Yang Liu joined Tureček group since winter quarter of 2015. Her PhD study involved in two major topics of research: (1) Development of multiplex tandem mass spectrometry assay for newborn screening (NBS) of lysosomal storage disorders (LSDs); (2) Development of mass spectrometry techniques in combination with computational modeling to elucidate the conformational structure of physiologically active molecules (noncovalent complexes and unusual radical species) in the gas phase. During her PhD study she also took a side track of data science (DIRECT program sponsored by Clean Energy Institute) with focus on machine learning on chemical patterns.

Publications before UW:

  1. Yu, L. X., Liu, Y., Chen, S. C., Guan, Y., & Wang, Y. Z. (2014). Reversible photoswitching aggregation and dissolution of spiropyran-functionalized copolymer and light-responsive FRET process. Chinese Chemical Letters, 25(3), 389-396.
  2. Scott, C. R., Elliott, S., Spacil, Z., Masai, S., Liu, Y., Liao, H. C., … & Feng, J. (2016). The performance characteristics of a 6-plex assay for the detection of six lysosomal diseases and preliminary data for the detection of MPS II, MPS IVA and MPS VI. Molecular Genetics and Metabolism, 2(117), S104.

Publications at UW:

  1. Pepin, R., Layton, E. D., Liu, Y., Afonso, C., & Tureček, F. (2016). Where does the electron go? Stable and metastable peptide cation radicals formed by electron transfer. Journal of The American Society for Mass Spectrometry, 28(1), 164-181.
  2. Cournoyer, J., Potier, A., Trometer, J., Schermer, M., Vranish, A., DiPerna, J., Liu, Y., … & Kumar, A. (2017). Six-plex MS/MS method to measure I2S, NAGLU, GALNS, ARSB, GUSB and TPP1 enzyme activities in dried blood spots. Molecular Genetics and Metabolism, 1(120), S37.
  3. Liu, Y., Yi, F., Kumar, A. B., Kumar Chennamaneni, N., Hong, X., Scott, C. R., … & Turecek, F. (2017). Multiplex tandem mass spectrometry enzymatic activity assay for newborn screening of the mucopolysaccharidoses and type 2 neuronal ceroid lipofuscinosis. Clinical chemistry, 63(6), 1118-1126.
  4. Liu, Y., Ramey, Z., & Tureček, F. (2018). Non‐Covalent Interactions of a Neuroprotective Peptide Revealed by Photodissociative Cross‐Linking in the Gas Phase. Chemistry–A European Journal, 24(37), 9259-9263.
  5. Khaledi, H., Liu, Y., Masi, S., & Gelb, M. H. (2018). Detection of infantile batten disease by tandem mass spectrometry assay of PPT1 enzyme activity in dried blood spots. Analytical chemistry, 90(20), 12168-12171.
  6. Liu, Y., Korn, J. A., Dang, A., & Tureček, F. (2018). Hydrogen-Rich Cation Radicals of DNA Dinucleotides: Generation and Structure Elucidation by UV–Vis Action Spectroscopy. The Journal of Physical Chemistry B, 122(42), 9665-9680.
  7. Nguyen, H. T., Huang, S. R., Liu, Y., Liu, Y., Korn, J. A., & Tureček, F. (2019). Probing arginine-phosphopeptide interactions in non-covalent peptide-peptide ion complexes using gas-phase cross-linking and Born-Oppenheimer molecular dynamics calculations. International Journal of Mass Spectrometry, 435, 259-271.
  8. Huang, S. R., Liu, Y., & Tureček, F. (2019). Non-covalent complexes of the peptide fragment Gly-Asn-Asn-Gln-Gln-Asn-Tyr in the gas-phase. Photodissociative cross-linking, Born–Oppenheimer molecular dynamics, and ab initio computational binding study. Physical Chemistry Chemical Physics, 21(4), 2046-2056.
  9. Liu, Y., & Tureček, F. (2019). Photodissociative Cross-Linking of Diazirine-Tagged Peptides with DNA Dinucleotides in the Gas Phase. Journal of The American Society for Mass Spectrometry, 30(10), 1992-2006.
  10. Liu, Y., Korn, J. A., & Tureček, F. (2019). UV-vis action spectroscopy and structures of hydrogen-rich 2′-deoxycytidine dinucleotide cation radicals. A difficult case. International Journal of Mass Spectrometry, 443, 22-31.

Presentations/Conferences:

  1. Poster Presentation: “Multiplex Enzymatic Assay for Newborn Screening of Mucopolysaccharidoses (type II, IIIB, IVA, VI, VII) and Neuronal Ceroid Lipofuscinosis II” 64th American Society for Mass Spectrometry Annual Conference (ASMS), San Antonio, TX. June, 2016.
  2. Poster Presentation: “Diazirine Modification of a Small Peptide as a Probe for Selective Non-covalent Binding via UVPD”  Ion Chemistry and Mass Spectrometry (ICMS), Lake Arrowhead, CA. Jan, 2017.
  3. Oral Presentation: “Gas-phase Peptide Cross-linking for Probing the Nature of Non-covalent Bonding of a Peptide Related to Brain Damage” 65th ASMS,  Indianapolis, IN. Jun, 2017.
  4. Oral Presentation: “Diazirine Photo-Stapler and UVPD in Unraveling the Noncovalent Bonding within DNA/peptide ‘Illogical’ Fragments”, 66th ASMS, San Diego, CA. Jun, 2018.
  5. Oral Presentation: “Gas-phase Photo-crosslinking and MS/MS in Unraveling the Noncovalent Bonding within Physiologically Active Molecule Complexes”, 256th National Meeting of American Chemistry Society (ACS), Boston, MA. Aug, 2018.
  6. Poster Presentation: “Gas-phase photodissociative crosslinking  of diazirine-tagged adrenaline with the binding motif of beta-2 adrenergic receptor”67th ASMS, Atlanta, GA. June, 2019.

Others: