The Gao Lab

Publications

Peer reviewed journal publications

  • Y. Han, X.H. Gao, J. Su, and S. Nie, Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules, Nat. Biotechnol. 2001, 19, 631-635.
  • H. Gao, W.C.W. Chan, and S. Nie, Quantum-dot nanocrystals for ultrasensitive biological labeling and multicolor optical encoding, J. Biomed. Optics 2002, 7, 532–537.
  • C.W. Chan, D. Maxwell, X.H. Gao, R.A. Bailey, M.Y. Han, and S. Nie, Luminescent quantum dots for multiplexed biological detection and imaging, Curr. Opin. Biotechnol. 2002, 13, 40-46
  • H. Gao, and S. Nie, Molecular profiling of single cells and tissue specimens with quantum dots, Trends Biotechnol. 2003, 21, 371-373
  • H. Gao, and Shuming Nie, Doping mesoporous materials with multicolor quantum dots, J. Phys. Chem. B 2003, 107, 11575-11578.
  • H. Gao, and Shuming Nie, QD-encoded mesoporous beads with high brightness and uniformity: rapid readout by flow cytometry, Anal. Chem.2004,76, 2406-2410
  • H. Gao, Y.Y. Cui, R. Levenson, L. Chung, and S. Nie, In vivo cancer targeting and imaging with semiconductor quantum dots, Nat. Biotechnol. 2004, 22, 969-976.
  • Smith, X.H. Gao, and S. Nie, Quantum-dot nanocrystals for in-vivo molecular and cellular imaging, Photochem. Photobiol. 2004, 80, 377-385.
  • H. Gao, L. Yang, J.A. Petros, F.F. Marshall, J.W. Simons, L. Chung, and S. Nie, In vivo molecular and cellular imaging with quantum dots, Curr. Opin. Biotechnol. 2005, 16, 63-72
  • M. Smith, S.R. Dave, S. Nie, L. True and X.H. Gao, Multicolor quantum dots for molecular diagnostics of cancer, Expert Rev. Mol. Diagn. 2006, 6, 231-244
  • E. Ferrara, D. Weiss, P.H. Carnell, R.P. Vito, D. Vega, X.H. Gao, S. Nie and W.R. Taylor, Quantitative 3D fluorescence technique for the analysis of en face preparations of arterial walls using quantum dot nanocrystals and two-photon excitation laser scanning microscopy, Am. J. Physiol. 2006, 290, R114-R123.
  • N. Rhyner, A.M. Smith, X.H. Gao, H. Mao, L. Yang and S. Nie, Quantum dots and multifunctional nanoparticles: new contrast agents for tumor Imaging, Nanomedicine 2006, 1, 209-217.
  • V. Yezhelyev, X.H. Gao, Y. Xing, A. Al-Hajj, S. Nie and R.M O’Regan, Emerging use of nanoparticles in diagnosis and treatment of breast cancer, Lancet Oncology 2006, 7, 657-667
  • D. True and X.H. Gao, Quantum dots for molecular pathology-their time has arrived, J. Mol. Diagn. 2007, 9, 7-11
  • V. Yezhelyev, A. Al-Hajj, C. Morris, A.I. Marcus, T. Liu, M. Lewis, C. Cohen, P. Zrazhevskiy, J.W. Simons, A. Rogatko, S. Nie, X.H. Gao and R.M. O’Regan, In situ molecular profiling of breast cancer biomarkers with multicolor quantum dots, Adv. Mater., 2007, 19, 3146–3151.
  • Yang, J. Gunn, S.R. Dave, M. Zhang, Y.A. Wang and X.H. Gao, Ultrasensitive detection and molecular imaging with magnetic nanoparticles, Analyst 2008, 133, 154-160.
  • Qi, and X.H. Gao, Emerging application of quantum dots for drug delivery and therapy,” Expert Opin. Drug Delivery, 2008, 5,263-267.
  • Yang, S.R. Dave, and X.H. Gao, Quantum dot nanobarcodes: epitaxial assembly of nanoparticle-polymer complexes in homogeneous solution, J. Am. Chem. Soc., 2008, 130, 5286-5292.
  • Qi, and X.H. Gao, Quantum dot-amphipol nanocomplex for intracellular delivery and real-time imaging of siRNA, ACS Nano, 2008, 2, 1403-1010.
  • Yezhelyev, L. Qi, R.M. O’Regan, S. Nie, and X. Gao, Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging, J. Am. Chem. Soc., 2008, 130, 9006-9012.
