Marcinek Lab


Lefebvre KA, Yakes BJ, Frame E, Kendrick P, Shum S, Isoherranen N, Ferriss BE, Robertson A, Hendrix A, Marcinek DJ, Grattan L. Discovery of a Potential Human Serum Biomarker for Chronic Seafood Toxin Exposure Using an SPR Biosensor. Toxins (Basel). 2019 May 23;11(5). pii: E293. doi: 10.3390/toxins11050293. PubMed PMID: 31126088.

Campbell MD, Duan J, Samuelson AT, Gaffrey MJ, Wang L, Bammler TK, Moore RJ, White CC, Kavanagh TJ, Voss JG, Szeto HH, Rabinovitch PS, Qian WJ, Marcinek DJ. Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice. Free Radic Biol Med. 2018 Dec 28. pii: S0891-5849(18)32256-1. doi: 10.1016/j.freeradbiomed.2018.12.031. [Epub ahead of print] PubMed PMID: 30597195.

Moyer CE, Hiolski EM, Marcinek DJ, Lefebvre KA, Smith DR, Zuo Y. Repeated low level domoic acid exposure increases CA1 VGluT1 levels, but not bouton density, VGluT2 or VGAT levels in the hippocampus of adult mice. Harmful Algae. 2018 Nov;79:74-86. doi: 10.1016/j.hal.2018.08.008. Epub 2018 Sep 5. PubMed PMID: 30420019; PubMed Central PMCID: PMC6237202.

Lefebvre KA, Hendrix A, Halaska B, Duignan P, Shum S, Isoherranen N, Marcinek DJ, Gulland FMD. Domoic acid in California sea lion fetal fluids indicates continuous exposure to a neuroteratogen poses risks to mammals. Harmful Algae. 2018 Nov;79:53-57. doi: 10.1016/j.hal.2018.06.003. Epub 2018 Jul 7. PubMed PMID: 30420016.

Liu SZ, Ali AS, Campbell MD, Kilroy K, Shankland EG, Roshanravan B, Marcinek DJ, Conley KE. Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly. J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):826-833. doi: 10.1002/jcsm.12318. Epub 2018 Sep 26. PubMed PMID: 30259703; PubMed Central PMCID: PMC6204600.

Kramer PA, Duan J, Gaffrey MJ, Shukla AK, Wang L, Bammler TK, Qian WJ, Marcinek DJ. Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. Redox Biol. 2018 Jul;17:367-376. doi: 10.1016/j.redox.2018.05.011. Epub 2018 May 23. PubMed PMID: 29857311; PubMed Central PMCID: PMC6007084.

Crouch ML, Knowels G, Stuppard R, Ericson NG, Bielas JH, Marcinek DJ, Syrjala KL. Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects. PLoS One. 2017 Jul 10;12(7):e0181086. doi: 10.1371/journal.pone.0181086. eCollection 2017. PubMed PMID: 28700655; PubMed Central PMCID: PMC5507312.

Yeh A, Marcinek DJ, Meador JP, Gallagher EP. Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon. Aquat Toxicol. 2017 Sep;190:21-31. doi: 10.1016/j.aquatox.2017.06.011. PubMed PMID: 28668760; PubMed Central PMCID: PMC5590637.

Lefebvre KA, Kendrick PS, Ladiges W, Hiolski EM, Ferriss BE, Smith DR, Marcinek DJ. Chronic low-level exposure to the common seafood toxin domoic acid causes cognitive deficits in mice. Harmful Algae. 2017 Apr;64:20-29. doi: 10.1016/j.hal.2017.03.003. Epub 2017 Mar 27. PubMed PMID: 28427569; PubMed Central PMCID: PMC5548283.

Dai DF, Chiao YA, Martin GM, Marcinek DJ, Basisty N, Quarles EK, Rabinovitch PS. Mitochondrial-Targeted Catalase: Extended Longevity and the Roles in Various Disease Models. Prog Mol Biol Transl Sci. 2017;146:203-241. doi: 10.1016/bs.pmbts.2016.12.015. PubMed PMID: 28253986.

