Glucose promotes cell growth by suppressing branched-chain amino acid degradation.

Shao D, Villet O, Zhang Z, Choi SW, Yan J, Ritterhoff J, Gu H, Djukovic D, Christodoulou D, Kolwicz SC Jr, Raftery D, Tian R. 2018 Jul 26;9(1):2935. doi: 10.1038/s41467-018-05362-7. PMID: 30050148

NAD(H) in mitochondrial energy transduction: implications for health and disease.

Walker MA, Tian R. 2018; 3:101-109. https://doi.org/10.1016/j.cophys.2018.03.011

Raising NAD in Heart Failure: Time to Translate?

Walker MA, Tian R. 2018 May 22;137(21):2274-2277. doi: 10.1161/CIRCULATIONAHA.117.032626. PMID:29784680

The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function.

Roe ND, Handzlik MK, Li T, Tian R. 2018 Mar 21;8(1):4983. doi: 10.1038/s41598-018-23223-7. PMID: 29563512

Failed power plant turns into mass murder: New insight on mitochondrial cardiomyopathy.

Lee CF, Cao Y, Tian R. 2018 Jan 5;122(1):11-­13. doi: 10.1161/CIRCRESAHA.117.312288. PMID:29301837


An open-­label, non-­randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers.

Airhart SE, Shireman LM, Risler LJ, Anderson GD, Nagana Gowda GA, Raftery D, Tian R, Shen DD, O’Brien KD. 2017 Dec 6;12(12): e0186459. doi: 10.1371/journal.pone.0186459. eCollection 2017. PMID:29211728

Cross-­linking and mass spectrometry: taking systems structural biology to heart.

Chavez JD, Lee CF, Caudal A, Tian R, Bruce JE. 2017 Nov 24. pii: S2405-­4712(17)30487-­8. doi: 10.1016/j.cels.2017.10.017. [Epub ahead of print] PMID: 29199018

Activation of γ2-­AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury.

Cao Y, Bojjireddy N, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD, Tian R. 2017 Aug 23. pii: CIRCRESAHA.117.311159. doi: 10.1161/CIRCRESAHA.117.311159. [Epub ahead of print] PMID:28835357

The Effects of Fatty Acid Composition on Cardiac Hypertrophy and Function in Mouse Models of Diet-­Induced Obesity.

Nguyen S, Shao D, Tomasi LC, Braun A, de Mattos ABM, Choi YS, Villet O, Roe N, Halterman CR, Tian R, Kolwicz SC. 2017 Aug; 46:137-­142. doi: 10.1016/j.jnutbio.2017.05.009. Epub 2017 May 25. PMID: 28605665

Metabolism in cardiomyopathy: every substrate matters.

Ritterhoff J, Tian R. 2017 Mar 15; 113(4):411-­421. doi: 10.1093/cvr/cvx017. PMID: 28395011

Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes

Dai DF, Danoviz ME, Wiczer B, Laflamme MA,Tian R. 2017, 2017:5153625. doi: 10.1155/2017/5153625. Epub 2017 Feb 27. PMID: 28421116

Mitochondrial protein interactome elucidated by chemical cross-­linking mass spectrometry.

Schweppe DK, Chavez JD, Lee CF, Caudal A, Kruse SE, Stuppard R, Marcinek DJ, Shadel GS, Tian R, Bruce JE.2017 Feb 14;;114(7):1732-­1737. doi: 10.1073/pnas.1617220114. PMID: 28130547

Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury.

Li T, Zhang Z, Kolwicz Jr. SC, Abell L, Roe ND, Kim M, Zhou B, Cao Y, Ritterhoff J, Gu H, Raftery D, Sun H, Tian R. 2017 Feb 7; PMID: 28178567


Novel targets for mitochondrial medicine.

Wang W, Karamanlidis G, Tian R. Sci Transl Med. 2016 Feb 17; 8(326):326rv3

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts.

Chiao YA, Kolwicz SC, Basisty N, Gagnidze A, Zhang J, Gu H, Djukovic D, Beyer RP, Raftery D, MacCoss M, et. al. Aging (Albany NY). 2016 Feb 11;

The Relationship Between KLF5 and PPARα in the Heart: It’s Complicated.

Roe ND, Standage SW, Tian R. Circ Res. 2016 Jan 22;118(2):193-5. doi:10.1161/CIRCRESAHA.115.308069. PubMed PMID: 26838311; PubMed Central PMCID:PMC4743553.

Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure?

