Publications | Heart and Muscle Mechanics Lab

Childers MC, Geeves MA, Regnier M. Interacting myosin head dynamics and their modification by 2′-deoxy-ADP. Biophys J. 2024 Nov 19;123(22):3997-4008. doi: 10.1016/j.bpj.2024.10.013. Epub 2024 Oct 22. PubMed PMID: 39444161; PubMed Central PMCID: PMC11617627.

Karbassi E, Yoo D, Martinson AM, Yang X, Reinecke H, Regnier M, Murry CE. Noncontractile Stem Cell-Cardiomyocytes Preserve Post-Infarction Heart Function. Circ Res. 2024 Oct 11;135(9):967-969. doi: 10.1161/CIRCRESAHA.124.325133. Epub 2024 Sep 19. PubMed PMID: 39297201; PubMed Central PMCID: PMC11465756.

Kooiker K, Gan QF, Yu M, Sa N, Mohran S, Cheng Y, Flint G, Neys S, Gao C, Nissen D, McMillen T, Asencio A, Ma W, Irving TC, Moussavi-Harami F, Regnier M. Mechanisms of a novel regulatory light chain-dependent cardiac myosin inhibitor. J Gen Physiol. 2024 Oct 7;156(10). doi: 10.1085/jgp.202313503. Epub 2024 Jul 31. PubMed PMID: 39083045; PubMed Central PMCID: PMC11291911.

Turner KL, Vander Top BJ, Kooiker KB, Mohran S, Mandrycky C, McMillen T, Regnier M, Irving TC, Ma W, Tanner BCW. The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca(2+)]. J Physiol. 2024 Oct;602(19):4941-4958. doi: 10.1113/JP286802. Epub 2024 Sep 16. PubMed PMID: 39283968; PubMed Central PMCID: PMC11466700.

Childers MC, Regnier M. Dynamics of the Pre-Powerstroke Myosin Lever Arm and the Effects of Omecamtiv Mecarbil. Int J Mol Sci. 2024 Sep 27;25(19). doi: 10.3390/ijms251910425. PubMed PMID: 39408754; PubMed Central PMCID: PMC11477208.

Teitgen AE, Hock MT, McCabe KJ, Childers MC, Huber GA, Marzban B, Beard DA, McCammon JA, Regnier M, McCulloch AD. Multiscale modeling shows how 2′-deoxy-ATP rescues ventricular function in heart failure. Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2322077121. doi: 10.1073/pnas.2322077121. Epub 2024 Aug 22. PubMed PMID: 39172779; PubMed Central PMCID: PMC11363293.

Tasfaout H, Halbert CL, McMillen TS, Allen JM, Reyes TR, Flint GV, Grimm D, Hauschka SD, Regnier M, Chamberlain JS. Split intein-mediated protein trans-splicing to express large dystrophins. Nature. 2024 Aug;632(8023):192-200. doi: 10.1038/s41586-024-07710-8. Epub 2024 Jul 17. PubMed PMID: 39020181; PubMed Central PMCID: PMC11335042.

Moussavi-Harami F, Regnier M. Aficamten reduces cardiac contractility by modifying the actomyosin interaction. Nat Cardiovasc Res. 2024 Aug;3(8):893-894. doi: 10.1038/s44161-024-00503-2. PubMed PMID: 39196033.

Nagle A, Regnier M, Davis J. Keeping it fresh: ribosomal protein SA sustains sarcomeric function via localized translation. J Clin Invest. 2024 Jul 1;134(13). doi: 10.1172/JCI181996. PubMed PMID: 38949021; PubMed Central PMCID: PMC11213463.

Bailey LRJ, Bugg D, Reichardt IM, Ortaç CD, Nagle A, Gunaje J, Martinson A, Johnson R, MacCoss MJ, Sakamoto T, Kelly DP, Regnier M, Davis J. MBNL1 Regulates Programmed Postnatal Switching Between Regenerative and Differentiated Cardiac States. Circulation. 2024 Jun 4;149(23):1812-1829. doi: 10.1161/CIRCULATIONAHA.123.066860. Epub 2024 Mar 1. PubMed PMID: 38426339; PubMed Central PMCID: PMC11147738.

Steczina S, Mohran S, Bailey LRJ, McMillen TS, Kooiker KB, Wood NB, Davis J, Previs MJ, Olivotto I, Pioner JM, Geeves MA, Poggesi C, Regnier M. MYBPC3-c.772G>A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2024 Jun;191:27-39. doi: 10.1016/j.yjmcc.2024.04.010. Epub 2024 Apr 20. PubMed PMID: 38648963; PubMed Central PMCID: PMC11116032.

Lee S, Vander Roest AS, Blair CA, Kao K, Bremner SB, Childers MC, Pathak D, Heinrich P, Lee D, Chirikian O, Mohran SE, Roberts B, Smith JE, Jahng JW, Paik DT, Wu JC, Gunawardane RN, Ruppel KM, Mack DL, Pruitt BL, Regnier M, Wu SM, Spudich JA, Bernstein D. Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2318413121. doi: 10.1073/pnas.2318413121. Epub 2024 Apr 29. PubMed PMID: 38683993; PubMed Central PMCID: PMC11087781.

Rynkiewicz MJ, Childers MC, Karpicheva OE, Regnier M, Geeves MA, Lehman W. Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin. J Gen Physiol. 2024 May 6;156(5). doi: 10.1085/jgp.202413538. Epub 2024 Apr 12. PubMed PMID: 38607351; PubMed Central PMCID: PMC11010328.

Wait SJ, Expòsit M, Lin S, Rappleye M, Lee JD, Colby SA, Torp L, Asencio A, Smith A, Regnier M, Moussavi-Harami F, Baker D, Kim CK, Berndt A. Machine learning-guided engineering of genetically encoded fluorescent calcium indicators. Nat Comput Sci. 2024 Mar;4(3):224-236. doi: 10.1038/s43588-024-00611-w. Epub 2024 Mar 21. PubMed PMID: 38532137.

Mollica MY, Olszewski E, Kiyohara CL, Matusalem DD, Ochs AR, Imoukhuede PI, Regnier M, Yasuhara K, Thomas WE, Taylor AC. Incorporating Diversity, Equity, and Inclusion Content Into Bioengineering Curricula: A Program-Level Approach. J Biomech Eng. 2024 Mar 1;146(5). doi: 10.1115/1.4063819. PubMed PMID: 37851545; PubMed Central PMCID: PMC11003107.

Lee JD, Nguyen A, Jin ZR, Moghadasi A, Gibbs CE, Wait SJ, Evitts KM, Asencio A, Bremner SB, Zuniga S, Chavan V, Williams A, Smith N, Regnier M, Young JE, Mack D, Nance E, Boyle PM, Berndt A. Far-red and sensitive sensor for monitoring real time H(2)O(2) dynamics with subcellular resolution and in multi-parametric imaging applications. bioRxiv. 2024 Feb 8;. doi: 10.1101/2024.02.06.579232. PubMed PMID: 38370715; PubMed Central PMCID: PMC10871219.

Mohran S, Kooiker K, Mahoney-Schaefer M, Mandrycky C, Kao K, Tu AY, Freeman J, Moussavi-Harami F, Geeves M, Regnier M. The biochemically defined super relaxed state of myosin-A paradox. J Biol Chem. 2024 Jan;300(1):105565. doi: 10.1016/j.jbc.2023.105565. Epub 2023 Dec 14. PubMed PMID: 38103642; PubMed Central PMCID: PMC10819765.