  • L. Yang, H. Mao, Y.A. Wang, Z. Cao, X. Peng, X. Wang, H. Duan, C. Ni, Q. Yuan, G. Adams, M.Q. Smith, W.C. Wood, X.H. Gao, S. Nie, Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imaging, Small, 2009, 5, 235-243.
  • L. Yang, X. Peng, Y.A. Wang, X. Wang, Z. Cao, C. Ni, P. Karna, X. Zhang, W.C. Wood, X.H. Gao, S. Nie, H. Mao, Receptor-targeted nanoparticles for in vivo imaging of breast cancer, Clin. Cancer Res., 2009, 15, 4722-4732.
  • L. Yang, H. Mao, Z. Cao, Y.A. Wang, X. Peng, X. Wang, H.K. Sajja, L. Wang, H. Duan, C. Ni, C.A. Staley, W.C. Wood, X.H. Gao, S. Nie, Molecular imaging of pancreatic cancer in an animal model using targeted multifunctional nanoparticles, Gastroenterology, 2009, 136, 1514-1525.
  • Hu, P. Zrazhevskiy, X.H. Gao, Encapsulation of single quantum dots with mesoporous silica, Ann. Biomed. Eng., 2009, 37, 1960-1966.
  • R. Dave and X.H. Gao, Monodisperse magnetic nanoparticles for biodetection, imaging and drug delivery, a versatile and evolving technology, Wiley Interdisciplinary Reviews: Nanomedicine, 2009, 1, 583-609.
  • Zrazhevskiy and X.H. Gao, Quantum dots for cancer molecular imaging, Minerva Biotecnologica, 2009, 21, 37-52.
  • D. Jin and X.H. Gao, Plasmonic fluorescent quantum dots, Nat. Nanotechnol. 2009, 4, 571-576.
  • Zrazhevskiy and X.H. Gao, Multifunctional quantum dots for personalized medicine, Nano Today, 2009, 4, 414-428.
  • D. Jin and X.H. Gao, Spectrally tunable leakage-free gold nanocontainers, J. Am. Chem. Soc., 2009, 131, 17774–17776.
  • D. Jin , C. Jia , S.W. Huang, M. O’Donnell and X.H. Gao, Multifunctional nanoparticles as coupled contrast agents, Nat. Commun. 2010, 10.1038/ncomms1042.
  • H. Hu and X.H. Gao, Nanocomposites with spatially separated functionalities for combined imaging and magnetolytic therapy, J. Am. Chem. Soc., 2010, 132, 7234-7237.
  • Zrazhevskiy, M. Sena and X.H. Gao, Designing multifunctional quantum dots for bioimaging, detection, and drug delivery, Chem. Soc. Rev. 2010, 39, 4326-4354
  • H. Hu and X.H. Gao, Stable encapsulation of quantum dot barcodes with silica shells, Adv. Func. Mater. 2010, 20, 3721-3726.
  • Hu and X.H. Gao, Silica−polymer dual layer-encapsulated quantum dots with remarkable stability, ACS Nano 2010, 4, 6080-6086.
  • Zorn, S.R. Dave, X.H. Gao, and D. Castner, Method for determining the elemental composition and distribution in semiconductor core-shell quantum dots, Anal. Chem. 2011, 83, 866-873.
  • HY Liu and X.H. Gao, Engineering Monovalent Quantum Dot-Antibody Bioconjugates with a Hybrid Gel System, Bioconjugate Chem. 2011, 22, 510-517.
  • X. Hu and X.H. Gao, Multilayer coating of gold nanorods for combined stability and biocompatibility, Phys. Chem. Chem. Phys. 2011, 13, 10028-10035.
  • E Probst, P. Zrazhevskiy, and X.H. Gao, Rapid multitarget immunomagnetic separation through programmable DNA linker displacement, J. Am. Chem. Soc., 2011, 133, 17126-17129.
  • Bagalkot, and X.H. Gao, siRNA-aptamer chimeras on nanoparticles: preserving targeting functionality for effective gene silencing, ACS Nano, 2011, 5, 8131-8139.
  • H. Hu, S.Y. Chen, and X.H. Gao, Multifunctional nanocapsules for simultaneous encapsulation of hydrophilic and hydrophobic compounds and on-demand release, ACS Nano, 2012, 6, 2558-2565.