Kolwicz SC Jr, Airhart S, Tian R.  Circulation. 2016 Jan 27. pii: CIRCULATIONAHA.116.021230. [Epub ahead of print] PubMed PMID: 26819375.


Mitochondrion as a Target for Heart Failure Therapy- Role of Protein Lysine Acetylation.

Lee CF, Tian R. Circ J. 2015;79(9):1863-70. doi:10.1253/circj.CJ-15-0742. Epub 2015 Aug 4. PubMed PMID: 26248514.

Glucose Transporters in Cardiac Metabolism and Hypertrophy.

Shao D, Tian R. Compr Physiol. 2015 Dec 15;6(1):331-51. doi: 10.1002/cphy.c150016. PubMed PMID:26756635.

Revealing Pathway Dynamics in Heart Diseases by Analyzing Multiple Differential Networks.

Ma X, Gao L, Karamanlidis G, Gao P, Lee CF, Garcia-Menendez L, Tian R, Tan K. PLoS Comput Biol. 2015 Jun 17;11(6):e1004332. doi: 10.1371/journal.pcbi.1004332. eCollection 2015 Jun.

Enhancing Cardiac Triacylglycerol Metabolism Improves Recovery From Ischemic Stress.

Kolwicz SC Jr, Liu L, Goldberg IJ, Tian R. Diabetes. 2015 Aug;64(8):2817-27. doi: 10.2337/db14-1943. Epub 2015 Apr 9.


Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death.

Nabben M, van Bree BW, Lenaers E, Hoeks J, Hesselink MK, Schaart G, Gijbels MJ, Glatz JF, da Silva GJ, de Windt LJ, Tian R, Mike E, Skapura DG, Wehrens XH, Schrauwen P.  Basic Res Cardiol. 2014 Nov;109(6):447. doi: 10.1007/s00395-014-0447-4. Epub 2014 Oct 25.

Karamanlidis G, Garcia Menendez L, Kolwicz SC Jr, Lee CF, Tian R. Promoting PGC1α-driven Mitochondrial Biogenesis Is Detrimental In Pressure Overloaded Mouse Hearts. Am J Physiol Heart Circ Physiol. 2014 Aug 29. pii: ajpheart.00280.2014. [Epub ahead of print] PMID: 25172896

Kim M, Hunter RW, Garcia-Menendez L, Gong G, Yang YY, Kolwicz SC Jr, Xu J, Wang W, Sakamoto K, Tian R. Mutation in the γ2-subunit of AMPK Stimulates Cardiomyocyte Proliferation and Hypertrophy Independent of Glycogen Storage. Circ Res. 2014 Mar 14;114(6):966-75. Epub 2014 Feb 6.

Yu Q, Lee CF, Wang W, Karamanlidis G, Kuroda J, Matsushima S, Sadoshima J, Tian R. Elimination of NADPH oxidase activity promotes reductive stress and sensitizes the heart to ischemic injury. J Am Heart Assoc. 2014 Jan 27;3(1):e000555. doi: 10.1161/JAHA.113.000555.


Khan RS, Lin Y, Hu Y, Son NH, Bharadwaj KG, Palacios C, Chokshi A, Ji R, Yu S, Homma S, Schulze PC, Tian R, Goldberg IJ. Rescue of heart lipoprotein lipase-knockout mice confirms a role for triglyceride in optimal heart metabolism and function. Am J Physiol Endocrinol Metab. 2013 Dec;305(11):E1339-47.

Dai DF, Hsieh EJ, Chen T, Menendez LG, Basisty NB, Tsai L, Beyer RP, Crispin DA, Shulman NJ, Szeto HH, Tian R, Maccoss MJ, Rabinovitch PS. Global Proteomics and Pathway Analysis of Pressure-overload Induced Heart Failure and Its Attenuation by Mitochondrial Targeted Peptides. Circ Heart Fail. 2013 Sep 1;6(5):1067-76. Epub 2013 Aug 9. PMID: 23935006

Kolwicz Jr. SC, Purohit S, Tian R. Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes. Circ Res. 2013 Aug 16;113(5):603-16.

Karamanlidis, G., Lee, C.F., Garcia-Menendez, L., Kolwicz Jr., S.C., Suthammarak, W., Gong, G., Sedensky, M.M., Morgan, P.G., Wang, W., Tian, R. Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure. Cell Metabolism, 2013.

Garcia-Menendez, L., Karamanlidis, G., Kolwicz, S.C., Tian, R. (May 24 2013) Substrain specific response to cardiac pressure overload in C57BL/6 mice. American Journal of Physiology, 2013 May 24.

