Muscle Research Seminar – Anthony Cammarato – January 27, 2020

Muscle Research Seminar Series

Anthony Cammarato, Ph.D.

Associate Professor in the Division of Cardiology in the Department of Medicine, and the Department of Physiology at Johns Hopkins University School of Medicine

 

“Troponin I is Necessary, but Not Sufficient,
for Striated Muscle Relaxation“

 

Monday, January 27, 2020, 4:00 – 5:00 pm

Room E130A/B, UW Medicine at South Lake Union

850 Republican St., Seattle,WA 98109

To request disability accommodation contact the UW Disability Services Office at: 206.543.6450/V, 206.543.6452/TTY, 206.685.7264/FAX, or dso@uw.edu

Dr. Anthony (Tony) Cammarato is interested in probing basic mechanisms of striated muscle biology, employing an array of imaging modalities to study “structural physiology” of cardiac and skeletal muscle. Drosophila melanogaster, the fruit fly, expresses both forms of striated muscle and benefits greatly from powerful genetic tools. Dr. Cammarato’s lab investigates conserved myopathic processes and performs hierarchical and integrative analysis of muscle function from the level of single molecules and macromolecular complexes through the level of the tissue itself. Additionally, his group examines, in detail, protein quality control mechanisms required to maintain normal skeletal and cardiac muscle protein homeostasis (“proteostasis”). He is interested in what causes the decline of these processes over time and during disease, how to attenuate or prevent their dysfunction, and how to improve functional outcomes, overall, with age. Dr. Cammarato was the first to develop and characterize fly models of diastolic dysfunction and to show that the Drosophila heart proteome is clearly cardiac in its composition. These prototypic studies provide the basis for rigorous in vivo molecular-genetic analysis of muscle mechanics in health and disease.

Sponsors: The Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center at UW is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health under Award Number P50AR065139. The UW Center for Translational Muscle Research  is supported by NIAMS Award Number P30AR074990.