Dr. Cai has three key areas of research focus:

• The regulatory networks in innate immune response with regard to pattern recognition receptors, transcription factors, and cytokines/chemokines in pulmonary and extra-pulmonary injury and sepsis
• Metabolic regulation of pathogen induced innate immunity response
• The role of mitochondrial dependent signaling in innate immune responses during inflammation and tissue injury

Paudel S, Baral P, Ghimire L, Bergeron S, Jin L, De Corte JA, Le JT, Cai S, Jeyaseelan S.CXCL1 regulates neutrophil homeostasis in pneumonia-derived sepsis caused by Streptococcus pneumoniae serotype 3. Blood. Feb 5, 2019

Ravi Kumar S, Paudel S, Ghimire L, Bergeron S, Cai S, Zemans RL, Downey GP, Jeyaseelan S. Emerging Roles of Inflammasomes in Acute Pneumonia. Am J Respir Crit Care Med. Jan; 197(2):160-171, 2018

Cai S, Batra S, Langohr I, Iwakura Y, Jeyaseelan S. IFN-γ induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense. Mucosal Immunol. May; 9(3):718-29, 2016

Cai S, Batra S, Del Piero F, Jeyaseelan S. NLRP12 modulates host defense through IL-17A-CXCL1 axis. . Mucosal Immunol.  Mar; 9(2):503-14, 2016

Balamayooran G, Batra S,  Theivanthiran B, Cai S, Pacher P, Jeyaseelan  S. Intrapulmonary G-CSF rescues neutrophil recruitment to the lung and neutrophil release to blood in gram-negative bacterial infection in MCP-1-/- mice. J Immunol. Dec 15; 189(12); 5849-59, 2012