Mohran S, Steczina S, Mandrycky C, Kao K, Regnier M. Measuring the Contractile Kinetics of Isolated Myofibrils from Human-Induced Pluripotent Stem Cell Derived Cardiomyocyte (hiPSC-CM) Models of Cardiomyopathy. Methods Mol Biol. 2024;2735:213-233. doi: 10.1007/978-1-0716-3527-8_12. PubMed PMID: 38038851.

Childers MC, Regnier M. Atomistic Simulations of Sarcomere Proteins. Methods Mol Biol. 2024;2735:27-41. doi: 10.1007/978-1-0716-3527-8_3. PubMed PMID: 38038842.

Kao K, Geeves MA. Protocols for Myosin and Actin-Myosin Assays Using Rapid, Stopped-Flow Kinetics. Methods Mol Biol. 2024;2735:191-211. doi: 10.1007/978-1-0716-3527-8_11. PubMed PMID: 38038850.

Hock MT, Teitgen AE, McCabe KJ, Hirakis SP, Huber GA, Regnier M, Amaro RE, McCammon JA, McCulloch AD. Multiscale computational modeling of the effects of 2′-deoxy-ATP on cardiac muscle calcium handling. J Appl Phys. 2023 Aug 21;134(7):074905. doi: 10.1063/5.0157935. Epub 2023 Aug 16. PubMed PMID: 37601331; PubMed Central PMCID: PMC10435275.

Benasutti H, Maricelli JW, Seto J, Hall J, Halbert C, Wicki J, Heusgen L, Purvis N, Regnier M, Lin DC, Rodgers BD, Chamberlain JS. Efficacy and muscle safety assessment of fukutin-related protein gene therapy. Mol Ther Methods Clin Dev. 2023 Sep 14;30:65-80. doi: 10.1016/j.omtm.2023.05.022. eCollection 2023 Sep 14. PubMed PMID: 37361354; PubMed Central PMCID: PMC10285450.

Kooiker KB, Mohran S, Turner KL, Ma W, Martinson A, Flint G, Qi L, Gao C, Zheng Y, McMillen TS, Mandrycky C, Mahoney-Schaefer M, Freeman JC, Costales Arenas EG, Tu AY, Irving TC, Geeves MA, Tanner BCW, Regnier M, Davis J, Moussavi-Harami F. Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle. Circ Res. 2023 Aug 18;133(5):430-443. doi: 10.1161/CIRCRESAHA.123.322629. Epub 2023 Jul 20. PubMed PMID: 37470183; PubMed Central PMCID: PMC10434831.

Chong JX, Childers MC, Marvin CT, Marcello AJ, Gonorazky H, Hazrati LN, Dowling JJ, Al Amrani F, Alanay Y, Nieto Y, Gabriel MÁM, Aylsworth AS, Buckingham KJ, Shively KM, Sommers O, Anderson K, Regnier M, Bamshad MJ. Variants in ACTC1 underlie distal arthrogryposis accompanied by congenital heart defects. HGG Adv. 2023 Jul 13;4(3):100213. doi: 10.1016/j.xhgg.2023.100213. eCollection 2023 Jul 13. PubMed PMID: 37457373; PubMed Central PMCID: PMC10345160.

Wang H, Swore J, Sharma S, Szymanski JR, Yuste R, Daniel TL, Regnier M, Bosma MM, Fairhall AL. A complete biomechanical model of Hydra contractile behaviors, from neural drive to muscle to movement. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2210439120. doi: 10.1073/pnas.2210439120. Epub 2023 Mar 10. PubMed PMID: 36897982; PubMed Central PMCID: PMC10089167.

Pioner JM, Vitale G, Steczina S, Langione M, Margara F, Santini L, Giardini F, Lazzeri E, Piroddi N, Scellini B, Palandri C, Schuldt M, Spinelli V, Girolami F, Mazzarotto F, van der Velden J, Cerbai E, Tesi C, Olivotto I, Bueno-Orovio A, Sacconi L, Coppini R, Ferrantini C, Regnier M, Poggesi C. Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM. Circ Res. 2023 Mar 3;132(5):628-644. doi: 10.1161/CIRCRESAHA.122.321956. Epub 2023 Feb 6. PubMed PMID: 36744470; PubMed Central PMCID: PMC9977265.

Pioner JM, Santini L, Palandri C, Langione M, Grandinetti B, Querceto S, Martella D, Mazzantini C, Scellini B, Giammarino L, Lupi F, Mazzarotto F, Gowran A, Rovina D, Santoro R, Pompilio G, Tesi C, Parmeggiani C, Regnier M, Cerbai E, Mack DL, Poggesi C, Ferrantini C, Coppini R. Corrigendum: Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: the impact of full-length dystrophin deficiency. Front Physiol. 2023;14:1222400. doi: 10.3389/fphys.2023.1222400. eCollection 2023. PubMed PMID: 37383144; PubMed Central PMCID: PMC10296155.

Ma W, You S, Regnier M, McCammon JA. Integrating comparative modeling and accelerated simulations reveals conformational and energetic basis of actomyosin force generation. Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2215836120. doi: 10.1073/pnas.2215836120. Epub 2023 Feb 21. PubMed PMID: 36802417; PubMed Central PMCID: PMC9992861.

Ma W, McMillen TS, Childers MC, Gong H, Regnier M, Irving T. Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2207615120. doi: 10.1073/pnas.2207615120. Epub 2023 Jan 25. PubMed PMID: 36696446; PubMed Central PMCID: PMC9945958.

Gong HM, Ma W, Regnier M, Irving TC. Thick filament activation is different in fast- and slow-twitch skeletal muscle. J Physiol. 2022 Dec;600(24):5247-5266. doi: 10.1113/JP283574. Epub 2022 Nov 23. PubMed PMID: 36342015; PubMed Central PMCID: PMC9772099.

Pioner JM, Santini L, Palandri C, Langione M, Grandinetti B, Querceto S, Martella D, Mazzantini C, Scellini B, Giammarino L, Lupi F, Mazzarotto F, Gowran A, Rovina D, Santoro R, Pompilio G, Tesi C, Parmeggiani C, Regnier M, Cerbai E, Mack DL, Poggesi C, Ferrantini C, Coppini R. Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: The impact of full-length dystrophin deficiency. Front Physiol. 2022;13:1030920. doi: 10.3389/fphys.2022.1030920. eCollection 2022. PubMed PMID: 36419836; PubMed Central PMCID: PMC9676373.

Childers MC, Regnier M, Bothwell M, Smith AST. Conformational sampling of CMT-2D associated GlyRS mutations. Brain Multiphys. 2022;3. doi: 10.1016/j.brain.2022.100054. Epub 2022 Sep 6. PubMed PMID: 36504507; PubMed Central PMCID: PMC9731397.

Landim-Vieira M, Childers MC, Wacker AL, Garcia MR, He H, Singh R, Brundage EA, Johnston JR, Whitson BA, Chase PB, Janssen PM. Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts. Elife. 2022 May 3;11:e74919.

Querceto S, Santoro R, Gowran A, Grandinetti B, Pompilio G, Regnier M, Tesi C, Poggesi C, Ferrantini C, Pioner JM. The harder the climb the better the view: The impact of substrate stiffness on cardiomyocyte fate. J Mol Cell Cardiol Feb 2022; 166:36-49. org/10.1016/j.yjmcc.2022.02.001.

Walklate J, Kao K, Regnier M, Geeves MA. Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch and cardiac muscle. J Biol Chem, Jan 25;298(3):101640. doi: 10.1016/j.jbc.2022.101640. Online ahead of print. PMID: 35090895.

Prodanovic M, Geeves MA, Poggesi C, Regnier M, Mijailovich SM. Effect of myosin isoforms on cardiac muscle twitch of mice, rats and humans. Intern J Molec Sci. 2022. Jan 20;23(3):1135. doi: 10.3390/ijms23031135. PMID: 35163054.

