Phospholipase Reprints
Yun B, Lee H, Powell R, Reisdorph N, Ewing H, Gelb MH, Hsu KL, Cravatt BF, Leslie CC. Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2. Biochem Biophys Res Commun. 2017,. pii: S0006-291X(17)31327-X. doi: 10.1016/j.bbrc.2017.06.195. [Epub ahead of print] PMID: 28684316. Article
Yamamoto, K., Mik,i Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi R., Kambe N., Kabashima K., Lambeau G., Gelb MH., Murakami M. (2015) The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia. J Exp Med. pii: jem.20141904. PMID: 26438362 reprint supplemental
Duchez, A. C., Boudreau, L. H., Bollinger, J., Belleannee, C., Cloutier, N., Laffont, B., Mendoza-Villarroel, R. E., Levesque, T., Rollet-Labelle, E., Rousseau, M., Allaeys, I., Tremblay, J. J., Poubelle, P. E., Lambeau, G., Pouliot, M., Provost, P., Soulet, D., Gelb, M. H., Boilard, E. (2015) Platelet microparticless are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA, Proc. Natl Acad. Sci USA.2015 Jun 23. pii:201507905. [Epub ahead of print]. PMID: 26106157. reprint
Rousseau, M., Naika, G. S., Perron, J., Jacques, F., Gelb, M. H., Boilard, E. (2015) Study of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymus, PLoS One, May 13;10(5):e0126204. doi: 10.1371/journal.pone.0126204.eCollection 2015. PMID: 25969996, PMCID: 4430275. reprint
Rousseau, M., Belleannee, C., Duchez, A.-C., Cloutier, N., Levesque, T., Jacques, F., Perron, J., Nigrovic, P. A., Dieude, M., Hebert, M.-J., Gelb, M. H., Boilard, E. (2015) Detection and quantification of microparticles from different cellular lineages using flow cytometry. Evaluation of the impact of secreted phospholipase A2 on microparticle assessment. POLS ONE, DOI: 10.1371/journal.pone.0116812. PMID: 25587983, PMCID: PMC 4294685. reprint
Boudreau, L. H., Duchez, A.-C., Cloutier, N., Soulet, D., Martin, N., Bollinger, J., Pare, A., Rousseau, M., Naika, G. S., Levesque, T., Laflamme, C., Marcoux, G., Lambeau, G., Farndale, R. W., Pouliot, M., Hamzeh-Cognasse, H., Cognasse, F., Garraud, O., Nigrovic, P. A., Guderley, H., Lacroix, S., Thibault, L., Semple, J. W., Gelb, M. H., and Bollard, E. (2014) Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation, Blood, 124(14):2173-2183. PMID: 25082876, PMCID: PMC4260364. reprint
Sato, H., Taketomi, Y., Ushida, A., Isogai, Y., Kojima, T., Hirabayashi, T., Miki, Y., Yamamoto, K., Nishito, Y., Kobayashi, T., Ikeda, K., Taguchi, R., Hara, S., Ida, S., Miyamoto, Y., Watanabe, M., Baba, H., Miyata, K., Oike, Y., Gelb, M. H., Murakami, M., (2014) The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity, Cell Met., 20:1-14. PMID: 24910243, PMCID: PMC4079757. reprint
Kelvin, A. A., Degousee, N., Banner, D., Stefanski, E., Leon, A. J., Angoulvant, D., Paquette, S. G., Huang, S. S. H., Danesh, A., Robbins, C. S., Noyan, H., Husain, M., Lambeau, G., Gelb, M., Kelvin, D. J., Rubin, B. B. (2014) “Lack of group X secreted phospholipase A2 increases survival following pandemic H1N1 influenza infection,” Virology, 454-455, 78-92. PMID: 24725934, PMCID: PMC4106042 . reprint
Yun, B., Lee, H., Ghosh, M., Cravatt, B. F., Hsu, K. L., Bonventre, J. V., Ewing, H., Gelb, M. H., Leslie, C. C. (2013) Serine hydrolase Inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation, J. Biol Chem., 289:1491-1504, PMID: 24297180, PMCID: PMC3894331. reprint
Bollinger, J. G., Naika, G. S., Sadilek, M., Gelb, M. H. (2013) LC/ESI-MS/MS detection of FAs by charge reversal derivatization with more than four orders of magnitude improvement in sensitivity, J. Lipid Res., 54:3523-3530. PMID: 23945566, PMCID: PMC3826698. reprint
Miki, Y., Yamamoto, K., Taketomi, Y., Sato, H., Shimo, K., Kobayashi, T., Ishikawa, Y., Ishii, T., Nakanishi, H., Ikeda, K., Taguchi, R., Kabashima, K., Arita, M., Arai, H., Lambeau, G., Bollinger, J. M., Hara, S., Gelb, M. H., Murakami, M. (2013) Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators, J. Exp Med., May 20, 2013, 1217-1234. PMID: 23690440, PMCID: PMC3674707. reprint
Taketomi, Y., Ueno, N., Kojima, T., Sato, H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M. Nakamura, M., Nishito, Y., Kawana, M., Kambe, N., Ikeda, K., Taguchi, R., Nakamizo, S., Kabashima, K., Gelb, M. H., Arita, M., Yokomizo, T., Nakamura, M., Watanabe, K., Hirai, H., Nakamura, M., Okayama, Y., Ra, C., Aritake, K., Urade, Y., Morimoto, K., Sugimoto, Y., Shimizu, T., Narumiya, S., Hara, S., Murakami, M. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nature Immunology, 14, 554-563, doi:10.1038/ni.2586 PMID: 23624557, PMCID: PMC4065307. reprint supplemental
Lee, L.K., Bryant, K.J., Bouveret, R., Lei, P.W.,Duff, A.P., Harrop, S.J., Huang, E.P., Harvey, R.P., Gelb, M.H., Gray, P.P., Curmi, P.M., Cunningham, A.M., Church, W.B., Scott, K.F. (2013) Selective inhibition of human group IIA secreted phospholipase A2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes. Journal of Biological Chemistry. PMID: 23482564, PMCID: PMC3663547. reprint
Hallstrand, T. S., Lai, Y., Ni, Z., Oslund, R. C., Henderson, W. R., Gelb, M. H., et al. (2012). Relationship between levels of secreted phospholipase A2 groups IIA and X in the airways and asthma severity. Clinical & Experimental Allergy, 41(6), 801-810. PMID: 21255140, PMCID: PMC3093436. reprint
Sandoval, G., Aloulou, A., Ali, Y., Bezzine, S., Gargouri, Y., & Gelb, M. (2012). Phospholipases: An Overview. In Lipases and Phospholipases (Vol. 861, pp. 63-85): Humana Press. reprint
Henderson, H.R., Ye, X., Lai, Y., Bollinger, J.G., Tien, Y.T., Chi, E.Y., Gelb, M.H. (2012) Key role of group V secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling, PLoS ONE, 8:1-16. PMID: 23451035, PMCID: PMC3581544. reprint
Oslund, R.C., Gelb, M.H. (2012) Biochemical Characterization of Selective Inhibitors of Human Group IIA Secreted Phospholipase A2 and Hyaluronic Acid-Linked Inhibitor Conjugates, Biochemistry, 51: 8617−8626. PMID: 20320658, PMCID: PMC3549043. reprint
Thompson, W., Oslund, R.C., Bollinger, J., Ewing, H., and Gelb, M.H. (2012) “High-Throughput Assay of Secreted Phospholipases A2 Inhibitors.” Chapter 10 in Lipases and Phospholipases: Methods and Protocols, Methods” in Molecular Biology, Vol. 861, (Ed. Georgina Sandoval), pp. 149-158. reprint
Henderson WR Jr, Oslund RC, Bollinger JG, Ye X, Tien YT, Xue J, Gelb MH. (2011) “Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor.” J Biol Chem. 2011 286(32):28049-55. PMID: 21652694 PMCID:3151050 reprint
Hallstrand, T.S., Lai, Y., Henderson, Jr., W.R., Altemeier, W.A., Gelb, M.H. (2011) “Epithelial regulation of eicosanoid production in asthma,” Pulmonary Pharmacology & Therapeutics, 25:432-437. PMID: 23323271, PMCID: PMC3627426. reprint
Yang, J.-S., Valente, C., Polishchuk, R. S., Turacchio, G., Layre, E., Branch Moody, D., et al. (2011). “COPI acts in both vesicular and tubular transport.” Nat Cell Biol, 13(8), 996-1003. PMID: 21725317, PMCID: PMC3179785. reprint
Jemel, I., Ii, H., Oslund, R.C., Payre, C., Dabert-Gay, A.-S., Douguet, D., Chargui, K., Scarzello, S., Gelb, M. H., and Lambeau, G. (2011) “Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells,” J. Biol. Chem., 286:36509-36521. PMID: 21878635, PMCID: PMC3196088. reprint supp.
Bryant, K.J., Bidgood, M.J., Lei, P.W., Taberner, M., Salom, C., Kumar, V., Lee, L., Church, W. B., Courtenay, B., Smart, B. P., Gelb, M. H., Cahill, M.A., Graham, G. G., McNeil, M. P., Scott, K. F. (2011) “A bifunctional role for group IIA secreted phospholipase A2 in human rheumatoid fibroblast-like synoviocyte arachidonic acid metabolism,” J. Biol. Chem., 286:2492-2503. PMID: 21068383, PMCID: PMC3024744. reprint
Reed KA, Tucker DE, Aloulou A, Adler D, Ghomashchi F, Gelb MH, Leslie CC, Oates JA, Boutaud O. (2011) “Functional characterization of mutations in inherited human cPLAâ‚‚ deficiency.” Biochemistry. 50(10):1731-8. PMID: 21247147, PMCID: PMC3051024. reprint
Mouchlis, V.D., Magrioti, V., Barbayianni, E., Cermak, N., Oslund, R.C., Mavromoustakos, T.M., Gelb, M.H., Kokotos, G. (2011) ” Inhibition of secreted phospholipases A2 by 2-oxoamides based on alpha-amino acids: Synthesis, in vitro evaluation and molecular docking calculations.” Bioorg Med Chem. 19(2):735-43. PMID: 21216150, PMCID: PMC3050527. reprint
Lai, Y., Oslund, R. C., Bollinger, J. G., Henderson, W. R. Jr., Santana, L. F., Altemeier, W. A., Gelb, M. H., Hallstrand, T. S. (2010) “Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X,” J. Biol. Chem., 285(53):41491-41500. PMID: 20974857, PMCID: PMC3009875. reprint supp.
Boilard, E., Lai, Y., Larabee, K., Balestrieri, B., Ghomashchi, F., Fujioka, D., Gobezie, R., Coblyn, J. S., Weinblatt, M. E., Massarotti, E. M., Thornhill, T. S., Divangahi, M., Remold, H., Lambeau, G., Gelb, M. H., Arm, J. P., Lee, D. M.(2010) “A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis,” EMBO Mol. Med., 2(5):172-187. PMID: 20432503, PMCID: PMC3058614. reprint
Shridas, P., Bailey, W. M., Boyanovsky, B. B., Oslund, R. C., Gelb, M. H., Webb, N. R. (2010) “Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands,” J. Biol. Chem., 285(26):20031-20039. PMID: 20421306, PMCID: PMC2888415. reprint
Ghomashchi, F., Naika, G. S., Bollinger, J. G., Aloulou, A., Lehr, M., Leslie, C. C., Gelb, M. H. (2010) “Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2{beta}) and comparison with the other cPLA2 isoforms,” J. Biol. Chem., 285(46):36100-36111. PMID: 20705608, PMCID: PMC2975232. reprint supp.
