Projects

• Molecular Dynamics Simulations
• Stochastic Modeling of Crossbridge Cycling
• Multiscale Muscle Modeling — MUSICO

Related Publications

• Tanner BC, Daniel TL, Regnier M. Filament compliance influences cooperative activation of thin filaments and the dynamics of force production in skeletal muscle. PLoS Comput Biol. 2012;8(5):e1002506. PubMed PMID: 22589710; PubMed Central PMCID: PMC3349719.
• Wang D, Robertson IM, Li MX, McCully ME, Crane ML, Luo Z, Tu AY, Daggett V, Sykes BD, Regnier M. Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation. Biochemistry. 2012 Jun 5;51(22):4473-87. PubMed PMID: 22591429; PubMed Central PMCID: PMC3437384.
• Williams CD, Salcedo MK, Irving TC, Regnier M, Daniel TL. The length-tension curve in muscle depends on lattice spacing. Proc Biol Sci. 2013 Sep 7;280(1766):20130697. PubMed PMID: 23843386; PubMed Central PMCID: PMC3730583.
• Cheng Y, Rao V, Tu AY, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M. Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation. J Biol Chem. 2015 Nov 13;290(46):27749-66. PubMed PMID: 26391394; PubMed Central PMCID: PMC4646022.