Reichardt IM, Robeson KZ, Regnier M, Davis J. Controlling cardiac fibrosis through fibroblast state space modulation. Cell Signal. 2021 Mar;79:109888. doi: 10.1016/j.cellsig.2020.109888. Epub 2020 Dec 16. PMID: 33340659.

Childers MC, Geeves M, Daggett V, Regnier M. Modulation of post-powerstroke dynamics in myosin II by 2′-deoxy-ADP. Arch Biochem Biophys. 2020 Dec 31;699:108733. doi: 10.1016/j.abb.2020.108733. Epub ahead of print. PMID: 33388313.
McCabe KJ, Aboelkassem Y, Teitgen AE, Huber GA, McCammon JA, Regnier M, McCulloch AD. Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere. Arch Biochem Biophys. 2020 Nov 30;695:108582. doi: 10.1016/j.abb.2020.108582. Epub 2020 Sep 18. PMID: 32956632; PMCID: PMC7721865.
Powers JD, Kooiker KB, Mason AB, Teitgen AE, Flint GV, Tardiff JC, Schwartz SD, McCulloch AD, Regnier M, Davis J, Moussavi-Harami F. Modulating the tension- time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts. JCI Insight. 2020 Oct 15;5(20):e142446. doi: 10.1172/jci.insight.142446. PMID: 32931484; PMCID: PMC7605524.
Ma W, Childers M, Murray J, Moussavi-Harami F, Gong H, Weiss R, Daggett V, Irving T, Regnier M. Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2′-deoxy-ATP. J Physiol. 2020 Nov;598(22):5165-5182. doi: 10.1113/JP280402. Epub 2020 Sep 9. PMID: 32818298; PMCID: PMC7719615.
Doran MH, Pavadai E, Rynkiewicz MJ, Walklate J, Bullitt E, Moore JR, Regnier M, Geeves MA, Lehman W. Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophys J. 2020 Aug 18;119(4):821-830. doi: 10.1016/j.bpj.2020.07.006. Epub 2020 Jul 16. PMID: 32730789; PMCID: PMC7451941.
Shao D, Kolwicz SC Jr, Wang P, Roe ND, Villet O, Nishi K, Hsu YA, Flint GV, Caudal A, Wang W, Regnier M, Tian R. Increasing Fatty Acid Oxidation Prevents High-Fat Diet-Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy. Circulation. 2020 Sep 8;142(10):983-997. doi: 10.1161/CIRCULATIONAHA.119.043319. Epub 2020 Jun 29. PMID: 32597196; PMCID: PMC7484440.
Kolwicz SC Jr, Hall JK, Moussavi-Harami F, Chen X, Hauschka SD, Chamberlain JS, Regnier M, Odom GL. Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate. JACC Basic Transl Sci. 2019 Oct 2;4(7):778-791. doi: 10.1016/j.jacbts.2019.06.006. PMID: 31998848; PMCID: PMC6978556.
Quarles E, Basisty N, Chiao YA, Merrihew G, Gu H, Sweetwyne MT, Fredrickson J, Nguyen NH, Razumova M, Kooiker K, Moussavi-Harami F, Regnier M, Quarles C, MacCoss M, Rabinovitch PS. Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment. Aging Cell. 2020 Feb;19(2):e13086. doi: 10.1111/acel.13086. Epub 2019 Dec 10. PMID: 31823466; PMCID: PMC6996961.

Zaunbrecher RJ, Abel AN, Beussman K, Leonard A, von Frieling-Salewsky M, Fields PA, Pabon L, Reinecke H, Yang X, Macadangdang J, Kim DH, Linke WA, Sniadecki NJ, Regnier M, Murry CE. Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function. Circulation. 2019 Nov 12;140(20):1647-1660. doi: 10.1161/CIRCULATIONAHA.119.039521. Epub 2019 Oct 7. PubMed PMID: 31587567.
Aboelkassem Y, McCabe KJ, Huber GA, Regnier M, McCammon JA, McCulloch AD. A Stochastic Multiscale Model of Cardiac Thin Filament Activation Using Brownian-Langevin Dynamics. Biophys J. 2019 Aug 9;. doi: 10.1016/j.bpj.2019.08.003. [Epub ahead of print] PubMed PMID: 31547973.
Pioner JM, Santini L, Palandri C, Martella D, Lupi F, Langione M, Querceto S, Grandinetti B, Balducci V, Benzoni P, Landi S, Barbuti A, Ferrarese Lupi F, Boarino L, Sartiani L, Tesi C, Mack DL, Regnier M, Cerbai E, Parmeggiani C, Poggesi C, Ferrantini C, Coppini R. Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates. Int J Mol Sci. 2019 Aug 3;20(15). doi: 10.3390/ijms20153799. PubMed PMID: 31382622; PubMed Central PMCID: PMC6695920.
Bargehr J, Ong LP, Colzani M, Davaapil H, Hofsteen P, Bhandari S, Gambardella L, Le Novère N, Iyer D, Sampaziotis F, Weinberger F, Bertero A, Leonard A, Bernard WG, Martinson A, Figg N, Regnier M, Bennett MR, Murry CE, Sinha S. Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration. Nat Biotechnol. 2019 Aug;37(8):895-906. doi: 10.1038/s41587-019-0197-9. Epub 2019 Aug 2. PubMed PMID: 31375810; PubMed Central PMCID: PMC6824587.
Powers JD, Yuan CC, McCabe KJ, Murray JD, Childers MC, Flint GV, Moussavi-Harami F, Mohran S, Castillo R, Zuzek C, Ma W, Daggett V, McCulloch AD, Irving TC, Regnier M. Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11502-11507. doi: 10.1073/pnas.1905028116. Epub 2019 May 20. PubMed PMID: 31110001; PubMed Central PMCID: PMC6561254.
Pioner JM, Guan X, Klaiman JM, Racca AW, Pabon L, Muskheli V, Macadangdang J, Ferrantini C, Hoopmann MR, Moritz RL, Kim DH, Tesi C, Poggesi C, Murry CE, Childers MK, Mack DL, Regnier M. Absence of full-length dystrophin impairs normal maturation and contraction of cardiomyocytes derived from human-induced pluripotent stem cells. Cardiovasc Res. 2020 Feb 1;116(2):368-382. doi: 10.1093/cvr/cvz109. PubMed PMID: 31049579.
Kim MJ, Bible KL, Regnier M, Adams ME, Froehner SC, Whitehead NP. Simvastatin provides long-term improvement of left ventricular function and prevents cardiac fibrosis in muscular dystrophy. Physiol Rep. 2019 Mar;7(6):e14018. doi: 10.14814/phy2.14018. PubMed PMID: 30912308; PubMed Central PMCID: PMC6434171.

Yang KC, Breitbart A, De Lange WJ, Hofsteen P, Futakuchi-Tsuchida A, Xu J, Schopf C, Razumova MV, Jiao A, Boucek R, Pabon L, Reinecke H, Kim DH, Ralphe JC, Regnier M, Murry CE. Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells. JACC Basic Transl Sci. 2018 Dec;3(6):728-740. doi: 10.1016/j.jacbts.2018.08.008. eCollection 2018 Dec. PubMed PMID: 30623132; PubMed Central PMCID: PMC6314962.
Regnier M. Mechanistic complexity of contractile dysfunction in hypertrophic cardiomyopathy. J Gen Physiol. 2018 Aug 6;150(8):1051-1053. doi: 10.1085/jgp.201812091. Epub 2018 Jul 23. PubMed PMID: 30037852; PubMed Central PMCID: PMC6080894.
Powers JD, Williams CD, Regnier M, Daniel TL. A Spatially Explicit Model Shows How Titin Stiffness Modulates Muscle Mechanics and Energetics. Integr Comp Biol. 2018 Aug 1;58(2):186-193. doi: 10.1093/icb/icy055. PubMed PMID: 29897447; PubMed Central PMCID: PMC6104699.
Leonard A, Bertero A, Powers JD, Beussman KM, Bhandari S, Regnier M, Murry CE, Sniadecki NJ. Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues. J Mol Cell Cardiol. 2018 May;118:147-158. doi: 10.1016/j.yjmcc.2018.03.016. Epub 2018 Mar 28. PubMed PMID: 29604261; PubMed Central PMCID: PMC5940558.

