All publications can be viewed on myNCBI.
Hurwitz, S.M., Zagotta, W.N., Gordon, S.E., Hoppins, S. Structural insights into GTP-coupled conformational changes in Mfn1 revealed by time-resolved transition metal ion FRET. BioRxiv https://www.biorxiv.org/cgi/content/short/2025.10.08.681278v1
Stergachis AB, Blue EE, Gillentine MA, Wang LK, Schwarze U, Cortés AS, Ranchalis J, Allworth A, Bland AE, Chanprasert S, Chen J, Doherty D, Folta AB, Glass I, Horike-Pyne M, Huang AY, Khan AT, Leppig KA, Miller DE, Mirzaa G, Parhin A, Raskind WH, Rosenthal EA, Sheppeard S, Strohnbehn S, Sybert VP, Tran TT, Wener MH, University of Washington Center for Mendelian Genomics (UW-CMG), Undiagnosed disease network (UDN), Byers PH, Nelson SF, Bamshad MJ, Dipple KM, Jarvik GP, Hoppins S, Hisama FM. (2023) Full-length isoform sequencing for resolving the Molecular basis of Charcot-Marie-Tooth 2A. Neurol Genet. Aug 8;9(5)e200090. PMC10409571.
Sloat SR, Hoppins S* (2022) A dominant negative mitofusin causes mitochondrial perinuclear clusters due to aberrant tethering. Life Sci Alliance Oct 13:6(1):e202101305. PMID 36229071. PMC9568670.
Hoppins S*, Lackner LL, Lee JE, Mears JA (2020) In vitro and in vivo assays for mitochondrial fission and fusion. Methods Cell Biol 155:491-518. PMID 32183974. PMCID 7863990.
Samanas NB, Engelhart EA, Hoppins S* (2020) Mfn2 requires Hinge 1 integrity for efficient nucleotide-dependent assembly and membrane fusion. Life Sci Alliance Apr 3;3(5):e201900527. PMID 32245838. PMC7136618
Samanas NB and Hoppins S (2020) Cell free analysis of mitochondrial fusion by fluorescence microscopy. Methods Mol. Biol. 2159:129-140. PMID 32529368. PMCID 7863989.
Sloat SR, Whitley BN, Engelhart EA, Hoppins S (2019) Identification of a Mitofusin specificity region that confers unique activities to Mfn1 and Mfn2. Mol. Biol. Cell. 30(17):2309-2319. PMID 31188717
Whitley BN, Engelhart EA, Hoppins S (2019) Mitochondrial dynamics and their potential as a therapeutic target. Mitochondrion 49:269-83. PMID 31228566.
Engelhart EA, Hoppins S (2019) A catalytic domain variant of Mitofusin requiring a wildtype paralog for function uncouples mitochondrial outer membrane tethering and fusion. J. Biol. Chem. 294:8001-8014. PMID 30936207
Whitley BN, Lam C, Cui H, Haude K, Bai R, Escobar L, Hamilton A, Tarnopolsky MA, Brady L, Dengle L, Picker J, Lincoln S, Lackner LL, Glass IA, Hoppins S (2018) Aberrant Drp1-mediated mitochondrial division presents in humans with variable outcomes. Hum. Mol. Genet. 27(21):3710-3719. PMID 30085106
Cunningham CA, Hoppins S, Fink PJ (2018) Glycolytic metabolism and mitochondrial metabolism are uncoupled in antigen-activated CD8+ recent thymic emigrants J. Immunology 201(6):1627-32. PMID 30068985
Hoppins, S. (2014) The regulation of mitochondrial dynamics. Curr. Opin. Cell. Biol. 29:46-52. PMID: 24747170
Hoppins, S., Nunnari, J. (2012) Mitochondrial dynamics and apoptosis – the ER connection. Science 337(6098):1052-4. PMID 22936767i
Hoppins, S.*, Collins, S.C.*, Cassidy-Stone, A., Hummel, E., DeVay, R.M., Lackner, L.L., Westermann, B., Schuldiner, M., Weissman, J.S., Nunnari, J.M. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. Journal of Cell Biology 195(2):323-40. PMID 21987634 (*equal contribution)
Hoppins, S., Edlich, F., Cleland, M., Banerjee, S., McCaffery, J.M., Youle, R., Nunnari, J.M. (2011) The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Molecular Cell 41(2):150-160. PMID 21255726
Hoppins, S., Horner J.S., Song C., McCaffery, J.M. Nunnari, J.M. (2009) Mitochondrial outer and inner membrane fusion required a modified carrier protein. J. Cell Biol. 184(4):569-81. PMID 19237599
DeVay R.M., Dominguez-Ramirez, L., Lackner, L.L., Hoppins, S., Stahlberg, H., Nunnari J.M. (2009) Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion. J. Cell Biol. 186: 793-803 PMID 19752025
Hoppins, S., Nunnari, J.M. (2009) The molecular mechanism of mitochondrial fusion. Biochim Biophys Acta 1793(1):20-6. PMID 18691613
Hoppins, S.C., Go, N., Klein, A., Schmitt, S., Neupert, W., Rapaport, D., Nargang, F.E. (2007) Alternative splicing gives rise to different isoforms of the Neurospora crassa Tob55 protein that vary in their ability to insert beta-barrel proteins into the outer mitochondrial membrane. Genetics 177(1): 137-49. PMID 17660559
Hoppins, S.*, Lackner, L.L.*, Nunnari, J.M. (2007) The Machines that Divide and Fuse Mitochondria. Annual Review of Biochemistry 76: 751-80. *equal contribution. PMID 17362197
Hoppins, S.C., Nargang, F.E. (2004) The Tim8-Tim13 complex of Neurospora crassa functions in the assembly of proteins into both mitochondrial membranes. J. Biol. Chem. 279(13):12396-405. PMID 14722057
Mokranjac, D., Paschen, S.A., Kozany, C., Prokish, H., Hoppins, S.C., Nargang, F.E., Neupert, W., Hell, K. (2003) Tim50, a novel component of the TIM23 preprotein translocase of mitochondria. EMBO J 22(4):816-25. PMID 12574118