Zack, M., Boyanovsky, B. B., Shridas, P., Bailey, W., Forrest, K., Howatt, D. A., Gelb, M. H., de Beer, F. C., Daugherty, A., Webb, N. R. (2010) “Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice,” Atherosclerosis, 214:58-64. PMID: 20833395, PMCID: PMC3005558. reprint
Bollinger, J. G., Thompson, W., Lai, Y., Oslund, R. C., Hallstrand, T. S., Sadilek, M., Tureček, F., Gelb, M. H. (2010) “Improved sensitivityi mass spectrometric detection of eicosanoids by charge reversal derivatization,” Anal. Chem., 82:6790-6796. PMID: 20704368, PMCID: PMC2959116. reprint supplement
Shridas, P., Bailey, W. M., Gizard, F., Oslund, R. C., Gelb, M. H., Bruemmer, D., Webb, N. R. (2010) “Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages,” Arterioscler Thromb Vasc Biol., 30:2014-2021. PMID: 20844270, PMCID: PMC2958102. reprint supplement
Shridas, P., Bailey, W. M., Boyanovsky, B. B., Oslund, R. C., Gelb, M. H., Webb, N. R. (2010) “Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands,” J. Biol. Chem., 285:20031-20039. PMID: 20421306, PMCID: PMC2888415. reprint
Granata, F., Frattini, A., Loffredo, S., Staiano, R. I., Petraroli, A., Ribatti, D., Oslund, R., Gelb, M. H., Lambeau, G., Marone, G., Triggiani, M. (2010) “Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A(2),” J. Immunol., 184:5232-5241. PMID: 20357262, PMCID: PMC3073479. reprint
Hallstrand, T. S., Wurfel, M. M., Lai, Y., Ni, Z, Gelb, M. H., Altemeier, W. A., Beyer, R. P., Aitken, M. L., Henderson, W. R. (2010) “Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes,” PLoS One, 5(1):e8583. PMID: 20052409, PMCID: PMC2797392. reprint
Surrel, F., Jemel, I., Boilard, E., Bollinger, J. G., Payre, C., Mounier, C. M., Talvinen, K. A., Laine, V. J., Nevalainen, T. J., Gelb, M. H., Lambeau, G. (2009) “Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators,” Mol. Pharmacol., 76:778-790. PMID: 19602573, PMCID: PMC2769042. reprint
Leslie, C. C., Gangelhoff, T. A., Gelb, M. H. (2010) “Localization and function of cytosolic phospholipase A(2)alpha at the Golgi,” Biochimie, 92:620-626. PMID: 20226226, PMCID: PMC2878860. reprint
Olson, E. D., Nelson, J., Griffith, K., Nguyen, T., Streeter, M., Wilson-Ashworth, H. A., Gelb, M. H., Judd, A. M., Bell, J. D. (2010) “Kinetic evaluation of cell membrane hydrolysis during apoptosis by human isoforms of secretory phospholipase A2,” J. Biol. Chem., 285:10993-11002. PMID: 20139082, PMCID: PMC2856304. reprint supplement
Bollinger, J. G., Ii, H., Sadilek, M. and Gelb, M. H., (2010) “Improved method for the quantification of lysophospholipids including enol ether species by liquid chromatography-tandem mass spectrometry,” J. Lipid Res., 51:440-447. PMID: 19717841, PMCID: PMC2803247. reprint supp.
Rosenson, R. S., Gelb, M. H. (2009) “Secretory phospholipase A(2): A multifaceted family of proatherogenic enzymes,” Curr. Cardiol. Rep., 11:445-451. PMID: 19863869. reprint
Regan-Klapisz, E., Krouwer, V., Langelaar-Makkinje, M., Nallan, L., Gelb, M., Gerritsen, H., Verkleij, A. J. and Post, J. A. (2009) “Golgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins”, Molecular Biology of the Cell, 20:4225-4234. PMID: 19675210, PMCID: PMC2754936. reprint
Surrel, F., Jemel, I., Boilard, E., Bollinger, J. G., Payre, C., Mounier, C. M., Talvinen, K. A., Laine, V. J., Nevalainen, T. J., Gelb, M. H., Lambeau, G. (2009) “Group X pospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators,” Mol. Pharmacol., 76:778-790. PMID: 19602573, PMCID: PMC2769042. reprint
Triggiani, M., Giannattasio, G., Calabrese, C., Loffredo, S., Granata, F., Fiorello, A., Santini, M., Gelb, M. H. (2009) “Lung mast cells are a source of secreted phospholipases A2”, J. Allergy Clin Immunol., 124:558-565. PMID 19541351, PMCID: PMC2788562. reprint
Balestrieri, B., Maekawa, A., Xing, W., Gelb, M.H., Katz, H.R., Arm, J.P. (2009) “Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans”, J. Immunol., 182(8):4891-4898. PMID: 19342668, PMCID: PMC2746418. reprint
Giannattasio, G., Lai, Y., Granata, F., Mounier, C.M., Nallan, L., Oslund, R., Leslie, C.C., Marone, G., Lambeau, G., Gelb, M.H., Triggiani, M. (2009) “Expression of phospholipases A(2) in primary human lung macrophages Role of cytosolic phospholipase A(2)-alpha in arachidonic acid release and platelet activating factor synthesis”, Biochim Biophys Acta, 1791(2):92-102. PMID: 19130898, PMCID: PMC2676353. reprint
Tucker, D.E., Ghosh, M., Ghomashchi, F., Loper, R., Suram, S., St. John, B., Girotti, M., Bollinger, J.G., Gelb, M.H., Leslie, C.C. (2009) “Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function, J. Biol. Chem., J. Biol. Chem, 284:9596-9611. PMID: 19176526, PMCID: PMC2666612. reprint supplement
Tucker, D.E., Gijon, M.A., Spencer, D.M., Qiu, Z.H., Gelb, M.H., Leslie, C.C., (2008) “Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages”, J. Leukoc Biol., 84(3):798-806. reprint
Lambeau G., Gelb, M. H. (2008) “Biochmistry and physiology of mammalian secreted phospholipases A2” Annu Rev Biochem, 77:495-520. reprint
Patel, MI, Singh, J, Niknami, M, Kurek, C, Yao, M, Lu, S, Maclean, F, King, NJ, Gelb, MH, Scott, KF, Russell, PJ, Boulas, J, Dong, Q. (2008) “Cytosolic Phospholipase A2-alpha: A potential therapeutic target for prostrate cancer”, Clin Cancer Res., 14:8070-8079. reprint
Su, W, Yeku, O, Olepu, S, Genna, A, Park, J-S, Ren, H, Du, G, Gelb, MH, Morris, AJ, and Frohman, MA (2008) “FIPI, a Phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis,” Molecular Pharmocology Fast Forward, published December 8, 2008, mol.108.053298. reprint
Oslund, RC, Cermak, N, Verlinde, CLM, Gelb, MH, (2008) “Simplified YM-26734 Inhibitors of secreted phospholipase A2 group IIA,” Bioorganic and Medicinal Chemistry Letters, 18:5415-4319. reprint supp.
