Publications

Chiao YA, Zhang H, Sweetwyne M, Whitson J, Ting YS, Basisty N, Pino LK, Quarles E, Nguyen NH, Campbell MD, Zhang T, Gaffrey MJ, Merrihew G, Wang L, Yue Y, Duan D, Granzier HL, Szeto HH, Qian WJ, Marcinek D, MacCoss MJ, Rabinovitch P. Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice. Elife. 2020 Jul 10;9:e55513. doi: 10.7554/eLife.55513. Epub ahead of print. PMID: 32648542.

Chavez JD, Tang X, Campbell MD, Reyes G, Kramer PA, Stuppard R, Keller A, Zhang H, Rabinovitch PS, Marcinek DJ, Bruce JE. Mitochondrial protein interaction landscape of SS-31. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15363-15373. doi: 10.1073/pnas.2002250117. Epub 2020 Jun 17. PMID: 32554501.

Lefebvre KA, Yakes BJ, Frame E, Kendrick P, Shum S, Isoherranen N, Ferriss BE, Robertson A, Hendrix A, Marcinek DJ, Grattan L. Discovery of a Potential Human Serum Biomarker for Chronic Seafood Toxin Exposure Using an SPR Biosensor. Toxins (Basel). 2019 May 23;11(5). pii: E293. doi: 10.3390/toxins11050293. PMID: 31126088. Free PMC Article

Campbell MD, Duan J, Samuelson AT, Gaffrey MJ, Merrihew GE, Egertson JD, Wang L, Bammler TK, Moore RJ, White CC, Kavanagh TJ, Voss JG, Szeto HH, Rabinovitch PS, MacCoss MJ, Qian WJ, Marcinek DJ. Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice. Free Radic Biol Med. 2019 Apr;134:268-281. doi: 10.1016/j.freeradbiomed.2018.12.031. Epub 2018 Dec 28. PMID: 30597195.

Moyer CE, Hiolski EM, Marcinek DJ, Lefebvre KA, Smith DR, Zuo Y. Repeated low level domoic acid exposure increases CA1 VGluT1 levels, but not bouton density, VGluT2 or VGAT levels in the hippocampus of adult mice. Harmful Algae. 2018 Nov;79:74-86. doi: 10.1016/j.hal.2018.08.008. Epub 2018 Sep 5. PMID: 30420019. Free PMC Article

Lefebvre KA, Hendrix A, Halaska B, Duignan P, Shum S, Isoherranen N, Marcinek DJ, Gulland FMD. Domoic acid in California sea lion fetal fluids indicates continuous exposure to a neuroteratogen poses risks to mammals. Harmful Algae. 2018 Nov;79:53-57. doi: 10.1016/j.hal.2018.06.003. Epub 2018 Jul 7. PMID: 30420016.

TOP 10% DOWNLOADED PAPER 2018-2019 Liu SZ, Ali AS, Campbell MD, Kilroy K, Shankland EG, Roshanravan B, Marcinek DJ, Conley KE. Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly. J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):826-833. doi: 10.1002/jcsm.12318. Epub 2018 Sep 26. PMID: 30259703. Free PMC Article

Kramer PA, Duan J, Gaffrey MJ, Shukla AK, Wang L, Bammler TK, Qian WJ, Marcinek DJ. Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. Redox Biol. 2018 Jul;17:367-376. doi: 10.1016/j.redox.2018.05.011. Epub 2018 May 23. PMID: 29857311. Free PMC Article

Yeh A, Marcinek DJ, Meador JP, Gallagher EP. Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon. Aquat Toxicol. 2017 Sep;190:21-31. doi: 10.1016/j.aquatox.2017.06.011. Epub 2017 Jun 16. PMID: 28668760. Free PMC Article

Crouch ML, Knowels G, Stuppard R, Ericson NG, Bielas JH, Marcinek DJ, Syrjala KL. Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects. PLoS One. 2017 Jul 10;12(7):e0181086. doi: 10.1371/journal.pone.0181086. eCollection 2017. PMID: 28700655. Free PMC Article

Moon Y, Balke JE, Madorma D, Siegel MP, Knowels G, Brouckaert P, Buys ES, Marcinek DJ, Percival JM. Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms. Antioxid Redox Signal. 2017 Jun 10;26(17):966-985. doi: 10.1089/ars.2016.6630. Epub 2016 Aug 17. Review. PMID: 27393340.Free PMC Article

