AID/DoM Research Collaboratory

ARC Mission

The Allergy & Infectious Diseases (and Department of Medicine) Research Collaboratory (ARC) has three core aims that encapsulate our mission:

  1. To advance knowledge that optimizes how we care for our patients, using data analytics.
  2. To leverage the power of electronic health record (EHR) and understand how to use these data wisely.
  3. To foster a learning health system that trains junior investigators to harness these data into actionable insights.

In this era of “big data,” healthcare data are among the biggest and most complicated for the following reasons:

  • These data live in multiple places
  • They come in diverse forms: both structured and unstructured and
  • One cannot take these data at face value

The clinical enterprise caring for patients is enormously complex. Clinical definitions can be dynamic and subject to an ever-changing evidence base. To manage and transform healthcare data into something usable across a population in a way that can provide actionable insights requires a special set of knowledge and tools. This is where ARC comes in.

Our mission is to help investigators leverage the power of these digital data to generate meaningful evidence that closes the gap between practice and quality care.

 

 

 

Our Data Services

UW Medicine is a large health system that has been capturing clinical data from the electronic health record (EHR) since late 1990s . Since 2008, UW Information Technology has organized and coalesced these data to facilitate multiple clinical, operational and research initiatives across our organization. But, access to the UW Enterprise Data Warehouse (now more accurately known as DEEP) still requires a skilled data analyst to query and extract these data. ARC can assist in accessing this data warehouse and offer advice on data sources, study design, clinical phenotyping and analytic methods. To get started, please complete this:

Leaf is a self-service clinical data discovery tool offered through UW Institute of Translational Health Sciences (ITHS) that provides a powerful data exploratory platform for users to access and explore the UW clinical data directly for research and quality improvement (QI) purposes (with some limitations).

Stats Curbside is a service we offer to junior members of the Division of AID who have not yet established grant funding or have a statistician at their disposal and may have questions related to R coding, data management or analytic questions.

Please note: we are not able to provide statistical support for non-AID members at this time.

ARC Core Team

Dr. Nina Kim, Professor of Medicine in the Division of Allergy & Infectious Diseases (DAID), founded ARC in January 2018 along with Dr. Anna Wald (AID Division head) and Dr. Robert Harrington (Harborview Chief of Medicine). Dr. Kim brings a background in clinical epidemiology, observational research and data science through her work within the UW Center for AIDS Research Clinical Cohort & Comorbidity Research Core.

Kristine Lan is the DAID data analyst and a masters-level biostatistician who trained at the University of Michigan. Ayushi Gupta is the Department of Medicine (DOM) data analyst with a masters in biomedical and health informatics from the University of North Carolina.

Acknowledge ARC

If we were involved in data acquisition/extraction and not in the conception, design or analysis of the project, we do not need to be credited as co-authors (see ICMJE criteria for authorship). But we would appreciate an acknowledgement of our contribution in your manuscript: “We thank {Kristine Lan} for her assistance with data acquisition. This work was made possible by the support of the UW Allergy & Infectious Diseases Research Collaboratory (ARC).”

