2024
Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review. Wiley AM, Yang J, Madhani R, Nath A, Totah RA. Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review. Drug Metab Rev. 2024 Mar 20:1-19. doi: 10.1080/03602532.2024.2329928. Epub ahead of print. PMID: 38478383.
2023
CYP2D6 activity is correlated with changes in plasma concentrations of taurocholic acid during pregnancy and postpartum in CYP2D6 extensive metabolizers. Czuba LC, Malhotra K, Enthoven L, Fay EE, Moreni SL, Mao J, Shi Y, Huang W, Totah RA, Isoherranen N, Hebert MF. CYP2D6 activity is correlated with changes in plasma concentrations of taurocholic acid during pregnancy and postpartum in CYP2D6 extensive metabolizers. Drug Metab Dispos. 2023 Aug 7:DMD-AR-2023-001358. doi: 10.1124/dmd.123.001358. Epub ahead of print. PMID: 37550070.
METTL7A (TMT1A) and METTL7B (TMT1B) are responsible for alkyl S-thiol methyl transferase activity in liver. Russell DA, Chau MK, Shi Y, Levasseur IN, Maldonato BJ, Totah RA. METTL7A (TMT1A) and METTL7B (TMT1B) Are Responsible for Alkyl S-Thiol Methyl Transferase Activity in Liver. Drug Metab Dispos. 2023 Aug;51(8):1024-1034. doi: 10.1124/dmd.123.001268. Epub 2023 May 3. PMID: 37137720; PMCID: PMC10353073.
Plasma hydrogen sulfide, nitric oxide, and thiocyanate levels are lower during pregnancy compared to postpartum in a cohort of women from the Pacific northwest of the United States. Zeigler MB, Fay EE, Moreni SL, Mao J, Totah RA, Hebert MF. Plasma hydrogen sulfide, nitric oxide, and thiocyanate levels are lower during pregnancy compared to postpartum in a cohort of women from the Pacific northwest of the United States. Life Sci. 2023 Jun 1;322:121625. doi: 10.1016/j.lfs.2023.121625. Epub 2023 Mar 30. PMID: 37001802; PMCID: PMC10133030.
Cardioprotective mechanisms of cytochrome P450 derived oxylipins from ω-3 and ω-6 PUFAs. Cho C, Aliwarga T, Wiley AM, Totah RA. Cardioprotective mechanisms of cytochrome P450 derived oxylipins from ω-3 and ω-6 PUFAs. Adv Pharmacol. 2023;97:201-227. doi: 10.1016/bs.apha.2023.02.001. Epub 2023 Mar 27. PMID: 37236759.
The Effects of Pregnancy on Amino Acid Levels and Nitrogen Disposition. Enthoven LF, Shi Y, Fay EE, Moreni S, Mao J, Honeyman EM, Smith CK, Whittington D, Brockerhoff SE, Isoherranen N, Totah RA, Hebert MF. The Effects of Pregnancy on Amino Acid Levels and Nitrogen Disposition. Metabolites. 2023 Feb 7;13(2):242. doi: 10.3390/metabo13020242. PMID: 36837861; PMCID: PMC9961409.
2022
Future of Biotransformation Science in the Pharmaceutical Industry. Kramlinger VM, Dalvie D, Heck CJS, Kalgutkar AS, O’Neill J, Su D, Teitelbaum AM, Totah RA. Future of Biotransformation Science in the Pharmaceutical Industry. Drug Metab Dispos. 2022 Mar;50(3):258-267. doi: 10.1124/dmd.121.000658. Epub 2021 Dec 17. PMID: 34921097.
Selective deuteration of bupropion slows epimerization and reduces metabolism. Shi Y, Dinh J, Pelletier R, Raccor B, Yusuff N, Morgan AJ, Harbeson S, Uttamsingh V, Totah RA. Selective deuteration of bupropion slows epimerization and reduces metabolism. Bioorg Med Chem Lett. 2022 Nov 15;76:129009. doi: 10.1016/j.bmcl.2022.129009. Epub 2022 Sep 27. PMID: 36174836.
Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation. Aliwarga T, Dinh JC, Heyward S, Prasad B, Gharib SA, Lemaitre RN, Sotoodehnia N, Totah RA. Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation. Int J Mol Sci. 2022 Oct 17;23(20):12433. doi: 10.3390/ijms232012433. PMID: 36293289; PMCID: PMC9604309.
Plasma epoxyeicosatrienoic acids and diabetes-related cardiovascular disease: The cardiovascular health study. Lemaitre RN, Jensen PN, Zeigler M, Fretts AM, Umans JG, Howard BV, Sitlani CM, McKnight B, Gharib SA, King IB, Siscovick DS, Psaty BM, Sotoodehnia N, Totah RA. Plasma epoxyeicosatrienoic acids and diabetes-related cardiovascular disease: The cardiovascular health study. EBioMedicine. 2022 Sep;83:104189. doi: 10.1016/j.ebiom.2022.104189. Epub 2022 Aug 2. PMID: 35930887; PMCID: PMC9356248.
Reductions in Hydrogen Sulfide and Changes in Mitochondrial Quality Control Proteins Are Evident in the Early Phases of the Corneally Kindled Mouse Model of Epilepsy. Cho C, Zeigler M, Mizuno S, Morrison RS, Totah RA, Barker-Haliski M. Reductions in Hydrogen Sulfide and Changes in Mitochondrial Quality Control Proteins Are Evident in the Early Phases of the Corneally Kindled Mouse Model of Epilepsy. Int J Mol Sci. 2022 Jan 27;23(3):1434. doi: 10.3390/ijms23031434. PMID: 35163358; PMCID: PMC8835945.
2021
Plasma epoxyeicosatrienoic acids and dihydroxyeicosatrieonic acids, insulin, glucose and risk of diabetes: The strong heart study. EBioMedicine. 2021 Apr;66:103279. doi: 10.1016/j.ebiom.2021.103279. Epub 2021 Mar 19.PMID: 33752126
Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril. Maldonato BJ, Russell DA, Totah RA. Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril. Sci Rep. 2021 Mar 1;11(1):4857. doi: 10.1038/s41598-021-84218-5. PMID: 33649426; PMCID: PMC7921093.
Changes in erythrocyte membrane epoxyeicosatrienoic, dihydroxyeicosatrienoic, and hydroxyeicosatetraenoic acids during pregnancy. Somani ST, Zeigler M, Fay EE, Leahy M, Bermudez B, Totah RA, Hebert MF. Changes in erythrocyte membrane epoxyeicosatrienoic, dihydroxyeicosatrienoic, and hydroxyeicosatetraenoic acids during pregnancy. Life Sci. 2021 Jan 1;264:118590. doi: 10.1016/j.lfs.2020.118590. Epub 2020 Oct 15. PMID: 33069736; PMCID: PMC7755749.
Sources of Interindividual Variability. Lin YS, Thummel KE, Thompson BD, Totah RA, Cho CW. Sources of Interindividual Variability. Methods Mol Biol. 2021;2342:481-550. doi: 10.1007/978-1-0716-1554-6_17. PMID: 34272705.
2020
Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors. Evangelista EA, Cho CW, Aliwarga T, Totah RA. Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors. Front Pharmacol. 2020 Jun 9;11:828. doi: 10.3389/fphar.2020.00828. PMID: 32581794; PMCID: PMC7295938.
Higher Epoxyeicosatrienoic Acids in Cardiomyocytes-Specific CYP2J2 Transgenic Mice Are Associated with Improved Myocardial Remodeling. Aliwarga T, Guo X, Evangelista EA, Lemaitre RN, Sotoodehnia N, Gharib SA, Zeldin DC, Liu Q, Totah RA. Higher Epoxyeicosatrienoic Acids in Cardiomyocytes-Specific CYP2J2 Transgenic Mice Are Associated with Improved Myocardial Remodeling. Biomedicines. 2020 May 30;8(6):144. doi: 10.3390/biomedicines8060144. PMID: 32486275; PMCID: PMC7344501.
CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes. Evangelista EA, Aliwarga T, Sotoodehnia N, Jensen PN, McKnight B, Lemaitre RN, Totah RA, Gharib SA. CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes. Sci Rep. 2020 Mar 24;10(1):5329. doi: 10.1038/s41598-020-62174-w. PMID: 32210298; PMCID: PMC7093536.
2019
Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8. Kahma H, Filppula AM, Launiainen T, Viinamäki J, Neuvonen M, Evangelista EA, Totah RA, Backman JT. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8. Drug Metab Dispos. 2019 Apr;47(4):436-443. doi: 10.1124/dmd.118.085498. Epub 2019 Feb 1. PMID: 30709838.
2018
A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma. Zeigler M, Whittington D, Sotoodehnia N, Lemaitre RN, Totah RA. A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma. Chem Phys Lipids. 2018 Nov;216:162-170. doi: 10.1016/j.chemphyslip.2018.09.004. Epub 2018 Sep 7. PMID: 30201384; PMCID: PMC6269592.
Regulation of CYP2J2 and EET Levels in Cardiac Disease and Diabetes. Aliwarga T, Evangelista EA, Sotoodehnia N, Lemaitre RN, Totah RA. Regulation of CYP2J2 and EET Levels in Cardiac Disease and Diabetes. Int J Mol Sci. 2018 Jun 29;19(7):1916. doi: 10.3390/ijms19071916. PMID: 29966295; PMCID: PMC6073148.
CYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species Toxicity. Evangelista EA, Lemaitre RN, Sotoodehnia N, Gharib SA, Totah RA. CYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species Toxicity. Drug Metab Dispos. 2018 Apr;46(4):380-386. doi: 10.1124/dmd.117.078840. Epub 2018 Jan 17. PMID: 29343610; PMCID: PMC5829540.
2017
Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae. McDonald MG, Ray S, Amorosi CJ, Sitko KA, Kowalski JP, Paco L, Nath A, Gallis B, Totah RA, Dunham MJ, Fowler DM, Rettie AE. Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae. Drug Metab Dispos. 2017 Dec;45(12):1364-1371. doi: 10.1124/dmd.117.078188. Epub 2017 Oct 10. PMID: 29018033; PMCID: PMC5697098.
Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo. Aliwarga T, Raccor BS, Lemaitre RN, Sotoodehnia N, Gharib SA, Xu L, Totah RA. Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo. Free Radic Biol Med. 2017 Nov;112:131-140. doi: 10.1016/j.freeradbiomed.2017.07.015. Epub 2017 Jul 19. PMID: 28734877; PMCID: PMC5623104.
2015
The role of cytochrome P450 BM3 phenylalanine-87 and threonine-268 in binding organic hydroperoxides. Roberts AG, Katayama J, Kaspera R, Ledwitch KV, Le Trong I, Stenkamp RE, Thompson JA, Totah RA. The role of cytochrome P450 BM3 phenylalanine-87 and threonine-268 in binding organic hydroperoxides. Biochim Biophys Acta. 2016 Apr;1860(4):669-77. doi: 10.1016/j.bbagen.2015.12.014. Epub 2015 Dec 23. PMID: 26723172.
Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer. Johnson AL, Edson KZ, Totah RA, Rettie AE. Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer. Adv Pharmacol. 2015;74:223-62. doi: 10.1016/bs.apha.2015.05.002. Epub 2015 Jun 27. PMID: 26233909; PMCID: PMC4667791. 27. Review.
2014
Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo. Kaspera R, Kirby BJ, Sahele T, Collier AC, Kharasch ED, Unadkat JD, Totah RA. Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo. Biochem Pharmacol. 2014 Sep 1;91(1):109-18. doi: 10.1016/j.bcp.2014.06.020. Epub 2014 Jun 25. PMID: 24973543; PMCID: PMC4169885.