Sweetwyne MT, Pippin JW, Eng DG, Hudkins KL, Chiao YA, Campbell MD, Marcinek DJ, Alpers CE, Szeto HH, Rabinovitch PS, Shankland SJ. The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age. Kidney Int. 2017 May;91(5):1126-1145. doi: 10.1016/j.kint.2016.10.036. Epub 2017 Jan 4. PMID: 28063595. Free PMC Article

Lefebvre KA, Kendrick PS, Ladiges W, Hiolski EM, Ferriss BE, Smith DR, Marcinek DJ. Chronic low-level exposure to the common seafood toxin domoic acid causes cognitive deficits in mice. Harmful Algae. 2017 Apr;64:20-29. doi: 10.1016/j.hal.2017.03.003. Epub 2017 Mar 27. PMID: 28427569. Free PMC Article

Ferriss BE, Marcinek DJ, Ayres D, Borchert J, Lefebvre KA. Acute and chronic dietary exposure to domoic acid in recreational harvesters: A survey of shellfish consumption behavior. Environ Int. 2017 Apr;101:70-79. doi: 10.1016/j.envint.2017.01.006. Epub 2017 Jan 18. PMID: 28109640. Free PMC Article

Liu SZ, Marcinek DJ. Skeletal muscle bioenergetics in aging and heart failure. Heart Fail Rev. 2017 Mar;22(2):167-178. doi: 10.1007/s10741-016-9586-z. Review. PMID: 27815651. Free PMC Article

Dai DF, Chiao YA, Martin GM, Marcinek DJ, Basisty N, Quarles EK, Rabinovitch PS. Mitochondrial-Targeted Catalase: Extended Longevity and the Roles in Various Disease Models. Prog Mol Biol Transl Sci. 2017;146:203-241. doi: 10.1016/bs.pmbts.2016.12.015. Epub 2017 Feb 4. Review. PMID: 28253986

Schweppe DK, Chavez JD, Lee CF, Caudal A, Kruse SE, Stuppard R, Marcinek DJ, Shadel GS, Tian R, Bruce JE. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1732-1737. doi: 10.1073/pnas.1617220114. Epub 2017 Jan 27. PMID: 28130547. Free PMC Article

Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med. 2016 Oct 19;8(361):361ra139. PMID: 27798264. Free PMC Article

Campbell MD, Marcinek DJ. Evaluation of in vivo mitochondrial bioenergetics in skeletal muscle using NMR and optical methods. Biochim Biophys Acta. 2016 Apr;1862(4):716-724. doi: 10.1016/j.bbadis.2015.12.019. Epub 2015 Dec 17. Review. PMID: 26708941. Free PMC Article

Kruse SE, Karunadharma PP, Basisty N, Johnson R, Beyer RP, MacCoss MJ, Rabinovitch PS, Marcinek DJ. Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner. Aging Cell. 2016 Feb;15(1):89-99. doi: 10.1111/acel.12412. Epub 2015 Oct 25. PMID: 26498839. Free PMC Article

Wang L, Espinoza HM, MacDonald JW, Bammler TK, Williams CR, Yeh A, Louie KW, Marcinek DJ, Gallagher EP. Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury. Toxicol Sci. 2016 Jan;149(1):145-57. doi: 10.1093/toxsci/kfv223. Epub 2015 Oct 22. PMID: 26494550. Free PMC Article

Kramer PA, Duan J, Qian WJ, Marcinek DJ. The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function. Front Physiol. 2015 Nov 25;6:347. doi: 10.3389/fphys.2015.00347. eCollection 2015. Review. PMID: 26635632. Free PMC Article

Karunadharma PP, Basisty N, Chiao YA, Dai DF, Drake R, Levy N, Koh WJ, Emond MJ, Kruse S, Marcinek D, Maccoss MJ, Rabinovitch PS. Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments. FASEB J. 2015 Aug;29(8):3582-92. doi: 10.1096/fj.15-272666. Epub 2015 May 14. PMID: 25977255. Free PMC Article