ARC Publications

  • Mani NS, Lan KF, Jain R, Bryson-Cahn C, Lynch JB, Krantz EM, Bryan A, Liu C, Chan JD, Pottinger PS, Kim HN. Post-Prescription Review with Threat of Infectious Disease Consultation and Sustained Reduction in Meropenem Use Over Four Years. Clin Infect Dis. 2020 Aug 31; doi: 10.1093/cid/ciaa1279. PubMed PMID: 32866224.
  • Imlay H, Krantz EM, Stohs EJ, Lan KF, Zier J, Kim HN, Rakita RM, Limaye AP, Wald A, Pergam SA, Liu C. Reported β-Lactam and Other Antibiotic Allergies in Solid Organ and Hematopoietic Cell Transplant Recipients. Clin Infect Dis. 2020 Oct 23;71(7):1587-1594. PubMed PMID: 31621829.
  • Buckner FS, McCulloch DJ, Atluri V, Blain M, McGuffin SA, Nalla AK, Huang ML, Greninger AL, Jerome KR, Cohen SA, Neme S, Green ML, Chu HY, Kim HN. Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington. Clin Infect Dis. 2020 Nov 19;71(16):2167-2173. PubMed PMID: 32444880.
  • Liu C, Lan K, Krantz EM, Kim HN, Zier J, Bryson-Cahn C, Chan JD, Jain R, Lynch JB, Pergam SA, Pottinger PS, Sweet A, Whimbey E, Bryan A. Improving Appropriate Diagnosis of Clostridioides difficile Infection Through an Enteric Pathogen Order Set With Computerized Clinical Decision Support: An Interrupted Time Series Analysis. Open Forum Infect Dis. 2020 Oct;7(10):ofaa366. PubMed PMID: 33094113.
  • Mani NS, Budak JZ, Lan KF, Bryson-Cahn C, Zelikoff A, Barker GEC, Grant CW, Hart K, Barbee CJ, Sandoval MD, Dostal CL, Corcorran M, Ungerleider HM, Gates JO, Olin SV, Bryan A, Hoffman NG, Marquis SR, Harvey ML, Nasenbeny K, Mertens K, Chew LD, Greninger AL, Jerome KR, Pottinger PS, Dellit TH, Liu C, Pergam SA, Neme S, Lynch JB, Kim HN, Cohen SA. Prevalence of Coronavirus Disease 2019 Infection and Outcomes Among Symptomatic Healthcare Workers in Seattle, Washington. Clin Infect Dis. 2020 Dec 17;71(10):2702-2707. PubMed PMID: 32548613.
  • Wood BR, Lan KF, Tao Y, Mose EY, Aas E, Budak JZ, Dhanireddy S, Kim HN. Visit trends and factors associated with telemedicine uptake among persons with HIV during the COVID-19 pandemic. Open Forum Infect Dis. 2021 Sept;ofab480. PubMed PMID: 34754884.
  • Hill JA, Menon MP, Dhanireddy S, Wurfel MM, Green M, Jain R, Chan JD, Huang J, Bethune D, Turtle C, Johnston C, Xie H, Leisenring WM, Kim HN, Cheng GS. Tocilizumab in hospitalized patients with COVID-19: Clinical outcomes, inflammatory marker kinetics, and safety. J Med Virol. 2021 Apr;93(4):2270-2280. PubMed PMID: 33200828.
  • Kim HN, Lan KF, Nkyekyer E, Neme S, Pierre-Louis M, Chew L, Duber HC. Assessment of Disparities in COVID-19 Testing and Infection Across Language Groups in Seattle, Washington. JAMA Netw Open. 2020 Sep 1;3(9):e2021213.
  • Stalter RM, Atluri V, Xia F, Thomas KK, Lan KF, Greninger AL, Patel RC. Elucidating Pathways Mediating the Relationship Between Male Sex and COVID-19 Severity. Clin Epidemiol. 2022 Jan 25;14:115-125. doi: 10.2147/CLEP.S335494. PMID: 35115840.
  • Kim HN, Gupta A, Lan KF, Stewart J, Dhanireddy S, Corcorran M. Diagnostic Accuracy of ICD Code versus Discharge Summary based Query for Endocarditis Cohort Identification. Medicine. 2022 Jan 28;101(4):e28713. PMID: 34941148.
  • Corcorran MA, Stewart J, Lan K, Gupta A, Glick SN, Seshadri C, Koomalsingh KJ, Gibbons EF, Harrington RD, Dhanireddy S, Kim HN. Correlates of 90-day Mortality Among People Who Do and Do Not Inject Drugs with Infective Endocarditis in Seattle, Washington. Open Forum Infect Dis. 2022: ofac150, https://doi.org/10.1093/ofid/ofac150
  • Diro E, Corcorran MA, Lan K, Gupta A, Kim HN. Adherence to chronic hepatitis B screening guidelines for persons from intermediate to high prevalence Countries. J Community Health. 2022 May 19. doi: 10.1007/s10900-022-01102-7. Epub ahead of print. PMID: 35587329.
  • Yang WT, Dombrowski JC, Glick SN, Kim HN, Beieler AM, Lan KF, Dhanireddy S. Partial-Oral Antibiotic Therapy for Bone and Joint Infections in People With Recent Injection Drug Use. Open Forum Infect Dis. 2023 Jan 7;10(1):ofad005. doi: 10.1093/ofid/ofad005. PMID: 36726538.
  • Shapiro, AE, Gupta, A, Lan, K, Kim, HN. Latent Tuberculosis Screening Cascade for Non-US-Born Persons in a Large Health System.  Open Forum Infect Dis. 2023;10(7):ofad303. Published 2023 Jun 6. doi:10.1093/ofid/ofad303. PMID: 37426951.
  • Eastment MC, Gupta A, James J, Richardson BA, Pinder L, Kim HN, Wald A, Tsui JI. Cervical cancer screening, abnormal results and follow-up in women with substance use-related diagnosis. Substance Use. 2022;43(1):925-931. doi: 10.1080/08897077.2021.2010257. PMID: 35289732.
  • Sridhar AR, Chatterjee NA, Saour B, Nguyen D, Starnes EA, Johnston C, Green ML, Roth GA, Poole JE. QT interval and arrhythmic safety of hydroxychloroquine monotherapy in coronavirus disease 2019. Heart Rhythm O2. 2020 Aug;1(3):167-172. doi: 10.1016/j.hroo.2020.06.002. PubMed PMID: 32835316.
  • Dobbins NJ, Han B, Zhou W, Lan, KF, Kim, HN, Harrington, R, Uzuner, Ö,  Yetisgen, M. LeafAI: query generator for clinical cohort discovery rivaling a human programmer. J Am Med Inform Assoc. 2023;30(12):1954-1964. doi:10.1093/jamia/ocad149. PMID: 37550244.

Resources & Reading

Date Extraction
Data Management
Quality Improvement
Statistics

Data Requests -ARC data query form

ARC Data Use Agreement and ARC Compensation Policy

Leaf  - Open-source data-driven web application for cohort discovery and translational biomedical research JAMIA article 

Research Data Management Workshop from UW Libraries

Data Management – A Brief "How to" from the UW Virology Research Center

NIH Data Collaboratory on Electronic Health Record Data

RedCap for data collection, surveys and database management

Tutorial for REDCap

UCLA Institute for Digital Research and Education: Stata Data Management

Brief Primer on Quality Improvement

Institute for Healthcare Improvement Whiteboard: Science of Improvement

PCORI Curriculum on Causal Inference methods

Causal Inference when using Observational Data – Lecture by Dr. Amalia Magaret

R for Data Science from R4DS

Intro to R from UW