Research and clinical summary
The James lab is interested in uncovering biochemical mechanisms that contribute to drug resistance and to immunological disease. To do so, we investigate many features of protein behavior including their impact on differentiation, their interactions with other molecules and whether mutation regulates these processes. The following are active interests of the lab:
- Leveraging our ability to genetically engineer primary human B cells to create protein-producing cell therapies and to understand the genetic events that promote differentiation into long-lived antibody secreting cells.
- Mapping the effects of each possible variant of genes involved in primary immune deficiency by combining multiplexed genome editing, signaling assays and high throughput DNA sequencing. In the course of these studies, we hope to create look-up tables that can be used by clinicians to help interpret sequencing data from patients.
- Determining which signaling events are required for resistance to targeted therapies and developing therapeutic strategies to block these events.
Interests: Cancer, Cell and Gene Therapy, Cell Signaling, Immunological Disease
Publications
The following publications were retrieved from PubMed:
Henry Osokpo O, James R, Riegel B,
“Maintaining cultural identity: A systematic mixed studies review of cultural influences on the self-care of African immigrants living with non-communicable disease.”
Journal of advanced nursing 77.9 (2021 Sep): 3600-3617.
James R, Flemming K, Hodson M, Oxley T,
“Palliative care for homeless and vulnerably housed people: scoping review and thematic synthesis.”
BMJ supportive & palliative care . (2021 May 3): .
Chapman M, De Graef M, James RD, Chen X,
“Quantitative analysis of compatible microstructure by electron backscatter diffraction.”
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 379.2201 (2021 Jul 12): 20200112.
Coenen J, Cleaver J, James R, Chohan G,
“An Isolated Unilateral Hypoglossal Nerve Palsy Due to a Base of Skull Meningioma.”
Neurology . (2021 May 24): .
Velvaluri P, Soor A, Plucinsky P, de Miranda RL, James RD, Quandt E,
“Origami-inspired thin-film shape memory alloy devices.”
Scientific reports 11.1 (2021 May 26): 10988.
Weber MD, Lim JKB, Glau C, Conlon T, James R, Lee JH,
“A narrative review of diaphragmatic ultrasound in pediatric critical care.”
Pediatric pulmonology 56.8 (2021 Aug): 2471-2483.
Riegel B, James R,
“Comment on rapid reviews.”
European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology 20.5 (2021 Jun 29): 513.
Thomas KR, Allenspach EJ, Camp ND, Wray-Dutra MN, Khim S, Zielinska-Kwiatkowska A, Timms AE, Loftus JP, Liggitt HD, Georgopoulos K, Tasian SK, James RG, Rawlings DJ,
“Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.”
Leukemia . (2021 Jun 30): .
Deery DM, Smith DJ, Davy R, Jimenez-Berni JA, Rebetzke GJ, James RA,
“Impact of Varying Light and Dew on Ground Cover Estimates from Active NDVI, RGB, and LiDAR.”
Plant phenomics (Washington, D.C.) 2021. (2021): 9842178.
Saha SS, Samanas NB, Miralda I, Shubin NJ, Niino K, Bhise G, Acharya M, Seo AJ, Camp N, Deutsch GH, James RG, Piliponsky AM,
“Mast cell surfaceome characterization reveals CD98 heavy chain is critical for optimal cell function.”
The Journal of allergy and clinical immunology . (2021 Jul 27): .