Regnier Lab and Collaborators to Present at the 2020 Biophysical Society Meeting

We are excited about the upcoming Biophysical Society meeting in San Diego, February 15-19.  This year we will have a strong showing of our current mechanistic and translational research, with 10 presentations from our lab and with collaborators.  Here is a list of the scheduled presentations, with the presenter’s name in bold.   If you plan to attend the meeting, please stop by to check them out and give us your feedback.

Sunday, February 16, 2020

Platform: Excitation-Contraction Coupling, 4:00 pm – 6:00 pm, Room 31ABC

169-Plat 5:45 pm

THE E258K-MYPBC3 MODELLED IN HCM PATIENT-DERIVED CARDIOMYOCYTES TO IDENTIFY THE PRIMARY IMPACT OF THE MUTATION VERSUS THE SECONDARY CHANGES DUE TO CARDIAC REMODELING. J. M. Pioner, Sonette Steczina, Giulia Vitale, Saffie Mohran, Chiara Palandri, Lorenzo Santini, Silvia Querceto, Marianna Langione, Elisabetta Cerbai, Chiara Tesi, Raffaele Coppini, Cecilia Ferrantini, Corrado Poggesi, Michael Regnier

Monday, February 17, 2020

Muscle Regulation

1276-Pos Board B344

EXPLORING THE EFFECTS OF 2.DEOXY-ATP ON SERCA 2A USING MULTISCALE MODELING. Kimberly J. McCabe, Sophia P. Hirakis, Abigail E. Teitgen, Alexandre B. Duclos, Michael Regnier, Rommie E. Amaro, Andrew D. McCulloch

Skeletal Muscle Mechanics, Structure, and Regulation

1358-Pos Board B426

DEVELOPMENT OF MECHANICAL AND STRUCTURAL DYSFUNCTION IN SKELETAL MUSCLE FROM A DUCHENE MUSCULAR DYSTROPHY RAT MODEL. Saffie Mohran, Chen-Ching Yuan, Shawn M. Luttrell, Weikang Ma, Thomas C. Irving, David L. Mack, Michael Regnier

1362-Pos Board B430

USE OF CELLS FROM REMOTELY COLLECTED URINE TO GENERATE HUMAN INDUCED PLURIPOTENT STEM CELLS AND MYOFIBERS THAT RECAPITULATE UNCONVENTIONAL MYOPATHIES. Shawn M. Luttrell, Saffie Mohran, Kati Buckingham, Michael J. Bamshad, Michael Regnier, David L. Mack

Tuesday, February 18, 2020

Platform: Cardiac Muscle Regulation, 8:15 am – 10:15 am, Room 30ABC

1600-Plat 9:00 am

TWO SMALL MOLECULE INHIBITORS OF MYOSIN DECREASE FORCE AND INCREASE RATES OF RELAXATION IN DEMEMBRANATED RAT LEFT VENTRICULAR TISSUE. Kristina B. Kooiker, Qing-Fen Gan, Ming Yu, Yuanhua Cheng, Na Sa, Min Zhong, Tim McMillen, Farid Moussavi-Harami, Michael Regnier

Cardiac Muscle Mechanics and Structure

2072-Pos Board B342

CROSS-SPECIES DYNAMICS OF MYOSIN IN PRE-POWERSTROKE STATES. Matthew C. Childers, Valerie Daggett, Michael Regnier

2073-Pos Board B343

EFFECT OF MYOSIN ISOFORM ON MECHANICS IN INTACT CARDIAC TRABECULAE FROM MICE, RATS AND HUMANS. Srboljub M. Mijailovich, Momcilo Prodanovic, Corrado Poggesi, Michael Regnier, Michael A. Geeves

2085-Pos Board B355

NUCLEOTIDE-DEPENDENT ALLOSTERIC COMMUNICATION IN MYOSIN. Matthew C. Childers, Valerie Daggett, Michael Regnier

2091-Pos Board B361

HIPSCS DERIVED CARDIOMYOCYTES OVEREXPRESSING DEOXY ATP TO RESTORE CARDIAC FUNCTION. Ketaki N. Mhatre, Julie Mathieu, Charles E. Murry, Michael Regnier

Wednesday, February 19, 2020

Cardiac Muscle Regulation

2903-Pos Board B449

TWO MYOFILAMENT-BASED APPROACHES TO PREVENT GENETIC DILATED CARDIOMYOPATHY. Claire E. Branley, Farid Moussavi-Harami, Kristina B. Kooiker, Michael Regnier, Jil C. Tardiff, Joelle Tudor, Jeremy Freeman