Wilensky, RL, Shi, Y, Mohler, ER, III, Hamamdzic, D, Burgert, ME, Li, J, Postle, A, Fenning, RS, Bollinger, JG, Hoffman, BE, Pelchovitz, DJ, Yang, J, Mirabile, RC, Webb, CL, Zhang, L, Zhang, P, Gelb, MH, Walker, MC, Zalewski, A, and Macphee, CH, (2008) “Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development,” Nature Medicine, 14 (10):1059-1066. reprint supp.
Oslund, RC, Cermak, N, Gelb, MH, (2008) “Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2,” J. Med. Chem., 51:4708-4714. reprint.pdf supp.
Tribler, L, Jensen, LT, Jørgensen, K, Brünner, N, Gelb, MH, Nielsen, HJ and Jensen, SS, (2007) “Increased expression and activity of group IIA and X secretory phospholipase A2 in Peritumoral versus central colon carcinoma tissue,” Anticancer Research, 27:3179-3186. reprint.pdf
Morgan, D, Cherny, VV, Finnegan A, Bollinger J, Gelb MH, DeCoursey TE. (2007) “Sustained activation of proton cheannels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not CPLA2 alpha activity,” J. Physiol., 579(Pt 2):327-344. reprint.pdf
Hallstrand, TS, Chi, EY, Singer, AG, Gelb, MH, Henderson, Jr., WR (2007) “Secreted phospholipase A2 group X overexpression in asthma and bronchial hyperresponsiveness,” Am. J. Respir Crit Care Med., 176:1072-1078. reprint
Wichmann O, Gelb MH, Schultz, C. (2007) “Probing Phospholipase A2 with fluorescent phospholipid Substrates,” ChemBioChem, 8:1555-1569. reprint.pdf
Ghomashchi, F., Bollinger, J.G. and Gelb, M. H. (2007) “Facile preparation of leukotrienes C4, D4 and E4 containing carbon-13 and nitrogen-15 for quantification of cysteinyl leukotrienes by mass spectrometry,” J. Radiolabel. Compds Radiopharm. 50:729 reprint.pdf
Ghosh, M., Loper, R., Ghomashchi, F., Tucker, D.E., Bonventre, J.V., Gelb, M.H. and Christina C. Leslie. (2007) “Function, Activity, and Membrane Targeting of Cytosolic Phospholipase A2-zeta in Mouse Lung Fibroblasts,” J. Biol. Chem. 282:11676 reprint.pdf
Henderson, W.R., Chi, E.Y., Bollinger, J.G., Tien, Y.T., Ye, X., Castelli, L. Rubtsov, Y.P., Singer, A.G., Chiang, G.K., Nevalainen, T., Rudensky, A.Y. and M. Gelb. (2007) “Importance of Group X-secreted Phospholipase A2 in Allergen-Induced airway inflammation and remodeling in a mouse asthma model,” J. Exp. Med. April 16 204:865-877 reprint.pdf
Rouault M, Calvez CL, Boilard E, Surrel F, Singer A, Ghomashchi F, Bezzine S, Scarzello S, Bollinger J, Gelb MH, Lambeau G. (2007) ” Recombinant production and properties of binding of the full set of mouse secreted phospholipases a(2) to the mouse m-type receptor,” Biochemistry 46:1647-62. reprint.pdf
Boilard, E., Rouault, M., Surrel, F., Le Calvez, C. Bezzine, S., Singer, A., Gelb, M.H. and Gerard Lambeau. (2006) “Secreted Phospholipase A2 Inhibitors Are Also Potent Blockers of Binding to the M-Type Receptor,” Biochemistry 45:13202 reprint.pdf
Karabina, S.A., Brocheriou, I., Le Naour, G., Agrapart, M., Durand, H., Gelb, M.H., Lambeau, G. and Ewa Ninio.(2006) “Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function,” The FASEB Journal 20:E2 [Published online Oct. 31] reprint.pdf
Ghosh, M., Loper, R., Gelb, M.H. and Leslie, C.C.(2006) “Identification of the Expressed Form of Human Cytosolic Phospholipase A2β (cPLA2β),” J. Biol. Chem. 281:16615. reprint.pdf
Gelb, M. H., Mounier, Carine M., Hefner, Ying, Watson, Steve P., Platelet Phospholipases A2. In Platelets in thrombotic and non-thrombotic disorders: pathophysiology, pharmacology, and therapeutics, Gresele, P. e. a., Ed. Cambridge University Press: Cambridge, 2002; pp 221-237. reprint.pdf
Ni,Z., Okeley, N. M., Smart, B.P., and Michael H. Gelb (2006)” Intracellular Actions of Group IIA Secreted Phospholipase A2 and Group IVA Cytosolic Phospholipase A2 Contribute to Arachidonic Acid Release and Prostaglandin Production in Rat Gastric Mucosal Cells and Transfected Human Embryonic Kidney Cells” J. Biol. Chem., 281: 16245-55 . reprint.pdf
Eerola, L.I., Surrel, F., Nevalainen, T.J., Gelb, M.H., Lambeau, G. and V. Jukka O. Laine (2006) “Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels,” Biochimica et Biophysica Acta [Epub ahead of print] April 10 reprint.pdf
Rouault, M., Rash, L. D., Escoubas, P., Boilard, E., Bollinger,J., Lomonte,B., Maurin, T., Guillaume,C., Canaan, S., Deregnaucourt, C., Schrevel,J., Doglio, A., Gutierrez, J. M., Lazdunski, M., Gelb, M. H., and G. Lambeau. (2006) “Neurotoxicity and Other Pharmacological Activities of the Snake Venom
Phospholipase A2 OS2: The N-Terminal Region Is More Important Than Enzymatic
Activity,” Biochemistry [Epub ahead of print] Feb. 14 reprint.pdf
Smart, B.P., Oslund, R.C. and Walsh, L.A. (2006) ” The First Potent Inhibitor of Mammalian Group
X Secreted Phospholipase A2: Elucidation of Sites for Enhanced Binding,” J. Med. Chem. Feb. 8 ; [Epub ahead of print] reprint.pdf supplement
