Dr. Matthew Campbell has been awarded a grant from the NIA to study mitochondrial redox-sensitive signaling and substrate utilization following muscle contraction (K01AG086542). Previous work by Dr. Campbell has shown that improving redox status has a beneficial effect on mitochondrial and muscle function (PMID: 30597195). In a recently published manuscript (PMID: 37742081) Dr. Campbell and the TBL demonstrated that fatty acid and glutamate use following muscle contraction is dependent on age, sex, and intensity of muscle contraction. Using in vivo aged rodent models, and aged three-dimensional engineered muscle tissue Dr. Campbell plans to explore the intersection of redox status, mitochondria and metabolism, and the mitochondrial interactome. For this work he is collaborating with researchers at the UW, Northwest Metabolomics Research Center, and in the Institute for Stem Cell and Regenerative Medicine. This new study will examine the signaling mechanisms related to substrate use following exercise and how those mechanisms change as muscle ages.