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Shanshan Cai, PhD

Research Assistant Professor of Anesthesiology & Pain Medicine

Research Interests

Dr. Cai has three key areas of research focus:

  • The regulatory networks in innate immune response with regard to pattern recognition receptors, transcription factors, and cytokines/chemokines in pulmonary and extra-pulmonary injury and sepsis

  • Metabolic regulation of pathogen induced innate immunity response

  • The role of mitochondrial dependent signaling in innate immune responses during inflammation and tissue injury

Honors and Awards

2012 – 2017      Flight Attendant Medical Research Institute (FAMRI)-YCSA (Young Clinical Scientist Award)
2014 – 2015      SVM Competitive Research Program (CORP) Award.


Member, American Thoracic Society
Member, American Association of Immunologists

Current Funding

National Institutes of Health (R01): Innate Immunity in Pneumonic Sepsis


  • Paudel S, Baral P, Ghimire L, Bergeron S, Jin L, De Corte JA, Le JT, Cai S, Jeyaseelan S.CXCL1 regulates neutrophil homeostasis in pneumonia-derived sepsis caused by Streptococcus pneumoniae serotype 3. Blood. Feb 5, 2019
  • Ravi Kumar S, Paudel S, Ghimire L, Bergeron S, Cai S, Zemans RL, Downey GP, Jeyaseelan S. Emerging Roles of Inflammasomes in Acute Pneumonia. Am J Respir Crit Care Med. Jan; 197(2):160-171, 2018
  • Cai S, Batra S, Langohr I, Iwakura Y, Jeyaseelan S. IFN-γ induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense. Mucosal Immunol. May; 9(3):718-29, 2016
  • Cai S, Batra S, Del Piero F, Jeyaseelan S. NLRP12 modulates host defense through IL-17A-CXCL1 axis. . Mucosal Immunol.  Mar; 9(2):503-14, 2016
  • Balamayooran G, Batra S,  Theivanthiran B, Cai S, Pacher P, Jeyaseelan  S. Intrapulmonary G-CSF rescues neutrophil recruitment to the lung and neutrophil release to blood in gram-negative bacterial infection in MCP-1-/- mice. J Immunol. Dec 15; 189(12); 5849-59, 2012
  • Cai SBatra SWakamatsu NPacher PJeyaseelan S. NLRC4 Inflammasome-Mediated Production of IL-1β Modulates Mucosal Immunity in the Lung against Gram-Negative Bacterial Infection. J Immunol.  Jun 1; 188(11):5623-35, 2012
  • Batra SCai SBalamayooran GJeyaseelan S. Intrapulmonary Administration of Leukotriene B4 Augments Neutrophil Accumulation and Responses in the Lung to Klebsiella Infection in CXCL1 Knockout Mice. J Immunol.  Apr 1; 188(7):3458-68, 2012
  • Balamayooran GBatra SCai SMei JWorthen GSPenn ALJeyaseelan S. Role of CXCL5 in Leukocyte Recruitment to the Lungs During Secondhand Smoke Exposure. Am J Respir Cell Mol Biol.   Jul; 47(1):104-11, 2012
  • Cai S, Batra S, Lira SA, Kolls JK, Jeyaseelan S. CXCL1 Regulates Pulmonary Host Defense to Klebsiella Infection via CXCL2, CXCL5, NF-{kappa}B, and MAPKs. The Journal of Immunology. 185: 6214-6225, 2010
  • Cai S, Batra,S Shen L, Wakamatsu N, and Jeyaseelan Both TRIF- and MyD88-Dependent Signaling Contribute to Host Defense against Pulmonary Klebsiella Infection. The Journal of Immunology, 183: 6629 -6638, 2009
  •  Cai S, Zemans RL, Young SK, Uematsu S, Akira S, Worthen S and Jeyaseelan S. MD-2-dependent and independent Neutrophil accumulation during Escherichia coli pneumonia. American Journal of Respiratory Cell and Molecular Biology, 40:701-709, 2009
  •  Craig A, Mai J, Cai S, Jeyaseelan S. Neutrophil Recruitment to the Lungs during Bacterial Pneumonia. Infection and Immunity, 77: 568-575, 2009
  •  Cai S, Shimizu T and Tomioka H, Comparative studies on the roles of the mediator molecules in expression of the suppressor activity of Mycobacterium avium complex-induced immunosuppressive macrophages against T cell and B cell mitogenic responses. Clinical and Experimental Immunology. 143:560-571, 2006
  •  Cai S, Sato K, Shimizu T, Yamabe S, Hiraki M, Sani C, Tomioka H. Antimicrobial activity of picolinic acid against extracellular and intracellular Mycobacterium avium complex and its combined activity with clarithromycin, rifampicin and fluoroquinolones. Journal Antimicrobial Chemotherapy, 57:85-93, 2006

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