Olafsson S, Whittington D, Murray J, Regnier M, Moussavi-Harami F. Fast and sensitive HPLC-MS/MS method for direct quantification of intracellular deoxyribonucleoside triphosphates from tissue and cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:90-97. doi: 10.1016/j.jchromb.2017.10.008. Epub 2017 Oct 5. PubMed PMID: 29032043; PubMed Central PMCID: PMC5698104.
Nowakowski SG, Regnier M, Daggett V. Molecular mechanisms underlying deoxy-ADP.Pi activation of pre-powerstroke myosin. Protein Sci. 2017 Apr;26(4):749-762. doi: 10.1002/pro.3121. Epub 2017 Mar 21. PubMed PMID: 28097776; PubMed Central PMCID: PMC5368076.
Dewan S, McCabe KJ, Regnier M, McCulloch AD. Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants-Genotype to Cellular Phenotype. Front Physiol. 2017;8:151. doi: 10.3389/fphys.2017.00151. eCollection 2017. Review. PubMed PMID: 28352236; PubMed Central PMCID: PMC5348544.
Zieba J, Zhang W, Chong JX, Forlenza KN, Martin JH, Heard K, Grange DK, Butler MG, Kleefstra T, Lachman RS, Nickerson D, Regnier M, Cohn DH, Bamshad M, Krakow D. A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFβ signaling and cause autosomal dominant spondylocarpotarsal synostosis. Sci Rep. 2017 Feb 16;7:41803. doi: 10.1038/srep41803. PubMed PMID: 28205584; PubMed Central PMCID: PMC5311977.
Teichman SL, Thomson KS, Regnier M. Cardiac Myosin Activation with Gene Therapy Produces Sustained Inotropic Effects and May Treat Heart Failure with Reduced Ejection Fraction. Handb Exp Pharmacol. 2017;243:447-464. doi: 10.1007/164_2016_31. Review. PubMed PMID: 27590227; PubMed Central PMCID: PMC5527752.

Thomson KS, Odom GL, Murry CE, Mahairas GG, Moussavi-Harami F, Teichman SL, Chen X, Hauschka SD, Chamberlain JS, Regnier M. Translation of Cardiac Myosin Activation with 2-deoxy-ATP to Treat Heart Failure via an Experimental Ribonucleotide Reductase-Based Gene Therapy. JACC Basic Transl Sci. 2016 Dec;1(7):666-679. doi: 10.1016/j.jacbts.2016.07.006. PubMed PMID: 28553667; PubMed Central PMCID: PMC5444879.
Zaunbrecher R, Regnier M. Connecting Sarcomere Protein Mutations to Pathogenesis in Cardiomyopathies: The Development of “Disease in a Dish” Models. Front Physiol. 2016;7:566. doi: 10.3389/fphys.2016.00566. eCollection 2016. PubMed PMID: 27920728; PubMed Central PMCID: PMC5118458.
Ruan JL, Tulloch NL, Razumova MV, Saiget M, Muskheli V, Pabon L, Reinecke H, Regnier M, Murry CE. Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue. Circulation. 2016 Nov 15;134(20):1557-1567. doi: 10.1161/CIRCULATIONAHA.114.014998. Epub 2016 Oct 13. PubMed PMID: 27737958; PubMed Central PMCID: PMC5123912.
Carson D, Hnilova M, Yang X, Nemeth CL, Tsui JH, Smith AS, Jiao A, Regnier M, Murry CE, Tamerler C, Kim DH. Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells. ACS Appl Mater Interfaces. 2016 Aug 31;8(34):21923-32. doi: 10.1021/acsami.5b11671. Epub 2016 Feb 11. PubMed PMID: 26866596; PubMed Central PMCID: PMC5681855.
Dewan S, McCabe KJ, Regnier M, McCulloch AD, Lindert S. Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation-An Integrated Multiscale Modeling Study. J Phys Chem B. 2016 Aug 25;120(33):8264-75. doi: 10.1021/acs.jpcb.6b01950. Epub 2016 May 6. PubMed PMID: 27133568; PubMed Central PMCID: PMC5001916.
Cheng Y, Lindert S, Oxenford L, Tu AY, McCulloch AD, Regnier M. Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation. J Phys Chem B. 2016 Aug 25;120(33):8238-53. doi: 10.1021/acs.jpcb.6b01859. Epub 2016 May 18. PubMed PMID: 27150586; PubMed Central PMCID: PMC5001945.
Cheng Y, Regnier M. Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility. Arch Biochem Biophys. 2016 Jul 1;601:11-21. doi: 10.1016/j.abb.2016.02.004. Epub 2016 Feb 4. Review. PubMed PMID: 26851561; PubMed Central PMCID: PMC4899195.
Pioner JM, Racca AW, Klaiman JM, Yang KC, Guan X, Pabon L, Muskheli V, Zaunbrecher R, Macadangdang J, Jeong MY, Mack DL, Childers MK, Kim DH, Tesi C, Poggesi C, Murry CE, Regnier M. Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cell Reports. 2016 Jun 14;6(6):885-896. doi: 10.1016/j.stemcr.2016.04.006. Epub 2016 May 5. PubMed PMID: 27161364; PubMed Central PMCID: PMC4911495.
Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, Molkentin JD. A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell. 2016 May 19;165(5):1147-1159. doi: 10.1016/j.cell.2016.04.002. Epub 2016 Apr 21. PubMed PMID: 27114035; PubMed Central PMCID: PMC4874838.
Roberts MA, Tran D, Coulombe KL, Razumova M, Regnier M, Murry CE, Zheng Y. Stromal Cells in Dense Collagen Promote Cardiomyocyte and Microvascular Patterning in Engineered Human Heart Tissue. Tissue Eng Part A. 2016 Apr;22(7-8):633-44. doi: 10.1089/ten.TEA.2015.0482. Epub 2016 Mar 31. PubMed PMID: 26955856; PubMed Central PMCID: PMC4840925.
Regnier M, Cheng Y. Finally, We Can Relax: A New Generation of Muscle Models that Incorporate Sarcomere Compliance. Biophys J. 2016 Feb 2;110(3):521-522. doi: 10.1016/j.bpj.2015.12.025. PubMed PMID: 26840717; PubMed Central PMCID: PMC4744169.
Kolwicz SC Jr, Odom GL, Nowakowski SG, Moussavi-Harami F, Chen X, Reinecke H, Hauschka SD, Murry CE, Mahairas GG, Regnier M. AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility. Mol Ther. 2016 Feb;24(2):240-250. doi: 10.1038/mt.2015.176. Epub 2015 Sep 21. PubMed PMID: 26388461; PubMed Central PMCID: PMC4817808.
Racca AW, Klaiman JM, Pioner JM, Cheng Y, Beck AE, Moussavi-Harami F, Bamshad MJ, Regnier M. Contractile properties of developing human fetal cardiac muscle. J Physiol. 2016 Jan 15;594(2):437-52. doi: 10.1113/JP271290. Epub 2015 Dec 7. PubMed PMID: 26460603; PubMed Central PMCID: PMC4713728.
Cheng Y, Hogarth KA, O’Sullivan ML, Regnier M, Pyle WG. 2-Deoxyadenosine triphosphate restores the contractile function of cardiac myofibril from adult dogs with naturally occurring dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2016 Jan 1;310(1):H80-91. doi: 10.1152/ajpheart.00530.2015. Epub 2015 Oct 23. PubMed PMID: 26497964; PubMed Central PMCID: PMC4796460.

