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The Tian Laboratory focuses on the roles of cell metabolism and mitochondrial function in the pathogenesis of human diseases. We take multidisciplinary approaches to engineer and interrogate the metabolic network in both cellular and animal models. Our ability to target molecular regulatory mechanisms in combination of rigorous metabolic phenotyping has led to groundbreaking discoveries in cardiometabolic research. The current research includes four main areas: energy metabolism of the heart, mitochondrial biology, stem cell metabolism, and immunometabolism. Dr. Tian is also interested in bi-directional translational research between the bench and the bedside to elucidate disease mechanisms and to develop novel therapies.