Huhtinen, H.T., Gronroos, J.O., Gronroos, J.M. Uksila, J., Gelb, M.H., Nevalainen, T.J. and Laine, V.J. (2006) “Antibacterial effects of human group IIA and group XIIA phospholipase A2 against Helicobacter pylori in vitro,” APMIS 114:127-30 reprint.pdf
Vandal, O.H., Gelb, M.H., Ehrt, S. and Nathan, C.F. (2006) “Cytosolic Phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in Vitro ,” Infect. Immun. Mar. 74:1751-6. reprint.pdf
Nevalainen, T.J., Eerola, L.I., Rintala, E., Laine, V.J., Lambeau, G. and Gelb, M.H. (2005) ” Time-resolved fluoroimmunoassays of the complete set of secreted phospholipases A2 in human serum,” Biochim Biophys Acta. 1733:210-213 reprint.pdf
Forsell, P.K., Olsson, A.O., Andersson, E., Nallan, L. and Gelb, M.H. (2005) “Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A(2)-alpha,” Biochem Pharmacol. Nov. 12 ; [Epub ahead of print] reprint.pdf
Petan, T., Krizaj, I., Gelb, MH. and Pungercar, J. (2005) “Ammodytoxins, potent presynaptic neurotoxins, are also highly efficient phospholipase A(2) enzymes,” Biochemistry, 44:12535-12545 reprint.pdf
Tucker, D.E., Stewart, A., Nallan, L., Bendale, P., Ghomashchi, F., Gelb, MH. and Leslie, CC. (2005)
“Group IVC cytosolic phospholipase A2
is farnesylated and palmitoylated in mammalian cells,”
J. Lipid Res., 46:2122-33. reprint.pdf
Kita, Y., Takahashi, T., Uozumi, N., Nallan, L.,Gelb, M.H. and Shimizu, T. (2005) “Pathway-oriented profiling of lipid mediators in macrophages,” Biochem. Biophys. Res. Commun., 330:898-906. reprint.pdf
Nielsen, R.D., Che, K., Gelb, M.H. and Robinson, B.H. (2005) “A Ruler for Determining the Position of Proteins in Membranes,” J. Am. Chem. Soc., 127:6430-42. reprint.pdf data supplement.pdf
Babon, A., Almunia, C., Boccaccio, C., Beaumelle, B., Gelb, M.H., Menez, A., Maillere, B., Abastado, J.P., Salcedo, M. and Gillet, D., (2005) “Cross-presentation of a CMV pp65 epitope by human dendritic cells using bee venom PLA(2) as a membrane-binding vector,” FEBS Lett., 579:1658-64. reprint.pdf
Yuan, C., Tu, S., Gelb, M.H. and Tsai, M-D. (2005) “Unusual Four-Bond Secondary H/D Isotope Effect Supports a Short-Strong Hydrogen Bond between Phospholipase A2 and a Transition State Analogue Inhibitor,” Biochemistry, 44:4748-54. reprint.pdf
Granata, F., Petraroli, A., Boilard, E., Bezzine, S., Bollinger, J., Del Vecchio, L., Gelb, M.H., Lambeau, G., Marone, G., and Triggiani M. (2005) “Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the m-type receptor,” J. Immunol., 174: 464-74. reprint.pdf
Masuda, S., Murakami, M., Matsumoto, S., Eguchi, N., Urade, Y., Lambeau, G., Gelb, M.H., Ishikawa, Y., Ishii, T. and Kudo, I. (2004) “Localization of various secretory phospholipase A(2) enzymes in male reproductive organs,” Biochim Biophys Acta., 1686:61-76. reprint.pdf
Ivanovski, G., Petan, T., Krizaj, I., Gelb, M.H., Gubensek, F. and Pungercar, J. (2004) “Basic amino acid residues in the beta-structure region contribute, but not critically, to presynaptic neurotoxicity of ammodytoxin A,” Biochim Biophys Acta., 1702:217-25. reprint.pdf
Buhot, C., Chenal, A., Sanson, A., Pouvelle-Moratille, S., Gelb, M.H., Menez, A., Gillet, D. and Maillere, B. (2004) “Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity,” Protein Sci. 13:2970-8. reprint.pdf
Smart, B.P., Pan, Y.H., Weeks, A.K., Bollinger, J.G., Bahnson, B.J. and Gelb, M.H. (2004) “Inhibition of the complete set of mammalian secreted phospholipases A(2) by indole analogues a structure-guided study,” Bioorg Med Chem., 12:1737-49. reprint.pdf
Landreville, S., Coulombe, S., Carrier, P., Gelb, M.H., Guérin, S.L., and Salesse, C. (2004) Expression of Phospholipases A2 and C in Human Corneal Epitheliel Cells,” IOVS, 45:3997-4003. reprint.pdf
Bollinger, J.G., Diraviyam, K., Ghomashchi, F., Murray, D., and Gelb, M.H. (2004) “Interfacial Binding of Bee Venom Secreted Phospholipase A2 to Membranes Occurs Predominantly by a Nonelectrostatic Mechanism,” Biochemistry, 43:13293-13304. reprint.pdf
Rubin, B.B., Downey, G.P., Koh, A., Degousee, N., Ghomashchi, F., Nallan, L., Stefanski, E., Smart, B.P., Lindsay, T.F., Cherepanov, V., Vachon, E., Kelvin, D., Sadilek, M., Brown, G.E., Yaffe, M.B., Plumb, J., Grinstein, S., Glogauer, M., and Gelb, M.H. (2004) “Cytosolic phospholipase A2 alpha is necessary for platelet activating factor biosynthesis, efficient neutrophil mediated bacterial killing and the innate immune response to pulmonary infection,” J. Biol. Chem., 280:7519-29. reprint.pdf
Haas, U., Podda, M., Behne, M., Gurrieri, S., Alonso, A., Fürstenberger, G., Pfeilschifter, J., Lambeau, G., Gelb, M.H., and Kaszkin, M. (2004) “Characterization and Differentiation-dependent Regulation of Secreted Phospholipases A2 in Human Keratinocytes and in Healthy and Psoriatic Human Skin,” J. Invest. Dermatol., 124:204-211. reprint.pdf