Cheng Y, Rao V, Tu AY, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M. Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation. J Biol Chem. 2015 Nov 13;290(46):27749-66. doi: 10.1074/jbc.M115.683045. Epub 2015 Sep 21. PubMed PMID: 26391394; PubMed Central PMCID: PMC4646022.
Rohani MG, McMahan RS, Razumova MV, Hertz AL, Cieslewicz M, Pun SH, Regnier M, Wang Y, Birkland TP, Parks WC. MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages. J Invest Dermatol. 2015 Oct;135(10):2377-2384. doi: 10.1038/jid.2015.167. Epub 2015 Apr 30. PubMed PMID: 25927164; PubMed Central PMCID: PMC4567949.
Kadota S, Carey J, Reinecke H, Leggett J, Teichman S, Laflamme MA, Murry CE, Regnier M, Mahairas GG. Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure. Eur J Heart Fail. 2015 Aug;17(8):772-81. doi: 10.1002/ejhf.270. Epub 2015 Apr 15. PubMed PMID: 25876005; PubMed Central PMCID: PMC5523878.
Ruan JL, Tulloch NL, Saiget M, Paige SL, Razumova MV, Regnier M, Tung KC, Keller G, Pabon L, Reinecke H, Murry CE. Mechanical Stress Promotes Maturation of Human Myocardium From Pluripotent Stem Cell-Derived Progenitors. Stem Cells. 2015 Jul;33(7):2148-57. doi: 10.1002/stem.2036. Epub 2015 May 11. PubMed PMID: 25865043; PubMed Central PMCID: PMC4478130.
Racca AW, Beck AE, McMillin MJ, Korte FS, Bamshad MJ, Regnier M. The embryonic myosin R672C mutation that underlies Freeman-Sheldon syndrome impairs cross-bridge detachment and cycling in adult skeletal muscle. Hum Mol Genet. 2015 Jun 15;24(12):3348-58. doi: 10.1093/hmg/ddv084. Epub 2015 Mar 3. PubMed PMID: 25740846; PubMed Central PMCID: PMC4481580.
Lehman W, Medlock G, Li XE, Suphamungmee W, Tu AY, Schmidtmann A, Ujfalusi Z, Fischer S, Moore JR, Geeves MA, Regnier M. Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain. Arch Biochem Biophys. 2015 Apr 1;571:10-5. doi: 10.1016/j.abb.2015.02.026. Epub 2015 Feb 26. PubMed PMID: 25726728; PubMed Central PMCID: PMC4385494.
Scellini B, Piroddi N, Flint GV, Regnier M, Poggesi C, Tesi C. Impact of tropomyosin isoform composition on fast skeletal muscle thin filament regulation and force development. J Muscle Res Cell Motil. 2015 Feb;36(1):11-23. doi: 10.1007/s10974-014-9394-9. Epub 2014 Nov 8. PubMed PMID: 25380572.
Moussavi-Harami F, Razumova MV, Racca AW, Cheng Y, Stempien-Otero A, Regnier M. 2-Deoxy adenosine triphosphate improves contraction in human end-stage heart failure. J Mol Cell Cardiol. 2015 Feb;79:256-63. doi: 10.1016/j.yjmcc.2014.12.002. Epub 2014 Dec 10. PubMed PMID: 25498214; PubMed Central PMCID: PMC4301986.
Lindert S, Cheng Y, Kekenes-Huskey P, Regnier M, McCammon JA. Effects of HCM cTnI mutation R145G on troponin structure and modulation by PKA phosphorylation elucidated by molecular dynamics simulations. Biophys J. 2015 Jan 20;108(2):395-407. doi: 10.1016/j.bpj.2014.11.3461. PubMed PMID: 25606687; PubMed Central PMCID: PMC4302190.
Cheng Y, Lindert S, Kekenes-Huskey P, Rao VS, Solaro RJ, Rosevear PR, Amaro R, McCulloch AD, McCammon JA, Regnier M. Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics. Biophys J. 2014 Oct 7;107(7):1675-85. doi: 10.1016/j.bpj.2014.08.008. PubMed PMID: 25296321; PubMed Central PMCID: PMC4190606.
Rao V, Cheng Y, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M. PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils. Biophys J. 2014 Sep 2;107(5):1196-1204. doi: 10.1016/j.bpj.2014.07.027. PubMed PMID: 25185555; PubMed Central PMCID: PMC4156663.
Lundy SD, Murphy SA, Dupras SK, Dai J, Murry CE, Laflamme MA, Regnier M. Cell-based delivery of dATP via gap junctions enhances cardiac contractility. J Mol Cell Cardiol. 2014 Jul;72:350-9. doi: 10.1016/j.yjmcc.2014.04.010. Epub 2014 Apr 26. PubMed PMID: 24780238; PubMed Central PMCID: PMC4073675.
Feest ER, Steven Korte F, Tu AY, Dai J, Razumova MV, Murry CE, Regnier M. Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts. J Mol Cell Cardiol. 2014 Jul;72:219-27. doi: 10.1016/j.yjmcc.2014.03.015. Epub 2014 Mar 29. PubMed PMID: 24690333; PubMed Central PMCID: PMC4082830.
Yang X, Rodriguez M, Pabon L, Fischer KA, Reinecke H, Regnier M, Sniadecki NJ, Ruohola-Baker H, Murry CE. Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells. J Mol Cell Cardiol. 2014 Jul;72:296-304. doi: 10.1016/j.yjmcc.2014.04.005. Epub 2014 Apr 13. PubMed PMID: 24735830; PubMed Central PMCID: PMC4041732.
Regnier M. Biophysical and biomechanical properties of myofilament proteins. Arch Biochem Biophys. 2014 Jun 15;552-553:1-2. doi: 10.1016/j.abb.2014.05.018. PubMed PMID: 24890820.
Macadangdang J, Lee HJ, Carson D, Jiao A, Fugate J, Pabon L, Regnier M, Murry C, Kim DH. Capillary force lithography for cardiac tissue engineering. J Vis Exp. 2014 Jun 10;(88). doi: 10.3791/50039. PubMed PMID: 24962161; PubMed Central PMCID: PMC4188383.
Thomson KS, Dupras SK, Murry CE, Scatena M, Regnier M. Proangiogenic microtemplated fibrin scaffolds containing aprotinin promote improved wound healing responses. Angiogenesis. 2014 Jan;17(1):195-205. doi: 10.1007/s10456-013-9388-z. Epub 2013 Oct 15. PubMed PMID: 24127199; PubMed Central PMCID: PMC3888647.
Rodriguez AG, Rodriguez ML, Han SJ, Sniadecki NJ, Regnier M. Enhanced contractility with 2-deoxy-ATP and EMD 57033 is correlated with reduced myofibril structure and twitch power in neonatal cardiomyocytes. Integr Biol (Camb). 2013 Nov;5(11):1366-73. doi: 10.1039/c3ib40135a. Epub 2013 Sep 10. PubMed PMID: 24056444; PubMed Central PMCID: PMC5314959.
Williams CD, Salcedo MK, Irving TC, Regnier M, Daniel TL. The length-tension curve in muscle depends on lattice spacing. Proc Biol Sci. 2013 Sep 7;280(1766):20130697. doi: 10.1098/rspb.2013.0697. Print 2013 Sep 7. PubMed PMID: 23843386; PubMed Central PMCID: PMC3730583.
Lundy SD, Zhu WZ, Regnier M, Laflamme MA. Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells. Stem Cells Dev. 2013 Jul 15;22(14):1991-2002. doi: 10.1089/scd.2012.0490. Epub 2013 Apr 5. PubMed PMID: 23461462; PubMed Central PMCID: PMC3699903.
