Overview
FishBone 2017 will be a day-long workshop on Friday May 12, 2017 as part of the ECTS Pre-Congress Program. The workshop will begin in the morning and end in the evening, with several breaks in between.
Format
This day-long workshop is open to clinicians, biologists and geneticists dedicated to bone research, with a focus on fish models of human skeletal disease. The workshop seeks to encourage interaction between established and potential fish users and bone researchers from different disciplines. All presenters are encouraged to provide background to bring participants to a basic level of understanding, as well as to present new data.
Final Schedule
May 4, 2017: We have posted our final schedule! See below for specific times of talks and ordering within each session.
| 8:00AM | Registration Open |
| 8:45AM-8:50AM | Welcome |
| 8:50AM-9:30AM | Plenary Talk Fish Bone: more than models of human muscle-skeletal disease Ron Shahar |
| 9:30AM-11:05AM | Session I: Development, Skeletogenesis, and Regeneration |
| 9:30AM-9:50AM | The new bestiary: Systematic genetic analysis revealing mechanisms of skeletogenesis and variation Matthew P Harris, Katrin Henke |
| 9:50AM-10:10AM | Stem cells for tooth replacement: facts or fiction? Ann Huysseune, Christoph Winkler, Wen Hui Tan, Doris W.T. Au , P. Eckhard Witten |
| 10:10AM-10:30AM | Cellular and molecular mechanisms of osteoblast plasticity during zebrafish fin regeneration Ivonne Sehring, Gilbert Weidinger |
| 10:30AM-10:50AM | Function of csf1r paralogues in regulation of osteoclastogenesis and activity in the zebrafish Joana Caetano-Lopes, Katia Urso, Katrin Henke, Julia F Charles, Matthew P Harris |
| 10:50AM-11:05AM | Science Slam: Oral Poster Session I |
| 10:50AM-10:55AM | Screening for osteogenic compounds using the zebrafish as a model Andy Willaert, Charlotte Gistelinck, Hanna De Saffel, Jan Willem Bek, Paul Coucke |
| 10:55AM-11:00AM | Telling good segmentation from bad Rachna Narayanan, Ivan Lengyel, Guillaume Valentin, Laura Lleras-Forero, Stefan Schulte-Merker, Luis Morelli, Andrew Oates |
| 11:00AM-11:05AM | Group Questions |
| 11:05AM-11:30AM | Coffee Break I |
| 11:30AM-1:00PM | Session II: Mechanics, Mineralization, and Mechanobiology |
| 11:30AM-11:50AM | Bone without minerals: The central role of phosphorous in teleost skeletal mineralization Eckhard Witten, Ramon Fontanillas, Ann Huysseune, Charles McGurk, Alex Obach, Matthew A. G. Owen |
| 11:50AM-12:10PM | Development, ultrastructure and mechanics of shark and ray tessellated cartilage, Nature’s curious alternative to bone Mason N Dean, Ronald Seidel, A Jayasankar, Michael Blumer, A Hosny, James Weaver, David Knoetel, Daniel Baum, Peter Fratzl |
| 12:10PM-12:30PM | Retinoic acid signaling is required for segmental notochord sheath ossification during zebrafish vertebral column development Hans-Martin Pogoda, Lea Schneiders, Iris Riedl-Quinkerts, Joshua Waxman, Rodney Dale, Laura Lleras-Forero, Stefan Schulte-Merker, Matthias Hammerschmidt |
| 12:30PM-12:50PM | Lost in evolution: Novel form of modeling bypasses the need for osteocytes in the adaptation of bones to mechanical loading Lior Ofer, Elazar Zelzer, Ron Shahar |