Schweppe DK, Chavez JD, Lee CF, Caudal A, Kruse SE, Stuppard R, Marcinek DJ, Shadel GS, Tian R, Bruce JE. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1732 1737. doi: 10.1073/pnas.1617220114. PubMed PMID: 28130547; PubMed Central PMCID: PMC5321032.

Ferriss BE, Marcinek DJ, Ayres D, Borchert J, Lefebvre KA. Acute and chronic dietary exposure to domoic acid in recreational harvesters: A survey of shellfish consumption behavior. Environ Int. 2017 Apr;101:70-79. doi:10.1016/j.envint.2017.01.006. PubMed PMID: 28109640; PubMed Central PMCID: PMC5348270.

Sweetwyne MT, Pippin JW, Eng DG, Hudkins KL, Chiao YA, Campbell MD, Marcinek DJ, Alpers CE, Szeto HH, Rabinovitch PS, Shankland SJ. The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age. Kidney Int. 2017 May;91(5):1126-1145. doi: 10.1016/j.kint.2016.10.036. Epub 2017 Jan 4. PubMed PMID: 28063595; PubMed Central PMCID: PMC5392164.

Liu SZ, Marcinek DJ. Skeletal muscle bioenergetics in aging and heart failure. Heart Fail Rev. 2017 Mar;22(2):167-178. doi: 10.1007/s10741-016-9586-z. Review. PubMed PMID: 27815651; PubMed Central PMCID: PMC5352460.

Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med. 2016 Oct 19;8(361):361ra139. PubMed PMID: 27798264; PubMed Central PMCID: PMC5535761.

Moon Y, Balke JE, Madorma D, Siegel MP, Knowels G, Brouckaert P, Buys ES, Marcinek DJ, Percival JM. Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms. Antioxid Redox Signal. 2017 Jun 10;26(17):966-985. doi: 10.1089/ars.2016.6630. Epub 2016 Aug 17. Review. PubMed PMID: 27393340; PubMed Central PMCID: PMC5467110.

Campbell MD, Marcinek DJ. Evaluation of in vivo mitochondrial bioenergetics in skeletal muscle using NMR and optical methods. Biochim Biophys Acta. 2016 Apr;1862(4):716-24. doi: 10.1016/j.bbadis.2015.12.019. Review. PubMed PMID: 26708941; PubMed Central PMCID: PMC4788529.

Kruse SE, Karunadharma PP, Basisty N, Johnson R, Beyer RP, MacCoss MJ, Rabinovitch PS, Marcinek DJ. Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner. Aging Cell. 2016 Feb;15(1):89-99. doi: 10.1111/acel.12412. PubMed PMID: 26498839; PubMed Central PMCID: PMC4717270.

Wang L, Espinoza HM, MacDonald JW, Bammler TK, Williams CR, Yeh A, Louie KW, Marcinek DJ, Gallagher EP. Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury. Toxicol Sci. 2016 Jan;149(1):145-57. doi: 10.1093/toxsci/kfv223. PubMed PMID: 26494550; PubMed Central PMCID: PMC4731405.

Kramer PA, Duan J, Qian WJ, Marcinek DJ. The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function. Front Physiol. 2015 Nov 25;6:347. doi: 10.3389/fphys.2015.00347. Review. PubMed PMID: 26635632; PubMed Central PMCID: PMC4658434.

Yeh A, Kruse SE, Marcinek DJ, Gallagher EP. Effect of omega-3 fatty acid oxidation products on the cellular and mitochondrial toxicity of BDE 47. Toxicol In Vitro. 2015 Jun;29(4):672-80. doi: 10.1016/j.tiv.2015.01.015. PubMed PMID: 25659769; PubMed Central PMCID: PMC4479582.

Marcinek DJ, Conley KE. In vivo metabolic spectroscopy identifies deficits in mitochondrial quality and capacity in aging skeletal muscle. Clin Pharmacol Ther. 2014 Dec;96(6):669-71. doi: 10.1038/clpt.2014.179. PubMed PMID: 25207702; PubMed Central PMCID: PMC4707046.