Wang D, McCully ME, Luo Z, McMichael J, Tu AY, Daggett V, Regnier M. Structural and functional consequences of cardiac troponin C L57Q and I61Q Ca(2+)-desensitizing variants. Arch Biochem Biophys. 2013 Jul 1;535(1):68-75. doi: 10.1016/j.abb.2013.02.006. Epub 2013 Feb 28. PubMed PMID: 23454346; PubMed Central PMCID: PMC3657564.
Racca AW, Beck AE, Rao VS, Flint GV, Lundy SD, Born DE, Bamshad MJ, Regnier M. Contractility and kinetics of human fetal and human adult skeletal muscle. J Physiol. 2013 Jun 15;591(12):3049-61. doi: 10.1113/jphysiol.2013.252650. Epub 2013 Apr 29. PubMed PMID: 23629510; PubMed Central PMCID: PMC3832119.
Nowakowski SG, Kolwicz SC, Korte FS, Luo Z, Robinson-Hamm JN, Page JL, Brozovich F, Weiss RS, Tian R, Murry CE, Regnier M. Transgenic overexpression of ribonucleotide reductase improves cardiac performance. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6187-92. doi: 10.1073/pnas.1220693110. Epub 2013 Mar 25. PubMed PMID: 23530224; PubMed Central PMCID: PMC3625337.
Thomson KS, Korte FS, Giachelli CM, Ratner BD, Regnier M, Scatena M. Prevascularized microtemplated fibrin scaffolds for cardiac tissue engineering applications. Tissue Eng Part A. 2013 Apr;19(7-8):967-77. doi: 10.1089/ten.tea.2012.0286. Epub 2013 Jan 14. PubMed PMID: 23317311; PubMed Central PMCID: PMC3589898.
Beck AE, McMillin MJ, Gildersleeve HI, Kezele PR, Shively KM, Carey JC, Regnier M, Bamshad MJ. Spectrum of mutations that cause distal arthrogryposis types 1 and 2B. Am J Med Genet A. 2013 Mar;161A(3):550-5. doi: 10.1002/ajmg.a.35809. Epub 2013 Feb 7. PubMed PMID: 23401156; PubMed Central PMCID: PMC3581718.
Rao VS, Korte FS, Razumova MV, Feest ER, Hsu H, Irving TC, Regnier M, Martyn DA. N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle. J Physiol. 2013 Jan 15;591(2):475-90. doi: 10.1113/jphysiol.2012.241604. Epub 2012 Nov 5. PubMed PMID: 23129792; PubMed Central PMCID: PMC3577517.
Williams CD, Regnier M, Daniel TL. Elastic energy storage and radial forces in the myofilament lattice depend on sarcomere length. PLoS Comput Biol. 2012;8(11):e1002770. doi: 10.1371/journal.pcbi.1002770. Epub 2012 Nov 15. PubMed PMID: 23166482; PubMed Central PMCID: PMC3499250.
Korte FS, Feest ER, Razumova MV, Tu AY, Regnier M. Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges. Am J Physiol Heart Circ Physiol. 2012 Oct 1;303(7):H863-70. doi: 10.1152/ajpheart.00395.2012. Epub 2012 Aug 3. PubMed PMID: 22865385; PubMed Central PMCID: PMC3469702.
Wang D, Robertson IM, Li MX, McCully ME, Crane ML, Luo Z, Tu AY, Daggett V, Sykes BD, Regnier M. Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation. Biochemistry. 2012 Jun 5;51(22):4473-87. doi: 10.1021/bi3003007. Epub 2012 May 23. PubMed PMID: 22591429; PubMed Central PMCID: PMC3437384.
Tanner BC, Daniel TL, Regnier M. Filament compliance influences cooperative activation of thin filaments and the dynamics of force production in skeletal muscle. PLoS Comput Biol. 2012;8(5):e1002506. doi: 10.1371/journal.pcbi.1002506. Epub 2012 May 10. PubMed PMID: 22589710; PubMed Central PMCID: PMC3349719.
Liu Y, Korte FS, Moussavi-Harami F, Yu M, Razumova M, Regnier M, Chin MT. Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6. Am J Physiol Heart Circ Physiol. 2012 May 1;302(9):H1860-70. doi: 10.1152/ajpheart.00702.2011. Epub 2012 Mar 9. PubMed PMID: 22408025; PubMed Central PMCID: PMC3362059.
Korte FS, Dai J, Buckley K, Feest ER, Adamek N, Geeves MA, Murry CE, Regnier M. Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation. J Mol Cell Cardiol. 2011 Dec;51(6):894-901. doi: 10.1016/j.yjmcc.2011.08.026. Epub 2011 Sep 3. PubMed PMID: 21925507; PubMed Central PMCID: PMC3208740.
Rodriguez AG, Han SJ, Regnier M, Sniadecki NJ. Substrate stiffness increases twitch power of neonatal cardiomyocytes in correlation with changes in myofibril structure and intracellular calcium. Biophys J. 2011 Nov 16;101(10):2455-64. doi: 10.1016/j.bpj.2011.09.057. Epub 2011 Nov 15. PubMed PMID: 22098744; PubMed Central PMCID: PMC3218322.
Tulloch NL, Muskheli V, Razumova MV, Korte FS, Regnier M, Hauch KD, Pabon L, Reinecke H, Murry CE. Growth of engineered human myocardium with mechanical loading and vascular coculture. Circ Res. 2011 Jun 24;109(1):47-59. doi: 10.1161/CIRCRESAHA.110.237206. Epub 2011 May 19. PubMed PMID: 21597009; PubMed Central PMCID: PMC3140796.
Kreutziger KL, Piroddi N, McMichael JT, Tesi C, Poggesi C, Regnier M. Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle. J Mol Cell Cardiol. 2011 Jan;50(1):165-74. doi: 10.1016/j.yjmcc.2010.10.025. Epub 2010 Oct 28. PubMed PMID: 21035455; PubMed Central PMCID: PMC3018540.
Williams CD, Regnier M, Daniel TL. Axial and radial forces of cross-bridges depend on lattice spacing. PLoS Comput Biol. 2010 Dec 2;6(12):e1001018. doi: 10.1371/journal.pcbi.1001018. PubMed PMID: 21152002; PubMed Central PMCID: PMC2996315.
Force T, Bonow RO, Houser SR, Solaro RJ, Hershberger RE, Adhikari B, Anderson ME, Boineau R, Byrne BJ, Cappola TP, Kalluri R, LeWinter MM, Maron MS, Molkentin JD, Ommen SR, Regnier M, Tang WH, Tian R, Konstam MA, Maron BJ, Seidman CE. Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation. 2010 Sep 14;122(11):1130-3. doi: 10.1161/CIRCULATIONAHA.110.950089. PubMed PMID: 20837938; PubMed Central PMCID: PMC3070356.
Moreno-Gonzalez A, Korte FS, Dai J, Chen K, Ho B, Reinecke H, Murry CE, Regnier M. Cell therapy enhances function of remote non-infarcted myocardium. J Mol Cell Cardiol. 2009 Nov;47(5):603-13. doi: 10.1016/j.yjmcc.2009.07.030. Epub 2009 Aug 14. PubMed PMID: 19683533; PubMed Central PMCID: PMC2763233.
