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“Two roads diverged in a wood, and I—
I took the one less traveled by,
And that has made all the difference.”

– Robert Frost, The Road Not Taken

The Bomsztyk lab is developing high-throughput technologies for multi-omics applications to reverse-engineer disease and aging molecular pathology. The technologies consist of tissue storing and sampling (CryoGrid ), microplate sample preparation (PIXUL), and microplate analytical (Matrix) platforms linked to qPCR,  the next generation sequencing (NGS) and mass spectrometry (MS). These techniques are user friendly generating large amounts of data from cell cultures and frozen and FFPE tissue blocks.

These platforms, along with computational algorithms, are being applied to several diseases, as well as aging, related areas, such as acute and chronic organ injury, cancer and diabetes. These high-throughput technologies and machine learning tools provide opportunities to discover disease pathways, biomarkers, and potential drug targets.