Research & Clinical Summary
Metabolic mechanisms in cardiovascular diseasesMitochondria-based diagnosis and therapyImmunometabolism
Publications
Cai S, Zhao M, Zhou B, Yoshii A, Bugg D, Villet O, Sahu A, Olson GS, Davis J, Tian R. Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction. J Clin Invest. 2023 Feb 15;133(4):e159498. doi: 10.1172/JCI159498. PMID: 36480284
A Caudal, X Tang, JD Chavez, A Keller, JP Mohr, AA Bakhtina, O Villet, H Chen, B Zhou, MA Walker, R Tian, JE Bruce. Mitochondrial interactome quantitation reveals structural changes in metabolic machinery in the failing murine heart. Nat Cardiovasc Res 2022; 1, 855–866. PMID: 36405497
Zhou B, Wang DD, Qiu Y, Airhart S, Liu Y, Stempien-Otero A, O’Brien KD, Tian R. Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure. J Clin Invest 2020 Nov 2;130(11):6054-6063. PMID: 32790648
Ritterhoff J, Young S, Villet O, Shao D, Neto FC, Bettcher LF, Hsu YA, Kolwicz Jr. SC, Raftery D, Tian R. Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis. Circ Res 2020 Jan 17; 126(2): 182-196. PMID: 31709908
Li T, Zhang Z, Kolwicz Jr. SC, Abell L, Roe ND, Kim M, Zhou B, Cao Y, Ritterhoff J, Gu H, Raftery D, Sun H, Tian R. Defective branched—chain amino acid (BCAA) catabolism disrupts glucose metabolism and sensitizes the heart to ischemia – reperfusion Cell Metab. 2017 Feb 7; 25(2):374—385. PMID: 28178567
Lee CF, Chavez J, Garcia—Menendez L, Choi YS, Roe N, Chiao YA, Edgar J, Goo YA, Goodlett, Bruce J, Tian Normalization of NAD+ Redox Balance as a Therapy for Heart Failure. Circulation 2016 Sep 201; 34(12):883—94. PMID:27489254
Karamanlidis G, Lee CF, Garcia—Menendez L, Kolwicz SC, Suthammarak W, Gong G, Sedensky MM, Morgan PG, Wang W, Tian R. Mitochondria Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure. Cell Metab. 2013 Aug 6;18(2):239—50. PMCID: PMC3779647.