Sved, P., Scott, K.F., McLeod, D., King, N.J., Singh, J., Tsatralis, T., Nikolov, B., Boulas, J., Nallan, L., Gelb, M.H., Sajinovic, M., Graham, G.G., Russell, P.J., and Dong, Q. (2004) “Oncogenic action of secreted phospholipase A2 in prostate cancer,” Cancer Res., 64: 6934-40. reprint.pdf
Nielsen, R.D., Canaan, S., Gladden, J.A., Gelb, M.H., Mailer, C., and Robinson, B.H. (2004) “Comparing continuous wave progressive saturation EPR and time domain saturation recovery EPR over the entire motional range of nitroxide spin labels,” J Magn Reson., 169:129-63. reprint.pdf
Leslie, C.C., Gelb, M.H. (2004) “Assaying phospholipase A2 activity,” Methods Mol Biol., 284:229-42. reprint.pdf
Mounier, C.M., Ghomashchi, F., Lindsay, M.R., James, S., Singer, A.G., Parton, R.G., and Gelb, M.H. (2004) “Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A2 occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A2-a,” J. Biol. Chem. 279:25024-25038. reprint.pdf, supplement
Okeley, N.M, Gelb, M.H. (2004) “Membrane Transport, Structure, Function, and Biogenesis: A designed probe for acidic phospholipids reveals the enriched anionic character of the cytosolic face of the mammalian plasma membrane,” J. Biol. Chem, 279:21833-21840. reprint.pdf
Stephane Canaan, S., Zoltan Zadori, Z., Ghomashchi,F., Bollinger, J., Sadilek, M., Marie Eve Moreau, M.E., Tijssen, P., and Gelb, M.H. (2004) “Interfacial enzymology of parvovirus phospholipases A2,” J. Biol. Chem, 279:14502-14508. reprint.pdf
Triggiani, M., Giannattasio, G., Balestrieri, B., Granata, F., Gelb, M.H., de Paulis, A., and Marone, G. (2004) “Differential modulation of mediator release from human basophils and mast cells by mizolastine,” Clin. Exp. Allergy, 34:241-9. reprint.pdf
Rounault, M., Bollinger, J.G., Lazdunski, M., Gelb, M.H., Lambeau, G. (2003) “Novel Mammalian Group XII Secreted Phospholipase A2 Lacking Enzymatic Activity,” Biochemistry, 42:11494-11503. reprint.pdf
Beck, S., Lambeau, G., Scholz-Pedretti, K., Gelb, M.H., Janssen, M.J.W., Edwards, S.H., Wilton, D.C., Pfeilschifter, J., and Kaszkin, M. (2003) “Potentiation of TNFa-induced sPLA2-IIA expression in mesangial cells by an autocrine loop involving secreted phospholipase A2 and PPARa activation,” J. Biol. Chem., 278:29799-29812. reprint.pdf
Gurrieri, S., Fürstenberger, G., Schadow, A., Haas, U., Singer, A.G., Ghomashchi, F., Pfeilschifter, J., Lambeau, G., Gelb, M.H., and Kaszkin, M. (2003) “Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis,” J. Invest. Dermatol., 121:156-164. reprint.pdf
Poi, M.J., Tomaszewski, J.W., Yuan, C., Dunlap, C.A., Andersen, N.H., Gelb, M.H., and Tsai, M.-D. (2003) “A low-barrier hydrogen bond between histidine of secreted phospholipase A2 and a transition state analog inhibitor,” J. Mol. Biol., 329:997-1009. reprint.pdf
Beers, S.A., Buckland, A.G., Giles, N., Gelb, M.H. and Wilton, D.C. (2003) “Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2,” Biochem., 42(24):7326-7338. reprint.pdf
Murakami, M., Masuda, S., Shimbara, S., Bezzine, S., Lazdunski, M., Lambeau, G., Gelb, M.H., Matsukura, S., Kokubu, F., Adachi, M. and Kudo, I. (2003) “Cellular Arachidonate-Releasing Function of Novel Classes of Secretory Phospholipase A2s (Group III and XII),” J. Biol. Chem., 278:10657-10667. reprint.pdf
Singer, A.G., Ghomashchi, F., Le Calvez, C., Bollinger, J., Bezzine, S., Rouault, M., Sadilek, M., Lazdunski, M., Lambeau, G., and Gelb, M.H. (2002) “Interfacial Kinetic and Binding Properties of the Complete set of Human and Mouse Groups I, II, V, X, and XII Secreted Phospholipases A2,” J. Biol. Chem., 277:48535-48549. reprint.pdf
Bezzine, S., Bollinger, J.G., Singer, A.G., Veatch, S.L., Keller, S.L., and Gelb, M.H. (2002) “On the Binding Preference of Human Groups IIA and X Phospholipases A2 for Membranes with Anionic Phospholipids,” J. Biol. Chem., 277:48523-48534. reprint.pdf
Koprivnjak, T., Peschel, A., Gelb, M.H., Liang, N.S., and Weiss, J.O. (2002) “Role of charge properties of bacterial envelope in bactericidal action of human Group IIA phospholipase A2 against Staphylococcus andreas,” J. Biol. Chem., 277:47636-47644. reprint.pdf
Murakami, M., Yoshihara, K., Shimbara, S., Lambeau, G., Gelb, M.H., Singer, A.G., Sawada, M., Inagaki, N., Nagai, H., Ishihara, M., Ishikawa, Y., Ishii, T., and Kudo, I. (2002) “Cellular Arachidonate-releasing Function and Inflammation-associated Expression of Group IIF Secretory Phospholipase A2,” J. Biol. Chem., 277(21):19145-19155. reprint.pdf
Pan, Y.H., Yu, B.-Z., Singer, A.G., Ghomashchi, F., Lambeau, G., Gelb, M.H., Jain, M.J., and Bahnson, B.J. (2002) “Crystal structure of human group-X secreted phospholipase A2; electrostatically neutral interfacial binding surface targets zwitterionic membranes,” J. Biol. Chem., 277:29086-29093. reprint.pdf