  • E. Smith, J. Brownell, C.C. White, Z. Afsharinejad, J. Tsai, X.H. Hu, S.J. Polyak, X.H. Gao, T.J. Kavanagh, D.L. Eaton, In vitro toxicity assessment of amphiphillic polymer-coated CdSe/ZnS quantum dots in two human liver cell models ACS Nano, 2012, 6, 9475-9484
  • Jung, G. Guan, C.W. Wei, R. Reif, X.H. Gao, O’Donnell M, Wang RK. Multifunctional nanoprobe to enhance the utility of optical based imaging techniques, J. Biomed. Opt. 2012, 17(1):016015.
  • Xia, I. Pelivanov, C. Wei, X. Hu, X.H. Gao, M. O’Donnell. Suppression of background signal in magnetomotive photoacoustic imaging of magnetic microspheres mimicking targeted cells, J. Biomed. Opt. 2012, 17(6):061224.
  • Wei, J. Xia, I. Pelivanov, X. Hu, X.H. Gao, M. O’Donnell, Trapping and dynamic manipulation of polystyrene beads mimicking circulating tumor cells using targeted magnetic/photoacoustic contrast agents, J. Biomed. Opt. 2012, 17(10):101517.
  • XG Hu, C.W. Wei, J.J. Xia, I. Pelivanov, M. O’Donnell, X.H. Gao, Trapping and photoacoustic detection of CTCs at the single cell per milliliter level with magneto-optical coupled nanoparticles, Small, 2012, 9, 2046-2052.
  • E. Probst, P. Zrazhevskiy, V. Bagalkot, X.H. Gao, Quantum dots as a platform for nanoparticle drug delivery vehicle design, Adv. Drug Deliv. Rev. 2013, 65, 703-718.
  • J. Qian, X.H. Gao, Triblock copolymer-encapsulated nanoparticles with outstanding colloidal stability for siRNA delivery, ACS Appl. Mater. Interfaces, 2013, 5, 2845-2852.
  • P. Zrazhevskiy, X.H. Gao, Quantum dot imaging platform for single-cell molecular profiling, Nature Communications, doi: 10.1038/ncomms2635, 2013.
  • H. Gao, Molecular Imaging with Multifunctional Nanoparticles, Clin. Chem., 2013, 59, 1532-1533.
  • LA McConnachie, CC White, D Botta, ME Zadworny, DP Cox, RP Beyer, XG Hu, DL Eaton, XH Gao, TJ Kavanagh, Heme oxygenase expression as a biomarker of exposure to amphiphilic polymer-coated CdSe/ZnS quantum dots, Nanotoxicology, 2013, 7, 181-191.
  • CW Wei, J. Xia, I Pelivanov, C Jia, SW Huang, X Hu, H. Gao, and M. O’Donnell, M., Magnetomotive photoacoustic imaging: in vitro studies of magnetic trapping with simultaneous photoacoustic detection of rare circulating tumor cells. J. Biophoton., 2013, 6, 513-522.
  • LA McConnachie, D Botta, CC White, CS Weldy, HW Wilkerson, J. Yu, R. Dills, X. Yu, WC Griffith, EM Faustman, FM Farin, SE Gill, WC Parks, X Hu, H. Gao, D.L. Eaton, T.J. Kavanagh, The glutathione synthesis gene gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot–induced lung inflammation in mice. PLoS ONE 2013, 8, e64165.
  • JW Li, J. Liu, C.W. Wei, B. Liu, M. O’Donnell and X.H. Gao, Emerging applications of conjugated polymers in molecular imaging, Phys. Chem. Chem. Phys., 2013, 15, 17006-17015.
  • Zrazhevskiy, L.D. True, and X.H. Gao, Multicolor multicycle molecular profiling (M3P) with quantum dots for single-cell analysis, Nature Protocols, 2013, 8, 1852-1869.
  • HY Liu, and X.H. Gao, A universal protein tag for delivery of siRNA-aptamer chimeras, Scientific Reports, 2013, 3, DOI: 10.1038/srep03129.
  • O’Donnell, C.W. Wei, J.J. Xia, I. Pelivanov, C.X. Jia, S.W. Huang, X.G. Hu, and X.H. Gao, Can molecular imaging enable personalized diagnostics? an example using magnetomotive photoacoustic imaging, Ann. Biomed. Eng., 2013, 41, 2237-2247.
  • Liu, J.L. Geng, L.D. Liao, N. Thakor, X.H. Gao, B. Liu, Conjugated polymer nanoparticles for photoacoustic vascular imaging, Polymer Chem. 2014, 5, 2854-2862.
