I’m happy to announce that we recently gained IRB approval to investigate the safety of the CorTec Brain Interchange to study stroke rehabilitation using neuroplasticity-inducing stimulation. CorTec has released their own detailed press release here.
Attending Society for Neuroscience 2024 in Chicago!
Once again I’ll be making the trip out to the annual Society for Neuroscience meeting! Come check out the posters with my students and collaborators!
- Oct. 5, 2024, 1:00 PM – 5:00 PM
PSTR017.04 – Neural adaptive deep brain stimulation for gait impairment and freezing of gait in Parkinson’s disease
*C. CUI1, J. CHOI1, S. KARJAGI1, K. B. WILKINS1, A. S. GALA1, C. CASSELTON1, A. NEGI1, P. AKELLA1, T. HOWARD1, L. PARISI1, A. ABAY1, J. A. HERRON3, H. BRONTE-STEWART1,2;
1Neurol. & Neurolog. Sci., 2Dept. of Neurosurg., Stanford Univ., Stanford, CA; 3Dept. of Neurolog. Surgery, Univ. of Washington, Seattle, WA - Oct. 5, 2024, 1:00 PM – 5:00 PM
PSTR017.08 – Kinematic adaptive deep brain stimulation for gait impairment and freezing of gait in Parkinson’s Disease
*S. KARJAGI1, Y. KEHNEMOUYI2, L. PARISI3, P. AKELLA3, E. LAMBERT3, J. MELBOURNE4, A. S. GALA3, C. CUI5, J. O’DAY2, K. B. WILKINS3, M. N. PETRUCCI2, S. ADITHAM3, G. ORTHLIEB3, J. A. HERRON7, H. BRONTE-STEWART6;
1Neurol., Stanford Sch. of Med., Stanford, CA; 2Bioengineering, 3Neurol., 4Stanford, 5Dept. of Neurol. and Neurolog. Sci., 6Neurol. and Neurolog. Sci., Stanford Univ., Stanford, CA; 7Dept. of Neurolog. Surgery, Univ. of Washington, Seattle, WA - Oct. 5, 2024, 1:00 PM – 5:00 PM
PSTR017.09 – Sixty-hertz beta-burst driven adaptive deep brain stimulation for freezing of gait in Parkinson’s disease
*A. S. NEGI1, K. B. WILKINS1, C. CUI1, E. LAMBERT1, J. MELBOURNE1, M. N. PETRUCCI1, S. ADITHAM1, G. ORTHLIEB1, A. S. GALA1, P. AKELLA1, L. PARISI1, J. A. HERRON2, H. BRONTE-STEWART1;
1Neurol. and Neurolog. Sci., Stanford Sch. of Med., Palo Alto, CA; 2Dept. of Neurolog. Surgery, Univ. of Washington, Seattle, WA - Oct. 7, 2024, 8:00 AM – 12:00 PM
PSTR175.14 – Contributions of basal ganglia and cerebellar circuits in speech auditory-motor adaptation: DBS ON/OFF comparisons in patients with Parkinson’s disease vs essential tremor
H. WANG1, J. A. HERRON2, G. CLER1, A. KO2, *L. MAX1;
1Dept. of Speech and Hearing Sci., 2Dept. of Neurolog. Surgery, Univ. of Washington, Seattle, WA - Oct. 8, 2024, 8:00 AM – 12:00 PM
LBA007.052 – Chronic ambulatory DBS recordings reveal neural patterns during sleep that predict OCD symptom severity
*T. KUTCHER1, G. REYES2, Z. NAQVI2, V. ALLAM2, T. B.-L. LIU3, T. FRACZEK4, Y. ZHOU2, A. DENG2, J. A. HERRON6, E. STORCH2, W. K. GOODMAN5, S. A. SHETH3, N. R. PROVENZA3;
1Rice Univ., Houston, TX; 3Neurosurg., 2Baylor Col. of Med., Houston, TX; 4Baylor Col. of Med., Seattle, WA; 5Psychiatry, Baylor Col. of Med., Houston, TX; 6Dept. of Neurolog. Surgery, Univ. of Washington, Seattle, WA - Oct. 8, 2024, 8:00 AM – 12:00 PM
PSTR289.18 – Characterization and demonstration of the evoked potential functionality of the CorTec Brain Interchange
*H. CHO1, A. GKOGKIDIS3, M. BUCHHEIT3, S. C. CRAMER4, J. G. OJEMANN2, T. DENISON5, J. A. HERRON2;
1Electrical and Computer Engin., 2Dept. of Neurolog. Surgery, Univ. of Washington, Seattle, WA; 3CorTec GmbH, Freiburg, Germany; 4Dept. of Neurol., UCLA, Los Angeles, CA; 5Dept. of Engin. Sci., Univ. of Oxford, Oxford, United Kingdom - Oct. 8, 2024, 8:00 AM – 12:00 PM
PSTR289.24 – Report from a long-term study with the Brain Interchange in a healthy sheep model – ECoG-based recording and stimulation