Stevens KR, Kreutziger KL, Dupras SK, Korte FS, Regnier M, Muskheli V, Nourse MB, Bendixen K, Reinecke H, Murry CE. Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16568-73. doi: 10.1073/pnas.0908381106. Epub 2009 Sep 17. PubMed PMID: 19805339; PubMed Central PMCID: PMC2746126.
Smith L, Tainter C, Regnier M, Martyn DA. Cooperative cross-bridge activation of thin filaments contributes to the Frank-Starling mechanism in cardiac muscle. Biophys J. 2009 May 6;96(9):3692-702. doi: 10.1016/j.bpj.2009.02.018. PubMed PMID: 19413974; PubMed Central PMCID: PMC3325146.
Razumova MV, Bezold KL, Tu AY, Regnier M, Harris SP. Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculae. J Gen Physiol. 2008 Nov;132(5):575-85. doi: 10.1085/jgp.200810013. PubMed PMID: 18955596; PubMed Central PMCID: PMC2571974.
Kreutziger KL, Piroddi N, Scellini B, Tesi C, Poggesi C, Regnier M. Thin filament Ca2+ binding properties and regulatory unit interactions alter kinetics of tension development and relaxation in rabbit skeletal muscle. J Physiol. 2008 Aug 1;586(15):3683-700. doi: 10.1113/jphysiol.2008.152181. Epub 2008 Jun 5. PubMed PMID: 18535094; PubMed Central PMCID: PMC2538828.
Nitta T, Tanahashi A, Obara Y, Hirano M, Razumova M, Regnier M, Hess H. Comparing guiding track requirements for myosin- and kinesin-powered molecular shuttles. Nano Lett. 2008 Aug;8(8):2305-9. doi: 10.1021/nl8010885. Epub 2008 Jul 18. PubMed PMID: 18636779.
Tanner BC, Regnier M, Daniel TL. A spatially explicit model of muscle contraction explains a relationship between activation phase, power and ATP utilization in insect flight. J Exp Biol. 2008 Jan;211(Pt 2):180-6. doi: 10.1242/jeb.013466. PubMed PMID: 18165245.
Kreutziger KL, Gillis TE, Davis JP, Tikunova SB, Regnier M. Influence of enhanced troponin C Ca2+-binding affinity on cooperative thin filament activation in rabbit skeletal muscle. J Physiol. 2007 Aug 15;583(Pt 1):337-50. doi: 10.1113/jphysiol.2007.135426. Epub 2007 Jun 21. PubMed PMID: 17584846; PubMed Central PMCID: PMC2277218.
Tanner BC, Daniel TL, Regnier M. Sarcomere lattice geometry influences cooperative myosin binding in muscle. PLoS Comput Biol. 2007 Jul;3(7):e115. doi: 10.1371/journal.pcbi.0030115. PubMed PMID: 17630823; PubMed Central PMCID: PMC1914368.
Martyn DA, Smith L, Kreutziger KL, Xu S, Yu LC, Regnier M. The effects of force inhibition by sodium vanadate on cross-bridge binding, force redevelopment, and Ca2+ activation in cardiac muscle. Biophys J. 2007 Jun 15;92(12):4379-90. doi: 10.1529/biophysj.106.096768. Epub 2007 Mar 30. PubMed PMID: 17400698; PubMed Central PMCID: PMC1877787.
Gillis TE, Martyn DA, Rivera AJ, Regnier M. Investigation of thin filament near-neighbour regulatory unit interactions during force development in skinned cardiac and skeletal muscle. J Physiol. 2007 Apr 15;580(Pt. 2):561-76. doi: 10.1113/jphysiol.2007.128975. Epub 2007 Feb 22. PubMed PMID: 17317743; PubMed Central PMCID: PMC2075566.
Shaffer JF, Razumova MV, Tu AY, Regnier M, Harris SP. Myosin S2 is not required for effects of myosin binding protein-C on motility. FEBS Lett. 2007 Apr 3;581(7):1501-4. doi: 10.1016/j.febslet.2007.03.007. Epub 2007 Mar 12. PubMed PMID: 17376443.
Moreno-Gonzalez A, Gillis TE, Rivera AJ, Chase PB, Martyn DA, Regnier M. Thin-filament regulation of force redevelopment kinetics in rabbit skeletal muscle fibres. J Physiol. 2007 Mar 1;579(Pt 2):313-26. doi: 10.1113/jphysiol.2006.124164. Epub 2007 Jan 4. PubMed PMID: 17204497; PubMed Central PMCID: PMC2075405.
Kataoka A, Tanner BC, Macpherson JM, Xu X, Wang Q, Regnier M, Daniel TL, Chase PB. Spatially explicit, nano-mechanical models of the muscle half-sarcomere: Implications for biomechanical tuning in atrophy and fatigue. Acta astronautica. 2007 January; 60(2):111-8.
Razumova MV, Shaffer JF, Tu AY, Flint GV, Regnier M, Harris SP. Effects of the N-terminal domains of myosin binding protein-C in an in vitro motility assay: Evidence for long-lived cross-bridges. J Biol Chem. 2006 Nov 24;281(47):35846-54. doi: 10.1074/jbc.M606949200. Epub 2006 Oct 1. PubMed PMID: 17012744.
Bell MG, Lankford EB, Gonye GE, Ellis-Davies GC, Martyn DA, Regnier M, Barsotti RJ. Kinetics of cardiac thin-filament activation probed by fluorescence polarization of rhodamine-labeled troponin C in skinned guinea pig trabeculae. Biophys J. 2006 Jan 15;90(2):531-43. doi: 10.1529/biophysj.105.072769. Epub 2005 Oct 28. PubMed PMID: 16258047; PubMed Central PMCID: PMC1367058.
Clemmens EW, Entezari M, Martyn DA, Regnier M. Different effects of cardiac versus skeletal muscle regulatory proteins on in vitro measures of actin filament speed and force. J Physiol. 2005 Aug 1;566(Pt 3):737-46. doi: 10.1113/jphysiol.2005.084194. Epub 2005 May 19. PubMed PMID: 15905219; PubMed Central PMCID: PMC1464789.
Clemmens EW, Regnier M. Skeletal regulatory proteins enhance thin filament sliding speed and force by skeletal HMM. J Muscle Res Cell Motil. 2004;25(7):515-25. doi: 10.1007/s10974-004-3787-0. Epub 2005 Feb 9. PubMed PMID: 15711882.
Moreno-Gonzalez A, Fredlund J, Regnier M. Cardiac troponin C (TnC) and a site I skeletal TnC mutant alter Ca2+ versus crossbridge contribution to force in rabbit skeletal fibres. J Physiol. 2005 Feb 1;562(Pt 3):873-84. doi: 10.1113/jphysiol.2004.077891. Epub 2004 Dec 20. PubMed PMID: 15611027; PubMed Central PMCID: PMC1665546.
Regnier M, Martin H, Barsotti RJ, Rivera AJ, Martyn DA, Clemmens E. Cross-bridge versus thin filament contributions to the level and rate of force development in cardiac muscle. Biophys J. 2004 Sep;87(3):1815-24. doi: 10.1529/biophysj.103.039123. PubMed PMID: 15345560; PubMed Central PMCID: PMC1304586.
Adhikari BB, Regnier M, Rivera AJ, Kreutziger KL, Martyn DA. Cardiac length dependence of force and force redevelopment kinetics with altered cross-bridge cycling. Biophys J. 2004 Sep;87(3):1784-94. doi: 10.1529/biophysj.103.039131. PubMed PMID: 15345557; PubMed Central PMCID: PMC1304583.