Yeh A, Kruse SE, Marcinek DJ, Gallagher EP. Effect of omega-3 fatty acid oxidation products on the cellular and mitochondrial toxicity of BDE 47. Toxicol In Vitro. 2015 Jun;29(4):672-80. doi: 10.1016/j.tiv.2015.01.015. Epub 2015 Feb 7. PMID: 25659769. Free PMC Article

Marcinek DJ, Conley KE. In vivo metabolic spectroscopy identifies deficits in mitochondrial quality and capacity in aging skeletal muscle. Clin Pharmacol Ther. 2014 Dec;96(6):669-71. doi: 10.1038/clpt.2014.179. Epub 2014 Sep 10. No abstract available. PMID: 25207702. Free PMC Article

Hiolski EM, Kendrick PS, Frame ER, Myers MS, Bammler TK, Beyer RP, Farin FM, Wilkerson HW, Smith DR, Marcinek DJ, Lefebvre KA. Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS. Aquat Toxicol. 2014 Oct;155:151-9. doi: 10.1016/j.aquatox.2014.06.006. Epub 2014 Jun 20. PMID: 25033243. Free PMC Article

Dai DF, Chiao YA, Marcinek DJ, Szeto HH, Rabinovitch PS. Mitochondrial oxidative stress in aging and healthspan. Longev Healthspan. 2014 May 1;3:6. doi: 10.1186/2046-2395-3-6. eCollection 2014. Review. PMID: 24860647. Free PMC Article

Marcinek DJ, Siegel MP. Targeting redox biology to reverse mitochondrial dysfunction. Aging (Albany NY). 2013 Aug;5(8):588-9. No abstract available. PMID: 23945201. Free PMC Article

Siegel MP, Kruse SE, Percival JM, Goh J, White CC, Hopkins HC, Kavanagh TJ, Szeto HH, Rabinovitch PS, Marcinek DJ. Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice. Aging Cell. 2013 Oct;12(5):763-71. doi: 10.1111/acel.12102. Epub 2013 Jun 11. PMID: 23692570. Free PMC Article

Conley KE, Amara CE, Bajpeyi S, Costford SR, Murray K, Jubrias SA, Arakaki L, Marcinek DJ, Smith SR. Higher mitochondrial respiration and uncoupling with reduced electron transport chain content in vivo in muscle of sedentary versus active subjects. J Clin Endocrinol Metab. 2013 Jan;98(1):129-36. doi: 10.1210/jc.2012-2967. Epub 2012 Nov 12. PMID: 23150693. Free PMC Article

Percival JM, Siegel MP, Knowels G, Marcinek DJ. Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of Duchenne muscular dystrophy are not alleviated by PDE5 inhibition. Hum Mol Genet. 2013 Jan 1;22(1):153-67. doi: 10.1093/hmg/dds415. Epub 2012 Oct 9. PMID: 23049075. Free PMC Article

Siegel MP, Wilbur T, Mathis M, Shankland EG, Trieu A, Harper ME, Marcinek DJ. Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle. Mech Ageing Dev. 2012 Sep-Oct;133(9-10):620-8. doi: 10.1016/j.mad.2012.08.002. Epub 2012 Aug 19. PMID: 22935551. Free PMC Article

Lefebvre KA, Frame ER, Gulland F, Hansen JD, Kendrick PS, Beyer RP, Bammler TK, Farin FM, Hiolski EM, Smith DR, Marcinek DJ. A novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity. PLoS One. 2012;7(5):e36213. doi: 10.1371/journal.pone.0036213. Epub 2012 May 2. PMID: 22567140. Free PMC Article

Siegel MP, Kruse SE, Knowels G, Salmon A, Beyer R, Xie H, Van Remmen H, Smith SR, Marcinek DJ. Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice. PLoS One. 2011;6(11):e26963. doi: 10.1371/journal.pone.0026963. Epub 2011 Nov 22. PMID: 22132085. Free PMC Article

Dai DF, Johnson SC, Villarin JJ, Chin MT, Nieves-Cintrón M, Chen T, Marcinek DJ, Dorn GW 2nd, Kang YJ, Prolla TA, Santana LF, Rabinovitch PS. Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circ Res. 2011 Apr 1;108(7):837-46. doi: 10.1161/CIRCRESAHA.110.232306. Epub 2011 Feb 10. PMID: 21311045. Free PMC Article

