Wang Wang, MD, PhD

Associate Professor, Anesthesiology & Pain Medicine

Adjunct Associate Professor of Pathology

Mitochondria and Metabolism Center

Contact

Email: wangwang@uw.edu

Phone: 206-685-4765

Fax: 206-616-4819

About

Mitochondria play a central role in cell bioenergetics, free radical signaling, redox homeostasis, ion regulation, and cell fate determination. Mitochondria dysfunction often accompanies and underlies the pathogenesis of disease. Our lab is interested in elucidating how mitochondrial function, including energy metabolism, reactive oxygen species (ROS) generation, calcium regulation and dynamics, are regulated under pathophysiological conditions. We are also studying whether dysregulation of these mitochondrial functions contributes to cardiovascular and metabolic diseases. In particular, we are using multidisciplinary approaches including novel biomarkers and biosensors, systems biology tools and genetic animal models to determine how metabolism and mitochondrial function participate in heart development and stress-induced heart diseases.

Research

Cardiovascular bioenergetics and mitochondrial biology
Metabolic mechanisms in heart development and physiology
Role of mitochondrial dysfunction in heart disease
Confocal imaging and in vivo evaluation of mitochondrial function

Education

1997

Beijing Medical University, Beijing, China M.D.

2002

Peking University Health Science Center, Beijing, China Ph.D.

Honors & Awards

2018

AHA Established Investigator Award

2015

ADA Gail Patrick Innovation Award

2007

ISHR Richard J. Bing Award for Young Investigators (Finalist)

2004

NIH Fellow Award for Research Excellence

Professional Memberships

AHA, International Society for Heart Research (ISHR)

Selected Publications

Pei Wang, Shangcheng Xu, Jiqian Xu, Yanguo Xin, Yan Lu, Huiliang Zhang, Bo Zhou, Haodong Xu, Shey-Shing Sheu, Rong Tian, Wang Wang. Elevated MCU expression by CaMKIIδB limits pathological cardiac remodeling. Circulation. 145, 1067-1083, 2022.

Qingxun Hu, Dan Wu, Matthew Walker, Pei Wang, Rong Tian, and Wang Wang. Genetically encoded biosensors for evaluating NAD+/NADH ratio in cytosolic and mitochondrial compartments. Cell Reports Methods. 1, 100116, 2021.

Qingxun Hu, Huiliang Zhang, Nicolás Gutiérrez Cortés, Dan Wu, Pei Wang, Jing Zhang, Julie A. Mattison, Eric Smith, Lisa F. Bettcher, Mingyi Wang, Edward G. Lakatta, Shey-Shing Sheu, Wang Wang. Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction. Circ Res. 126, 456-470, 2020.

Wang Wang, Celia Fernandez-Sanz. Shey-Shing Sheu. Regulation of mitochodrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart. Biochim Biophys Acta. 1864, 1991-2001, 2018.

Shangcheng Xu, Pei Wang, Huiliang Zhang, Guohua Gong, Nicolas Gutierrez Cortes, Weizhong Zhu, Yisang Yoon, Rong Tian, Wang Wang. CaMKII induces transient permeability transition through Drp1 phosphorylation during chronic b-AR stimulation. Nat Commun. 7, 13189, 2016.

View Wang Wang's Full Publication List