Canaan, S., Nielsen, R., Ghomashchi, F., Robinson, B.H., and Gelb, M.H. (2002) “Unusal Mode of Binding of human group-IIA secreted phospholipase A2 to anionic interfaces as studied by continuous wave and time domain electron paramagnetic resonance spectroscopy,” J. Biol. Chem, 277:30984-30990. reprint.pdf
Murakami, M., Yoshihara, K., Shimbara, S., Lambeau, G., Singer, A., Gelb, M.H., Sawada, M., Inagaki, N., Nagai, H., and Kudo, I. (2002) “Arachidonate release and eicosanoid generation by group IIE phospholipase A2,” Biochem. Biophys. Res. Comm., 292(3):689-696. reprint.pdf
Degousee, N., Ghomashchi, F., Stefanski, E., Singer, A., Smart, B.P., Borregaard, N., Reithmeier, R., Lindsay, T.F., Lichtenberger, C., Reinisch, W., Lambeau, G., Arm, J., Tischfield, J.T., Gelb, M.H., and Rubin, B.B. (2001) “Groups IV, V and X Phospholipases A2 in Human Neutrophils,” J. Biol. Chem., 277(7):5061-5073. reprint.pdf
Beers, S.A., Buckland, A.G., Koduri, R.S., Cho, W., Gelb, M.H., and Wilton, D.C. (2002) “The antibacterial properties of secreted phospholipases A2: a major physiological role for the group IIA enzyme that depends on the very high pI of the enzyme to allow penetration of the bacterial cell wall,” J. Biol. Chem., 277(3):1788-1793. reprint.pdf
Koduri, R.S., Grönroos, J.O., Laine, V.J.O., Calvez, C.L., Lambeau, G., Nevalainen, T.J., and Gelb, M.H. (2002) “Bactericidal Properties of Human and Murine Groups I, II, V, X, and XII Secreted Phospholipases A2,” J. Biol. Chem., 277:5849-5857. reprint.pdf
Berg, O.G., Gelb, M.H., Tsai, M.-D., and Jain, M.K. (2001) “Interfacial Enzymology: The Secreted Phospholipase A2-Paradigm,” Chem. Rev., 101:2613-2653. reprint.pdf
Muthalif, M.M., Hefner, Y., Canaan, S., Harper, J., Zhou, H., Parmentier, J.-H., Aebersold, R., Gelb, M.H., and Malik, K.U. (2001) “Functional Interacton of Calcium/Calmodulin-Dependent Protein Kinase II and Cytosolic Phospholipase A2.” J. Biol. Chem., 276: 39653-39660. reprint.pdf
Ghomaschi, F., Stewart, A., Hefner, Y., Ramanadham, S., Turk, J., Leslie, C.C., and Gelb, M.H. (2001) “A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2[alpha] blocks arachidonic acid release in a variety of mammalian cells.” Biochimica et Biophysica Acta. 78118:1-7. reprint.pdf
Min, J.H., Wilder, C., Aoki, J., Arai, H., Inoue, K., Paul, L., and Gelb, M.H. (2001) “Platelet-Activating Factor Acetylhydrolases: Broad Substrate Specificity and Lipoprotein Binding Does Not Modulate the Catalytic Properties of the Plasma Enzyme.” Biochemistry. 40(15):4539-4549. reprint.pdf
Schadow, A., Scholz-Pedretti, K., Lambeau, G., Gelb, M.H., Furstenberger, G., Pfeilschifter, J., and Kaszkin, M. (2001) “Characterization of group X phospholipase A2 as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA,” J. Investig. Dermatol., 116(1):31-39. reprint.pdf
Valentin E, Singer AG, Ghomashchi F, Lazdunski M, Gelb MH, Lambeau G. Cloning and Recombinant Expression of Human Group IIF-Secreted Phospholipase A(2). Biochem Biophys Res Commun. 279:223-228. reprint.pdf
Mounier CM, Luchetta P, Lecut C, Koduri RS, Faure G, Lambeau G, Valentin E, Singer A, Ghomashchi F, Beguin S, Gelb MH, Bon C. Related Articles, Links Basic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2. Eur J Biochem. 2000 Aug;267(16):4960-4969. reprint.pdf
M. Murakami, R. S. Koduri, A. Enomoto, S. Shimbara, M. Seki, K. Yoshihara, A. Singer, E. Valentin, F. Ghomashchi, G. Lambeau, M.H. Gelb, and I. Kudo (2000) Distinct Arachidonate-Releasing Functions of Mammalian Secreted Phospholipase A2s in Human Embryonic Kidney 293 and Rat Mastocytoma RBL-2H3 Cells through Heparin Sulfate Shuttling and External Plasma Membrane Mechanisms, J. Biol. Chem., 276(13):10083-10096. reprint.pdf
Ying Hefner, Angelika G. Borsch-Haubold, Makomoto Murakami, Jonathan I. Wilde, Sophie Pasquet, David Schieltz, Farideh Ghomashchi, John R. Yates, III,Christopher G. Armstrong, Andrew Paterson, Philip Cohen, Rikiro Fukunaga, Tony Hunter, Ichiro Kudo, Steve P. Watson, and Michael H. Gelb. Serine-727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases J. Biol. Chem., 275:37543-37551 reprint.pdf
Enomoto A., Murakami, M., Valentin, E., Lambeau, G. Gelb, M. H. and Kudo, I; Redundant and Segregated Functions of Granule-Associated Heparin-Binding Group II Subfamily of Secretory Phospholipases A2 in the Regulation of Degranulation and Prostaglandin D2 Synthesis in Mast Cells: J. Immunol. 4007-4014 (2000). reprint.pdf
Gelb MH, Min J, Jain MK. (2000) Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes. Biochim Biophys Acta. 2000 Oct 31; 1488(1-2):20-27. reprint.pdf
Linda S. Jung, Jennifer S. Shumaker-Parry, Charles T. Campbell,* Sinclair S. Yee, and Michael H. Gelb* ; Quantification of Tight Binding to Surface-Immobilized Phospholipid Vesicles Using Surface Plasmon Resonance: Binding Constant of Phospholipase A2, Journal of the American Chemical Society; 2000; 122(17); 4177-4184. reprint.pdf