Hiolski EM, Kendrick PS, Frame ER, Myers MS, Bammler TK, Beyer RP, Farin FM, Wilkerson HW, Smith DR, Marcinek DJ, Lefebvre KA. Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS. Aquat Toxicol. 2014 Oct;155:151-9. doi: 10.1016/j.aquatox.2014.06.006. Epub 2014  Jun 20. PubMed PMID: 25033243; PubMed Central PMCID: PMC4139102.

Dai DF, Chiao YA, Marcinek DJ, Szeto HH, Rabinovitch PS. Mitochondrial oxidative stress in aging and healthspan. Longev Healthspan. 2014 May 1;3:6. doi: 10.1186/2046-2395-3-6. eCollection 2014. Review. PubMed PMID: 24860647; PubMed Central PMCID: PMC4013820.

Marcinek DJ, Siegel MP. Targeting redox biology to reverse mitochondrial dysfunction. Aging (Albany NY). 2013 Aug;5(8):588-9. PubMed PMID: 23945201; PubMed Central PMCID: PMC3796210.

Siegel MP, Kruse SE, Percival JM, Goh J, White CC, Hopkins HC, Kavanagh TJ, Szeto HH, Rabinovitch PS, Marcinek DJ. Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice. Aging Cell. 2013 Oct;12(5):763-71. doi: 10.1111/acel.12102. Epub 2013 Jun 11. PubMed PMID: 23692570; PubMed Central PMCID: PMC3772966.

Conley KE, Amara CE, Bajpeyi S, Costford SR, Murray K, Jubrias SA, Arakaki L, Marcinek DJ, Smith SR. Higher mitochondrial respiration and uncoupling with reduced electron transport chain content in vivo in muscle of sedentary versus active subjects. J Clin Endocrinol Metab. 2013 Jan;98(1):129-36. doi: 10.1210/jc.2012-2967. Epub 2012 Nov 12. PubMed PMID: 23150693; PubMed Central PMCID: PMC3537085.

Percival JM, Siegel MP, Knowels G, Marcinek DJ. Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of Duchenne muscular dystrophy are not alleviated by PDE5 inhibition. Hum Mol Genet. 2013 Jan 1;22(1):153-67. doi: 10.1093/hmg/dds415. Epub 2012 Oct 9. PubMed PMID: 23049075; PubMed Central PMCID: PMC3522404.

Siegel MP, Wilbur T, Mathis M, Shankland EG, Trieu A, Harper ME, Marcinek DJ. Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle. Mech Ageing Dev. 2012 Sep-Oct;133(9-10):620-8. doi: 10.1016/j.mad.2012.08.002. Epub 2012 Aug 19. PubMed PMID: 22935551; PubMed Central PMCID: PMC3456966.

Lefebvre KA, Frame ER, Gulland F, Hansen JD, Kendrick PS, Beyer RP, Bammler TK, Farin FM, Hiolski EM, Smith DR, Marcinek DJ. A novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity. PLoS One. 2012;7(5):e36213. doi: 10.1371/journal.pone.0036213. Epub 2012 May 2. PubMed PMID: 22567140; PubMed Central PMCID: PMC3342169.

Siegel MP, Kruse SE, Knowels G, Salmon A, Beyer R, Xie H, Van Remmen H, Smith SR, Marcinek DJ. Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice. PLoS One. 2011;6(11):e26963. doi: 10.1371/journal.pone.0026963. Epub 2011 Nov 22. PubMed PMID: 22132085; PubMed Central PMCID: PMC3222658.

Dai DF, Johnson SC, Villarin JJ, Chin MT, Nieves-Cintrón M, Chen T, Marcinek DJ, Dorn GW 2nd, Kang YJ, Prolla TA, Santana LF, Rabinovitch PS. Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circ Res. 2011 Apr 1;108(7):837-46. doi: 10.1161/CIRCRESAHA.110.232306. Epub 2011 Feb 10. PubMed PMID: 21311045; PubMed Central PMCID: PMC3785241.

Dai DF, Chen T, Wanagat J, Laflamme M, Marcinek DJ, Emond MJ, Ngo CP, Prolla TA, Rabinovitch PS. Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell. 2010 Aug;9(4):536-44. doi: 10.1111/j.1474-9726.2010.00581.x. Epub 2010 Apr 29. PubMed PMID: 20456298; PubMed Central PMCID: PMC3265170.