Dai DF, Chen T, Wanagat J, Laflamme M, Marcinek DJ, Emond MJ, Ngo CP, Prolla TA, Rabinovitch PS. Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell. 2010 Aug;9(4):536-44. doi: 10.1111/j.1474-9726.2010.00581.x. Epub 2010 Apr 29. PMID: 20456298. Free PMC Article

Marcinek DJ, Kushmerick MJ, Conley KE. Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle. J Appl Physiol (1985). 2010 Jun;108(6):1479-86. doi: 10.1152/japplphysiol.01189.2009. Epub 2010 Feb 4. PMID: 20133437. Free PMC Article

Lee D, Marcinek D. Noninvasive in vivo small animal MRI and MRS: basic experimental procedures. J Vis Exp. 2009 Oct 20;(32). pii: 1592. doi: 10.3791/1592. PMID: 19844191. Free PMC Article

Amara CE, Marcinek DJ, Shankland EG, Schenkman KA, Arakaki LS, Conley KE. Mitochondrial function in vivo: spectroscopy provides window on cellular energetics. Methods. 2008 Dec;46(4):312-8. doi: 10.1016/j.ymeth.2008.10.001. Epub 2008 Oct 16. PMID: 18930151

Kruse SE, Watt WC, Marcinek DJ, Kapur RP, Schenkman KA, Palmiter RD. Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. Cell Metab. 2008 Apr;7(4):312-20. doi: 10.1016/j.cmet.2008.02.004. PMID: 18396137. Free PMC Article

Conley KE, Marcinek DJ, Villarin J. Mitochondrial dysfunction and age. Curr Opin Clin Nutr Metab Care. 2007 Nov;10(6):688-92. Review. PMID: 18089948

Marcinek DJ, Amara CE, Matz K, Conley KE, Schenkman KA. Wavelength shift analysis: a simple method to determine the contribution of hemoglobin and myoglobin to in vivo optical spectra. Appl Spectrosc. 2007 Jun;61(6):665-9. PMID: 17650380

Conley KE, Jubrias SA, Amara CE, Marcinek DJ. Mitochondrial dysfunction: impact on exercise performance and cellular aging. Exerc Sport Sci Rev. 2007 Apr;35(2):43-9. Review. PMID: 17417049

Amara CE, Shankland EG, Jubrias SA, Marcinek DJ, Kushmerick MJ, Conley KE. Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):1057-62. Epub 2007 Jan 10. PMID: 17215370. Free PMC Article

Conley KE, Amara CE, Jubrias SA, Marcinek DJ. Mitochondrial function, fibre types and ageing: new insights from human muscle in vivo. Exp Physiol. 2007 Mar;92(2):333-9. Epub 2006 Dec 14. Review. PMID: 17170059.

Marcinek DJ, Schenkman KA, Ciesielski WA, Lee D, Conley KE. Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle. J Physiol. 2005 Dec 1;569(Pt 2):467-73. Epub 2005 Oct 27. PMID: 16254011. Free PMC Article

Marcinek DJ. Mitochondrial dysfunction measured in vivo. Acta Physiol Scand. 2004 Dec;182(4):343-52. Review. PMID: 15569095

Marcinek DJ, Schenkman KA, Ciesielski WA, Conley KE. Mitochondrial coupling in vivo in mouse skeletal muscle. Am J Physiol Cell Physiol. 2004 Feb;286(2):C457-63. Epub 2003 Oct 1. PMID: 14522819.

Marcinek DJ, Ciesielski WA, Conley KE, Schenkman KA. Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo. Am J Physiol Heart Circ Physiol. 2003 Nov;285(5):H1900-8. Epub 2003 May 29. PMID: 12775561.

Lambeth MJ, Kushmerick MJ, Marcinek DJ, Conley KE. Basal glycogenolysis in mouse skeletal muscle: in vitro model predicts in vivo fluxes. Mol Biol Rep. 2002;29(1-2):135-9. PMID: 12241044

Marcinek DJ, Bonaventura J, Wittenberg JB, Block BA. Oxygen affinity and amino acid sequence of myoglobins from endothermic and ectothermic fish. Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R1123-33. PMID: 11247835