Nowakowski, S.G., Kolwicz, S.C., Korte, F.S., Luo, Z., Robinson-Hamm, J.N., Page, J.L., Brozovich, F., Weiss, R.S., Tian, R., Murry, C.E., Regnier, M. Transgenic overexpression of ribonucleotide reductase improves cardiac performance. Proc. Natl. Acad. Sci. USA., 2013 Mar 25.

Matsushima, S., Kuroda, J., Ago, T., Zhai, P., Ikeda, Y., Oka, S., Fong, G.H., Tian, R., Sadoshima, J., Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of HIF-1 and Upregulation of PPARα. Circular Research, 2013 Mar 8.

Marney, L.C., Kolwicz, Jr., S.C., Tian, R., Synovec, R.E. Sample preparation methodology for mouse heart metabolomics using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry. Talanta, 2013,108:123–130.


Kim, M., Tian, R. Transcript Variants dictate PRKAG2 cardiomyopathy? J. Mol. Cell. Cardiol,, 2012, Oct; 51(4):548-53. PMID: 21147121.

Kolwicz, Jr., S.C., Olson, D.P., Marney, L.C., Garcia-Menendez, L. Synovec R.E., Tian, R. Cardiac-specific deletion of acetyl CoA carboxylase 2 (ACC2) prevents metabolic remodeling during pressure-overload hypertrophy. Circ. Res., 2012, Aug 31; 111(6): 728-38. PMID: 22730442.

Kim, M,, Shen, M., Ngoy, S., Karamanlidis, G., Liao, R., Tian, R., AMPK Isoform expression in the normal and failing hearts. J. Mol. Cell. Cardiol., 2012 May;52(5):1066-73. Epub 2012 Jan 31. PMID: 22314372.

Yoshioka, J., Chutkow, W.A., Lee, S., Kim, J.B., Yan, J., Tian, R., Lindsey, M.L., Feener, E.P., Seidman, C.E., Seidman, J.G., Lee, R.T. Deletion of Thioredoxin-Interacting Protein Impairs Mitochondrial Function but Protects the Myocardium from Ischemia-Reperfusion Injury. J. Clin. Invest., 2012 Jan 3; 122(1):267-79. Epub 2011 Dec 27. PMID: 22201682.


Karamanlidis, G., Bautista-Hernandez, V., Fynn-Thompson, F., Del Nido, P., Tian, R. Impaired Mitochondrial Biogenesis Precedes Heart Failure in Right Ventricular Hypertrophy in Congenital Heart Disease. Circ. Heart Fail., 2011 Nov 1; 4 (6): 707-13. Epub 2011 Aug 12 PMID: 21840936.

Dzeja, P.P., Hoyer, K., Tian, R., Zhang, S., Nemutlu, E., Spindler, M., Ingwall, J.S. Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency. J. Physiol., 2011 Nov 1; 589 (Pt 21): 5193-211 Epub 2011 Aug 30. PMID: 21878522.

Pinz, I., Tian, R., Belke, D., Swanson, E., Dillmann, W., Ingwall, J.S. Compromised myocardial energetics in hypertrophied mouse hearts diminish the beneficial effect of overexpressing SERCA2a. J. Biol. Chem., 2011 Mar 25; 286(12):10163-8. Epub 2011 Jan 29. PMID: 21278384 PMCID: PMC3060468.

Xie, Z., Lau, K., Eby, B., Lozano, P., He, C., Pennington, B., Li, H., Rathi, S., Dong, Y., Tian, R., Kem, D., Zou, M.H. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes, 2011 Jun; 60(6):1770-8. Epub 2011 May 11. PMID: 21562078 PMCID: PMC3114402.

Kolwicz Jr., S.C., Tian, R. Glucose metabolism and cardiac hypertrophy. Cardiovasc. Res., 2011 May 1; 90(2):194-201. PMID:21502371 [PubMed- in process].

Kim, M., Tian, R.Targeting AMPK for cardiac protection: Opportunities and Challenges. J. Mol. Cell. Cardiol., 2011 Oct; 5 (4): 548-53. Epub 2010 Dec 13 PMID:21147121.

Kolwicz Jr., S.C., Tian, R. Assessment of cardiac function and energetics in isolated mouse hearts using 31P NMR spectroscopy. J. Vis. Exp., 2010 Aug 31;(42). pii: 2069. doi: 10.3791/2069. PMID: 20834220.

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