Martyn DA, Adhikari BB, Regnier M, Gu J, Xu S, Yu LC. Response of equatorial x-ray reflections and stiffness to altered sarcomere length and myofilament lattice spacing in relaxed skinned cardiac muscle. Biophys J. 2004 Feb;86(2):1002-11. doi: 10.1016/S0006-3495(04)74175-2. PubMed PMID: 14747335; PubMed Central PMCID: PMC1303893.
Liang B, Chen Y, Wang CK, Luo Z, Regnier M, Gordon AM, Chase PB. Ca2+ regulation of rabbit skeletal muscle thin filament sliding: role of cross-bridge number. Biophys J. 2003 Sep;85(3):1775-86. doi: 10.1016/S0006-3495(03)74607-4. PubMed PMID: 12944292; PubMed Central PMCID: PMC1303351.
Köhler J, Chen Y, Brenner B, Gordon AM, Kraft T, Martyn DA, Regnier M, Rivera AJ, Wang CK, Chase PB. Familial hypertrophic cardiomyopathy mutations in troponin I (K183D, G203S, K206Q) enhance filament sliding. Physiol Genomics. 2003 Jul 7;14(2):117-28. doi: 10.1152/physiolgenomics.00101.2002. PubMed PMID: 12759477.
Gordon AM, Rivera AJ, Wang CK, Regnier M. Cooperative activation of skeletal and cardiac muscle. Adv Exp Med Biol. 2003;538:371-8; discussion 378-9. doi: 10.1007/978-1-4419-9029-7_34. PubMed PMID: 15098683.
Martyn DA, Chase PB, Regnier M, Gordon AM. A simple model with myofilament compliance predicts activation-dependent crossbridge kinetics in skinned skeletal fibers. Biophys J. 2002 Dec;83(6):3425-34. doi: 10.1016/S0006-3495(02)75342-3. PubMed PMID: 12496109; PubMed Central PMCID: PMC1302417.
Regnier M, Rivera AJ, Wang CK, Bates MA, Chase PB, Gordon AM. Thin filament near-neighbour regulatory unit interactions affect rabbit skeletal muscle steady-state force-Ca(2+) relations. J Physiol. 2002 Apr 15;540(Pt 2):485-97. doi: 10.1113/jphysiol.2001.013179. PubMed PMID: 11956338; PubMed Central PMCID: PMC2290239.
Gordon AM, Regnier M, Homsher E. Skeletal and cardiac muscle contractile activation: tropomyosin “rocks and rolls”. News Physiol Sci. 2001 Apr;16:49-55. Review. PubMed PMID: 11390948.
Sieck GC, Regnier M. Invited Review: plasticity and energetic demands of contraction in skeletal and cardiac muscle. J Appl Physiol (1985). 2001 Mar;90(3):1158-64. doi: 10.1152/jappl.2001.90.3.1158. Review. PubMed PMID: 11181631.
Martyn DA, Regnier M, Xu D, Gordon AM. Ca2+ – and cross-bridge-dependent changes in N- and C-terminal structure of troponin C in rat cardiac muscle. Biophys J. 2001 Jan;80(1):360-70. doi: 10.1016/S0006-3495(01)76020-1. PubMed PMID: 11159408; PubMed Central PMCID: PMC1301239.
Regnier M, Rivera AJ, Chen Y, Chase PB. 2-deoxy-ATP enhances contractility of rat cardiac muscle. Circ Res. 2000 Jun 23;86(12):1211-7. doi: 10.1161/01.res.86.12.1211. PubMed PMID: 10864910.
Gordon AM, Homsher E, Regnier M. Regulation of contraction in striated muscle. Physiol Rev. 2000 Apr;80(2):853-924. doi: 10.1152/physrev.2000.80.2.853. Review. PubMed PMID: 10747208.
Regnier M, Chase PB, Martyn DA. Contractile properties of rabbit psoas muscle fibres inhibited by beryllium fluoride. J Muscle Res Cell Motil. 1999 May;20(4):425-32. doi: 10.1023/a:1005594001334. PubMed PMID: 10531623.
Regnier M, Rivera AJ, Chase PB, Smillie LB, Sorenson MM. Regulation of skeletal muscle tension redevelopment by troponin C constructs with different Ca2+ affinities. Biophys J. 1999 May;76(5):2664-72. doi: 10.1016/S0006-3495(99)77418-7. PubMed PMID: 10233080; PubMed Central PMCID: PMC1300235.
Regnier M, Homsher E. The effect of ATP analogs on posthydrolytic and force development steps in skinned skeletal muscle fibers. Biophys J. 1998 Jun;74(6):3059-71. doi: 10.1016/S0006-3495(98)78013-0. PubMed PMID: 9635760; PubMed Central PMCID: PMC1299647.
Regnier M, Lee DM, Homsher E. ATP analogs and muscle contraction: mechanics and kinetics of nucleoside triphosphate binding and hydrolysis. Biophys J. 1998 Jun;74(6):3044-58. doi: 10.1016/S0006-3495(98)78012-9. PubMed PMID: 9635759; PubMed Central PMCID: PMC1299646.
Regnier M, Martyn DA, Chase PB. Calcium regulation of tension redevelopment kinetics with 2-deoxy-ATP or low [ATP] in rabbit skeletal muscle. Biophys J. 1998 Apr;74(4):2005-15. doi: 10.1016/S0006-3495(98)77907-X. PubMed PMID: 9545059; PubMed Central PMCID: PMC1299541.
Homsher E, Lacktis J, Regnier M. Strain-dependent modulation of phosphate transients in rabbit skeletal muscle fibers. Biophys J. 1997 Apr;72(4):1780-91. doi: 10.1016/S0006-3495(97)78824-6. PubMed PMID: 9083682; PubMed Central PMCID: PMC1184372.
Regnier M, Martyn DA, Chase PB. Calmidazolium alters Ca2+ regulation of tension redevelopment rate in skinned skeletal muscle. Biophys J. 1996 Nov;71(5):2786-94. doi: 10.1016/S0006-3495(96)79471-7. PubMed PMID: 8913615; PubMed Central PMCID: PMC1233764.
Regnier M, Morris C, Homsher E. Regulation of the cross-bridge transition from a weakly to strongly bound state in skinned rabbit muscle fibers. Am J Physiol. 1995 Dec;269(6 Pt 1):C1532-9. doi: 10.1152/ajpcell.1995.269.6.C1532. PubMed PMID: 8572183.
Regnier M, Herrera AA. Differential sensitivity to androgens within a sexually dimorphic muscle of male frogs (Xenopus laevis). J Neurobiol. 1993 Sep;24(9):1215-28. doi: 10.1002/neu.480240908. PubMed PMID: 8409979.
Regnier M, Herrera AA. Changes in contractile properties by androgen hormones in sexually dimorphic muscles of male frogs (Xenopus laevis). J Physiol. 1993 Feb;461:565-81. doi: 10.1113/jphysiol.1993.sp019529. PubMed PMID: 8350275; PubMed Central PMCID: PMC1175273.
Herrera AA, Regnier M. Hormonal Regulation of Motor Systems: How Androgens Control Amplexus (Clasping) in Male Frogs . In: Visual Structures and Integrated Functions. Arbib MA, Ewert J, editors. Berlin: Springer-Verlag; 1991. p.369-379.
Herrera AA, Banner LR, Werle MJ, Regnier M, Nagaya-Stevens N. Postmetamorphic development of neuromuscular junctions and muscle fibers in the frog cutaneous pectoris. J Neurobiol. 1991 Jan;22(1):15-28. doi: 10.1002/neu.480220103. PubMed PMID: 2010747.