*A. GKOGKIDIS1, M. BUCHHEIT1, H. CHO2, J. A. HERRON3, M. SCHUETTLER1;
1CorTec GmbH, Freiburg, Germany; 2Dept. of Electrical and Computer Engin., 3Dept. of Neurolog. Surgery, Univ. of Washington, Seattle, WA - Oct. 8, 2024, 1:00 PM – 5:00 PM
PSTR330.02 – Characterization of Automated Alignment Onboard Fully Implanted Neuromodulation Systems
*M. O. GOLDSMITH1, M. E. ALARIE2, N. R. PROVENZA4, J. A. HERRON5, W. F. ASAAD3;
1Sch. of Engin., 2Biomed. Engin., 3Neurosurg., Brown Univ., Providence, RI; 4Neurosurg., Baylor Col. of Med., Houston, TX; 5Dept. of Neurolog. Surgery, Univ. of Washington, Seattle, WA - Oct. 8, 2024, 1:00 PM – 5:00 PM
PSTR330.14 – Benchtop environment for assessing artifacts generated during current injection
*J. MORROW1, S. MILLER2, J. A. HERRON3, A. S. WIDGE2;
2Psychiatry, 1Univ. of Minnesota, Minneapolis, MN; 3Dept. of Neurolog. Surgery, Univ. of Washington, Seattle, WA - Oct. 9, 2024, 8:00 AM – 12:00 PM
PSTR418.22 – Investigating Approach-Avoidance Behavior in Obsessive Compulsive Disorder Patients Undergoing Deep Brain Stimulation
*R. BECHTOLD1, A. GANDHI3, J. KANG4, T. B.-L. LIU7, Z. NAQVI5, E. STORCH5, W. K. GOODMAN8, S. A. SHETH6, N. R. PROVENZA6, J. A. HERRON2;
2Dept. of Neurolog. Surgery, 1Univ. of Washington, Seattle, WA; 3Rutgers New Jersey medical school, Newark, NJ; 4Neurosci., 6Neurosurg., 5Baylor Col. of Med., Houston, TX; 7Univ. of Texas at Austin, Houston, TX; 8Psychiatry, NIMH, Bethesda, MD - Oct. 9, 2024, 1:00 PM – 5:00 PM
PSTR481.07 – Enabling chronic neuromodulation research with a robust distributed data framework
*T. M. FRACZEK1, P. J. STEFFAN1, R. A. BECHTOLD4, Y. ZHOU1, J. ADKINSON2, K. KABOTYANSKI2, E. BARTOLI3, B. Y. HAYDEN6, A. WATROUS2, N. VANEGAS1, W. K. GOODMAN7, S. A. SHETH2, J. A. HERRON5, N. R. PROVENZA2;
2Neurosurg., 3Dept. of Neurosurg., 1Baylor Col. of Med., Houston, TX; 4Bioengineering, 5Dept. of Neurolog. Surgery, Univ. of Washington, Seattle, WA; 6Duke Univ., Durham, NC; 7Psychiatry, NIMH, Bethesda, MD
IEEE Transactions of Neural Systems and Rehabilitation Engineering article details methods for upcoming stroke neuroplasticity study
A new paper authored by UW EE PhD student Hanbin Cho details new results in our development of systems to induce neuroplasticity using cortical stimulation with the CorTec Brain Interchange system for individuals who have suffered from stroke. The full paper, which is open access, can be found here.
New NIH-funded UH3 to study the use of Deep Brain Stimulation to treat those with Bipolar Depression
I’m happy to announce that in collaboration with Drs. Wayne Goodman and Sameer Sheth of Baylor College of Medicine, the NIH has decided to fund our proposed study examining the use of deep brain stimulation to treat Bipolar Depression. More information will be coming soon, but in the meantime, the basics of the proposal are on NIH Reporter.
There is also an announcement of the project by the Baylor College of Medicine team here.
New paper detailing the impact of data processing choices on evoked potentials
GridLab neuroscience PhD student Lila Levinson authored a paper breaking down the impact of signal pre-processing decisions on commonly discussed metrics of evoked potentials, highlighting how the lack of standardization of processing techniques can lead to inconsistent results across different groups. The paper was recently published in the Journal of Neuroscience Methods and can be found here.
“Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder” published in Nature Medicine
Work performed in collaboration with Sameer Sheth, Wayne Goodman, and Nicole Provenza at Baylor College of Medicine has established a new biomarker for OCD detailed in a new Nature Medicine publication available here.
Attending the 10th Annual BRAIN Initiative Meeting and presenting a development update with the CorTec Brain Interchange
I’ll be attending the annual BRAIN Initiative Meeting in Washington DC this coming weekend to present our group’s ongoing development progress with the CorTec Brain Interchange to support our upcoming stroke study. The poster is accessible via this link. Also check out the OpenMind Consortium’s poster detailing the impact of our ongoing technological dissemination efforts!
Research progress being presented at 2024 American Society for Stereotactic and Functional Neurosurgery Meeting
My Bioengineering PhD Student Raphael Bechtold and collaborators from Baylor College of Medicine are all heading to Nashville for the 2024 American Society for Stereotactic and Functional Neurosurgery Meeting to present our ongoing work studying the use of neuromodulation therapies for neuropsychiatric disorders! Check out their work –
- Bechtold, N. Provenza, N. Giridharan, A. Allam, S. Rajesh, A. Gandhi, G. Reyes, S. Reddy, E. Storch, S. A. Sheth, W. K. Goodman, and J. Herron, “Offline simulation of adaptive deep brain stimulation algorithm classification for performance characterization during provocation of OCD symptoms”
- Giridharan, N. Provenza, A. Allam, R. Bechtold, N. Diab, S. Rajesh, S. Reddy, G. Reyes, E. Dastin-van Rijn, A. Gandhi, S. Hirani, H. Dang, G. Banks, M. Avendano-Ortega, S. McKay, D. Borton, E. Storch, J. Herron, W. Goodman, S. Sheth “Low-Frequency Power in The Ventral Capsule/Ventral Striatum and Orbitofrontal Cortex: A Neural Biomarker of Obsessive-Compulsive Symptom Severity”
- Provenza, G. Reyes, K, Katlowitz, R. Bechtold, N. Diab, S. Reddy, A. Allam, A. Gandhi, S. Hirani, N. Giridharan, G. Banks, M. Hasen, B. Shofty, B. Hayden, J. Cohn, E. Storch, J. Herron, M. Phillips, W. Goodman, S. Sheth “Deep Brain Stimulation of the Ventral Capsule and Ventral Striatum Drives Approach Behavior and High Beta Power in Ventrolateral Prefrontal Cortex”
- Provenza, S. Reddy, A. Allam, S. Rajesh, N. Diab, R. Caston, K. Katlowitz, A. Gandhi, H. Dang, R. Najera, N. Giridharan, F. Momin, M. Hasen, G. Banks, B. Shofty, B. Hayden, J. Herron, E. Storch, A. Patel, W. Goodman, S. Sheth “DBS Disruption of Neural Rhythms Predicts Shifts in Clinical Response in Obsessive-Compulsive Disorder”
- Kang, W. Mahaphanit, N. Provenza, M. Nassar, A. Allam, R. Bechtold, N. Diab, S. Rajesh, S. Reddy, G. Reyes, E. Dastin-van Rijn, A. Gandhi, S. Hirani, G. Banks, H. Dang, M. Avendano-Ortega, S. McKay, D. Borton, M. Frank, E. Storch, J. Herron, W. Goodman, B. Hayden, S. Sheth “The Effect of Adaptive Deep Brain Stimulation for Obsessive-Compulsive Disorder in Cognitive Self-Control Under Uncertainty”
FDA approves our Investigational Device Exemption for an Early Feasibility Study to rehabilitate stroke patients using CorTec’s Closed-Loop Brain Interchange implant system
We are excited to announce that the FDA approved our Investigational Device Exemption application to make use of the CorTec Brain Interchange in a study seeking to enhance stroke rehabilitation through the use of neuroplasticity-inducing stimulation! Pending IRB approval, we will be seeking individuals with persistent upper limb disability following stroke to participate in this first-of-it’s-kind study with this new device. More information will be coming soon, and for more information check out CorTec’s press release here.
New article in Nature Reviews Bioengineering – “The Convergence of Neuromodulation and Brain-Computer Interfaces”
I’m happy to announce that Nature Reviews Bioengineering published an article I drafted with the OpenMind Consortium leadership team detailing the ongoing technological converging of the fields of Brain Computer Interfaces and Neuromodulation. I encourage you to check it out here!