova GN, Cheng MK, Moore JM, Truong JP, Hu YJ, Nguyen DK, Tsuchiya KD, Disteche CM. Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Dev Cell. 2005 Jan;8(1):31-42.
PubMed PMID: 15669143.
15: Leppig KA, Sybert VP, Ross JL, Cunniff C, Trejo T, Raskind WH, Disteche CM. Phenotype and X inactivation in 45,X/46,X,r(X) cases. Am J Med Genet A. 2004 Jul 30;128A(3):276-84.
PubMed PMID: 15216549.
16: Tsuchiya KD, Greally JM, Yi Y, Noel KP, Truong JP, Disteche CM. Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse. Genome Res. 2004 Jul;14(7):1275-84. Epub 2004 Jun 14.
PubMed PMID: 15197169; PubMed Central PMCID: PMC442142.
17: Lingenfelter PA, Adler DA, Poslinski D, Thomas S, Elliott RW, Chapman VM, Disteche CM. Escape from X inactivation of Smcx is preceded by silencing during mouse development. Nat Genet. 1998 Mar;18(3):212-3.
PubMed PMID: 9500539.
18: Adler DA, Rugarli EI, Lingenfelter PA, Tsuchiya K, Poslinski D, Liggitt HD, Chapman VM, Elliott RW, Ballabio A, Disteche CM. Evidence of evolutionaryup-regulation of the single active X chromosome in mammals based on Clc4 expression levels in Mus spretus and Mus musculus. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9244-8.
PubMed PMID: 9256467; PubMed Central PMCID: PMC23138.
19: Tsuchiya K, Reijo R, Page DC, Disteche CM. Gonadoblastoma: molecular definition of the susceptibility region on the Y chromosome. Am J Hum Genet. 1995 Dec;57(6):1400-7.
PubMed PMID: 8533770; PubMed Central PMCID: PMC1801429.
20: Rugarli EI, Adler DA, Borsani G, Tsuchiya K, Franco B, Hauge X, Disteche C, Chapman V, Ballabio A. Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice. Nat Genet. 1995 Aug;10(4):466-71.
PubMed PMID: 7670496.