I am excited to announce that we have been awarded a 5-year, multi-institutional grant from NIH National Institute of General Medicine. The goal of the project is understand how single amino acid mutations in the motor protein myosin leads to changes in muscle function and structure at increasing scales – from proteins to organelles to cells and tissue.  Our lab will collaborate with the lab of David Mack (UW Department of Rehabilitation Medicine) and investigators from Stanford, UC Santa Barbara and the Murie Curie Institute of Paris using human inducible pluripotent stem cells (hiPSCs) differentiated into heart and skeletal muscle cells and a combination of gene editing, biophysics and computational approaches.

To learn more, check out the press release.