| 1:00PM-1:40PM | Lunch |
| 1:40PM-3:10PM | Session III: Genetics of Musculoskeletal Disease I: Collagens and OI |
| 1:40PM-2:00PM | microCT-based skeletal phenomics in zebrafish reveals virtues of deep phenotyping at the whole-organism scale Matthew Hur, Charlotte Gistelinck, Philippe Huber, Jane Lee, Marjorie Thompson, Adrian Monstad-Rios, Claire Watson, Sarah McMenamin, Andy Willaert, David Parichy, Paul Coucke, Ronald Kwon |
| 2:00PM-2:20PM | Phenomic analysis of zebrafish type I collagen mutants reveals a spectrum of skeletal phenotypes mimicking the clinical variability in human brittle bone disease Charlotte Gistelinck, Ronald Kwon, Fransiska Malfait, Sofie Symoens, Petra Vermassen, Hanna De Saffel, Katrin Henke, Matthew Harris, Anne De Paepe, MaryAnn Weis, David Eyre, Paul Coucke, Andy Willaert |
| 2:20PM-2:40PM | Use of chemical chaperones to target cellular stress in Chihuahua, a zebrafish model of dominant osteogenesis imperfecta Francesca Tonelli, R Gioia, I Ceppi, M Biggioigera, S Fisher, T Schinke, S Leikin, A Rossi, A Forlino |
| 2:40PM-2:55PM | Quantitative 3D‐morphometry of vertebra reveals severe pathological changes in an osteogenesis imperfecta zebrafish model carrying a collagen type I glycine substitution Imke AK Fiedler, Petar Milovanovic, Roberta Gioia, Francesca Tonelli, Katharina Jähn, Antonella Forlino, Björn Busse |
| 2:55PM-3:10PM | Modelling skeletal aspects of Stickler syndrome in zebrafish Elizabeth Lawrence, Karen Roddy, Erika Kague, Chrissy Hammond |
| 3:10PM-3:30PM | Science Slam: Oral Poster Session II |
| 3:10PM-3:15PM | Initial validation of zebrafish as model for Holt-Oram syndrome M Leonor Cancela, Débora Varela, Natércia Conceição |
| 3:15PM-3:20PM | Intramuscular bones of the Atlantic herring fish as a new model to establish the link between mineral-related parameters and micro-mechanical properties at early stages of tissue maturation Imke AK Fiedler, Baptiste Depalle, Andre Duarte, Xizhe Zhao, Luis Cardoso, Shi Jin, Jean-Philippe Berteau |
| 3:20PM-3:25PM | A micro-computed tomography study of lateral plates in threespine stickleback Elisabeth Wiig, Janne Reseland, L Asbjørn Vøllestad, Kjartan Østbye, Håvard Haugen |
| 3:25PM-3:30PM | Group Questions |
| 3:30PM-3:50PM | Coffee Break II |
| 3:50PM-5:05PM | Session IV: Genetics of Musculoskeletal Disease II: Osteoporosis, Osteoarthritis, and Beyond |
| 3:50PM-4:10PM | GPATCH1 and AKAP11 identified by targeted resequencing and evaluation of osteogenic mineralization in zebrafish and MC3T3-E1 cells Vincent KF Cheng, Grace KY Lee, CL Cheung |
| 4:10PM-4:25PM | CRISPR-Cas9 lrp5 knock-out zebrafish as a model for developmental diseases of bone mass Ram Harari, Chen Shochat Carvalho, David Karasik |
| 4:25PM-4:40PM | Basic Helix loop Helix transcription factor twist1a and twist1b and their involvement in the skeletal development of zebrafish Jérémie Zappia, Thomas Windhausen, Jordan Cornet, Joerg Renn, Marc Muller |
| 4:40PM-4:55PM | Ageing zebrafish to model Osteoarthritis Erika Kague, Karen Roddy, Roddy Skinner, Elizabeth Lawrence, Kate Robson-Brown, Chrissy Hammond |
| 5:05PM-5:35PM | Panel Discussion |
| 5:35PM-5:45PM | Student Awards |
| 5:45PM-6:45PM | Poster Session |