  • HY. Liu, P. Zrazhevskiy, X.H. Gao Solid-phase bioconjugation of heterobifunctional adaptors for versatile assembly of bispecific targeting ligands, Bioconjugate Chem. 2014, 25, 1511-1516.
  • J. Shang, X.H. Gao, Nanoparticle counting: towards accurate determination of the molar concentration, Chem. Soc. Rev., 2014, 43, 7267-7278.
  • P. Zrazhevskiy, S.R. Dave; X.H. Gao, Addressing key technical aspects of quantum dot probe preparation for bioassays, Particle & Particle Systems Characterization, 2014, 31, 1291-1299.
  • JW Li, Y. Li, C.Y.K. Chan, R.T.K. Kwok, H. Li, P. Zrazhevskiy, X.H. Gao, J.Z. Sun, A. Qin, and B.Z. Tang, An aggregation-induced-emission platform for direct visualization of interfacial dynamic self-assembly. Angew. Chem. Int. Ed., 2014, 126, 13736-13740.
  • J Shang, X.H. Gao, A living light bulb, ultrasensitive biodetection made easy, Cell and Bioscience, 2014, 4, 34.
  • Lee, R.S. McMahan, X.G. Hu, X.H. Gao, E. M. Faustman, W.C. Griffith, T.J. Kavanagh, D.L. Eaton, J.K. McGuire, W.C. Parks, Amphiphilic polymer-coated CdSe/ZnS quantum dots induce pro-inflammatory cytokine expression in mouse lung epithelial cells and macrophages, Nanotoxicology, 2015, 9, 336-343.
  • J. Shang, X.H. Gao, Leveraging nanotechnology for enrichment of circulating tumor cells in vivo, Nanomedicine, 2015, 10, 2477-2480.
  • J.W. Li, B. Arnal, C.W. Wei, J. Shang, T.M. Nguyen, M. O’Donnell, X.H. Gao, Magneto-optical nanoparticles for cyclic magnetomotive photoacoustic imaging, ACS Nano, 2015, 9, 1964-1976.
  • J. Shang, P. Zrazhevskiy, N. Postupna, C.D. Keene, T.J. Montine, X.H. Gao, Multiplexed in-cell immunoassay for same-sample protein expression profiling, Scientific Reports, 2015, DOI: 10.1038/srep13651
  • M. Ye, C.C. White, Y.H. Jin, X.G. Hu, S. Hayden, X.J. Zhang, X.H. Gao, T.J. Kavanagh, D.T. Chiu, Toxicity and oxidative stress induced by semiconducting polymer dots in RAW264.7 mouse macrophages, Nanoscale 2015, 7, 10085-10093.
  • J.W. Li, S.J. Yoon, B.Y. Hsieh, W. Tai, M. O’Donnell, and X.H. Gao, Stably doped conducting polymer nanoshells by surface initiated polymerization, Nano Lett., 2015, 15, 8217-8222.
  • JW. Li, P. Zrazhevskiy, X.H. Gao, Eliminating size-associated diffusion constraints for rapid on-surface bioassays with nanoparticle probes, Small, 2016, 12, 1035-1043.
  • Arnal, C.W. Wei, J. Li, X.H. Gao and M. O’Donnell, Highly sensitive magneto-motive photoacoustic and ultrasound (PAUS) imaging with cyclic excitations, 2016, J. Opt. 18, 024009.
  • Zorn, S.R. Dave, T. Weidner, X.H. Gao, D.G. Castner, Direct characterization of polymer encapsulated CdSe/CdS/ZnS quantum dots, 2016, Surface Sci, 648, 339-344.
  • P. Zrazhevskiy, S. Akilesh, W. Tai, K. Queitsch, L.D. True, J. Fromm, D. Wu, P. Nelson, J.A. Stamatoyannopoulos, X.H. Gao, Cross-platform DNA encoding for single-cell imaging of gene expression, 2016 Angew. Chem. Int. Ed. 55, 8975-8978.
  • MX. Zhao, J.W. Li, X.H. Gao, Gradient coating of polydopamine via CDR, 2017 Langmuir 33, 6727-6731.
  • Y. Sun, X.H. Gao, Eliminating the animal species constraints in antibody selection for multicolor immunoassays, 2017 Bioconjugate Chem, 28, 1499-1504.
  • MX. Zhao, J.W. Li, X.H. Gao, Eliminating diffusion limitations at the solid liquid interface for rapid polymer deposition, 2017, ACS Biomater. Sci. Eng. 3, 782-786.