Gelb MH, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G. Cloning and recombinant expression of a structurally novel human secreted phospholipase A2. J Biol Chem. 2000; 275(51); 39823-39826. reprint.pdf
Bezzine S, Koduri RS, Valentin E, Murakami M, Kudo I, Ghomashchi F, Sadilek M, Lambeau G, Gelb MH. Exogenously added human group X secreted phospholipase A(2) but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells. Journal of Biological Chemistry. 275(5): 3179-91, Feb 2000 reprint.pdf
Valentin E, Ghomashchi F, Gelb MH, Lazdunski M, Lambeau G. Novel secreted phospholipase A(2) with homology to the group III bee venom enzyme. Journal of Biological Chemistry. 275, 7492-7496, 2000 reprint.pdf
Valentin E, Ghomashchi F, Gelb MH, Lazdunski M, Lambeau G. On the diversity of secreted phospholipases A(2). Cloning,tissue distribution, and functional expression of two novel mouse group II enzymes. Journal of Biological Chemistry. 274(44):31195-202, Oct 1999 reprint.pdf
F. Ghomashchi, R. Loo, J. Balsinde, F. Bartoli, E. A. Dennis, and M. H. Gelb (1999) Trifluoromethyl ketones and methyl fluorophosphonates as inhibitors of group IV and VI Phospholipases A2: structure-function studies with vesicle, micelle and membrane assays. Biochim. Biophys. Acta 1420, 45-56. reprint.pdf
Min JH, Jain MK, Wilder C, Paul L, Apitz-Castro R, Aspleaf DC, Gelb MH. Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase. Biochemistry. 38(39): 12935-42, Sep 1999. reprint.pdf
Buschbeck M, Ghomashchi F, Gelb MH, Watson SP, Borsch-Haubold AG. Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A2. Biochemical Journal. 344 Pt 2: 359-66, Dec 1999. reprint.pdf
Valentin E, Koduri RS, Scimeca JC, Carle G, Gelb MH, Lazdunski M, Lambeau G. Cloning and recombinant expression of a novel mouse-secreted phospholipase A2. J Biol Chem. 1999 Jul 2;274(27):19152-60. reprint.pdf
Gelb, MH, Cho, W, and Wilton, DC. (1999) “Interfacial binding of secreted phospholipases A2: more than electrostatics and a major role for tryptophan,” Curr. Opinion in Struct. Biol., 9(4):428-432. reprint.pdf
Han SK, Kim KP, Koduri R, Bittova L, Munoz NM, Leff AR, Wilton DC, Gelb MH, Cho W. Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2. J Biol Chem 274(17): 11881-8, Apr 1999. reprint.pdf
Ball A; Nielsen R; Gelb MH; Robinson BH. Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance.. Proc Natl Acad Sci U S A. 96(12): 6637-42, 8 Jun 1999. reprint.pdf
Hixon MS, Ball A, Gelb MH. Calcium-dependent and -independent interfacial binding and catalysis of cytosolic group IV phospholipase A2. Biochemistry. 1998 Jun 9;37(23):8516-26. reprint.pdf
Ghomashchi F;Lin Y;Hixon M S;Yu B Z;Annand R;Jain M K;Gelb M H. Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis.. Biochemistry. 37(19): 6697-710, 12 May 1998. reprint.pdf
Lin Y; Nielsen R;Murray D;Hubbell W L;Mailer C;Robinson B H;Gelb M H. Docking phospholipase A2 on membranes using electrostatic potential-modulated spin relaxation magnetic resonance. Science. 279(5358): 1925-9, 20 Mar 1998 reprint.pdf
Koduri RS, Baker SF, Snitko Y, Han SK, Cho W, Wilton DC, Gelb MH. Action of human group IIa secreted phospholipase A2 on cell membranes. Vesicle but not heparinoid binding determines rate of fatty acid release by exogenously added enzyme. J Biol Chem. 273(48): 32142-53, Nov 1998. reprint.pdf
Borsch-Haubold AG, Bartoli F, Asselin J, Dudler T, Kramer RM, Apitz-Castro R, Watson SP, Gelb MH. Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. J Biol Chem. 1998 Feb 20;273(8):4449-58. reprint.pdf
Nicolas JP, Lin Y, Lambeau G, Ghomashchi F, Lazdunski M, Gelb MH. Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity. J Biol Chem. 1997 Mar 14;272(11):7173-81.reprint.pdf
Snitko Y, Koduri RS, Han SK, Othman R, Baker SF, Molini BJ, Wilton DC, Gelb MH, Cho W. Mapping the interfacial binding surface of human secretory group IIa phospholipase A2. Biochemistry. 1997 Nov 25;36(47):14325-33.reprint.pdf
Yu B Z;Ghomashchi F;Cajal Y;Annand R R;Berg O G;Gelb M H;Jain M K. Use of an imperfect neutral diluent and outer vesicle layer scooting mode hydrolysis to analyze the interfacial kinetics, inhibition, and substrate preferences of bee venom phospholipase A2. Biochemistry. 36(13): 3870-81, 1 Apr 1997. reprint.pdf
Annand RR, Kontoyianni M, Penzotti JE, Dudler T, Lybrand TP, Gelb MH. Active site of bee venom phospholipase A2: the role of histidine-34, aspartate-64 and tyrosine-87. Biochemistry. 1996 Apr 9;35(14):4591-601. reprint.pdf
de Carvalho MG, McCormack AL, Olson E, Ghomashchi F, Gelb MH, Yates JR 3rd, Leslie CC. Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes. J Biol Chem. 1996 Mar 22;271(12):6987-97. reprint.pdf
Bayburt T;Gelb M H. Interfacial catalysis by human 85 kDa cytosolic phospholipase A2 on anionic vesicles in the scooting mode. Biochemistry. 36(11): 3216-31, 18 Mar 1997. reprint.pdf