Marcinek DJ, Kushmerick MJ, Conley KE. Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle. J Appl Physiol (1985). 2010 Jun;108(6):1479-86. doi: 10.1152/japplphysiol.01189.2009. Epub 2010 Feb 4. PubMed PMID: 20133437; PubMed Central PMCID: PMC2886682.

Lee D, Marcinek D. Noninvasive in vivo small animal MRI and MRS: basic experimental procedures. J Vis Exp. 2009 Oct 20;(32). pii: 1592. doi: 10.3791/1592. PubMed PMID: 19844191; PubMed Central PMCID: PMC2865975.

Amara CE, Marcinek DJ, Shankland EG, Schenkman KA, Arakaki LS, Conley KE. Mitochondrial function in vivo: spectroscopy provides window on cellular energetics. Methods. 2008 Dec;46(4):312-8. doi: 10.1016/j.ymeth.2008.10.001. Epub 2008 Oct 16. PubMed PMID: 18930151.

Kruse SE, Watt WC, Marcinek DJ, Kapur RP, Schenkman KA, Palmiter RD. Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. Cell Metab. 2008 Apr;7(4):312-20. doi: 10.1016/j.cmet.2008.02.004. PubMed PMID: 18396137; PubMed Central PMCID: PMC2593686.

Conley KE, Marcinek DJ, Villarin J. Mitochondrial dysfunction and age. Curr Opin Clin Nutr Metab Care. 2007 Nov;10(6):688-92. Review. PubMed PMID: 18089948.

Marcinek DJ, Amara CE, Matz K, Conley KE, Schenkman KA. Wavelength shift analysis: a simple method to determine the contribution of hemoglobin and myoglobin to in vivo optical spectra. Appl Spectrosc. 2007 Jun;61(6):665-9. PubMed PMID: 17650380.

Conley KE, Jubrias SA, Amara CE, Marcinek DJ. Mitochondrial dysfunction: impact on exercise performance and cellular aging. Exerc Sport Sci Rev. 2007 Apr;35(2):43-9. Review. PubMed PMID: 17417049.

Amara CE, Shankland EG, Jubrias SA, Marcinek DJ, Kushmerick MJ, Conley KE. Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):1057-62. Epub 2007 Jan 10. PubMed PMID: 17215370; PubMed Central PMCID: PMC1766336.

Conley KE, Amara CE, Jubrias SA, Marcinek DJ. Mitochondrial function, fibre types and ageing: new insights from human muscle in vivo. Exp Physiol. 2007 Mar;92(2):333-9. Epub 2006 Dec 14. Review. PubMed PMID: 17170059.

Marcinek DJ, Schenkman KA, Ciesielski WA, Lee D, Conley KE. Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle. J Physiol. 2005 Dec 1;569(Pt 2):467-73. Epub 2005 Oct 27. PubMed PMID: 16254011; PubMed Central PMCID: PMC1464247.

Marcinek DJ. Mitochondrial dysfunction measured in vivo.Acta Physiol Scand. 2004 Dec;182(4):343-52. Review. PubMed PMID: 15569095.

Marcinek DJ, Schenkman KA, Ciesielski WA, Conley KE. Mitochondrial coupling in vivo in mouse skeletal muscle. Am J Physiol Cell Physiol. 2004 Feb;286(2):C457-63. Epub 2003 Oct 1. PubMed PMID: 14522819.

Marcinek DJ, Ciesielski WA, Conley KE, Schenkman KA. Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo. Am J Physiol Heart Circ Physiol. 2003 Nov;285(5):H1900-8. Epub 2003 May 29. PubMed PMID: 12775561.

Lambeth MJ, Kushmerick MJ, Marcinek DJ, Conley KE. Basal glycogenolysis in mouse skeletal muscle: in vitro model predicts in vivo fluxes. Mol Biol Rep. 2002;29(1-2):135-9. PubMed PMID: 12241044.

Marcinek DJ, Bonaventura J, Wittenberg JB, Block BA. Oxygen affinity and amino acid sequence of myoglobins from endothermic and ectothermic fish. Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R1123-33. PubMed PMID: 11247835.