  • JW Li, M.A. Baird, M.A. Davis, W. Tai, L.S. Zweifel, K.M. Adams Waldorf, M. Gale Jr, L. Rajagopal, R.H. Pierce, X.H. Gao Dramatic enhancement of the detection limits of bioassays via ultrafast deposition of polydopamine. 2017 Nat. Biomed. Eng. 1, 0082.
  • WY Tai, JW Li, E Corey, XH Gao, A ribonucleoprotein octamer for targeted siRNA delivery, Nature Biomedical Engineering 2, 326-337, 2018
  • HW Lee, XH Gao, YP, Kim, Immuno-nanoparticles for multiplex protein imaging in cells and tissues, Biochip J. 12, 83-92, 2018
  • ZJ Liu, J Zhao, RL Zhang, GM Han, C Zhang, BH Liu, ZP Zhang, MY Han, XH Gao, Cross-platform cancer cell identification using telomerase-specific spherical nucleic acids, ACS Nano 12, 3629-3637, 2018
  • HY Liang, B. Peng, C Dong, LX Liu, JJ Mao, S Wei, XL Wang, HS Xu, J. Shen, HQ Mao, XH Gao, KW Leong, YM Chen, Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation, Nature Commun. 1038/s41467-018-06603-5, 2018
  • ZP Zeng, PF Zhao, L Liu, XH Gao, HQ Mao, YM Chen Lipid stabilized solid drug nanoparticles for targeted chemotherapy, ACS Applied Materials & Interfaces 10, 24969-24974, 2018
  • B Arnal, SJ Yoon, JW Li, XH Gao, M O’Donnell, Magneto-optical nanoparticles for cyclic magnetomotive photoacoustic imaging, Physica C-Superconductivity & Applications, 548, 90-92, 2018
  • KM Adams Waldorf, BR Nelson, JE Stencel-Baerenwald, C Studholme, RP Kapur, B Armistead, CL Walker, S Merillat, J Vornhagen, J Tisoncik-Go, A Baldessari, M Coleman, MK Dighe, DWW Shaw, JA Roby, V Santana-Ufret, E Boldenow, JW Li, XH Gao, MA Davis, JA Swanstrom, K Jensen, DG Widman, RS Baric, JT Medwid, KA Hanley, J Ogle, GM Gough, W Lee, C English, WM Durning, J Thiel, C Gatenby, EC Dewey, MR Fairgrieve, RD Hodge, RF Grant, L Kuller, WB Dobyns, RF Hevner, M Gale Jr, L Rajagopal, Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain, Nature Medicine 24, 368-374 2018
  • W Tai, XH Gao, Noncovalent tagging of siRNA with steroids for transmembrane delivery, Biomaterials 178, 720-727, 2018
  • Scoville DK, White CC, Botta D, An DW, Afsharinejad Z, Bammler TK, Gao XH, Altemeier WA, Kavanagh TJ, Quantum dot induced acute changes in lung mechanics are mouse strain dependent, Inhalation Toxicology 30, 397-403, 2018
  • Synthesis of hybrid magneto-plasmonic nanoparticles with potential use in photoacoustic detection of circulating tumor cells, JG Ovejero, SJ Yoon, JW Li, A Mayoral, XH Gao, M O’Donnell, MA García, P Herrasti, A. Hernando, Microchimica Acta 185, 130, 2018
  • W Tai, XH Gao, Synthetic polymer tag for intracellular delivery of siRNA, Advanced Biosystems, 2, 1800075, 2018
  • W Tai, XH Gao, Ribonucleoprotein: a biomimetic platform for targeted siRNA delivery. Funct. Mater. 2019, 29, 1902221.
  • W Zhou, Y Han, BJ Beliveau, and XH Gao, Combining Qdot nanotechnology and DNA nanotechnology for sensitive single-cell imaging, Adv. Mater. 2020, 32, 1908410
  • W Tai, P Zhao, and XH Gao, Cytosolic delivery of proteins by cholesterol tagging, Science Advances, 2020, 6, eabb0310. DOI: 10.1126/sciadv.abb0310
  • XH Gao, Nanometer puzzle ball, controlled drug release just got more options, 2020, Matter 3, 1827-1828
  • P. Zhao, Y. Han, H. Nguyen, E. Corey, XH Gao, Magneto-endosomalytic therapy for cancer, Adv. Health. Mater, 2021
  • P Zhao, S Liu, AT Koriath, and XH Gao, Partial Magneto-Endosomalysis for cytosolic delivery of antibodies, Bioconjugate Chem. 2022, 33, 2, 363-368.