Mitochondrial Dynamics

While mitochondria are most known for being the powerhouse of the cell they are also responsible for numerous cellular processes which are critical for cell survival. For example, mitochondria contribute to lipid biogenesis, calcium homeostasis, cell cycle progression and apoptotic cell death. 

Like many things in biochemistry, form is important for function. This same theory applies to mitochondria. Mitochondria form large networks which are constantly fusing, dividing, and moving on microtubules (see image below). These dynamic properties of mitochondria determine shape and position and are critical for maintaining mitochondrial function.

Therefore, it is not surprising that mitochondrial dysfunction is associated with a broad collection of human diseases and disorders including neuropathies, myopathies, diabetes and aging.

In the Hoppins Lab, we are particularly interested in understanding the molecular mechanism of mitochondrial fusion and how fusion is regulated. Our basic research will provide insight into the pathophysiology of disease and potential therapeutic approaches.