Research & Clinical Summary

Dr. Stanley Lee studies the molecular basis of blood cell development and how its dysregulation can lead to hematologic malignancies such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). His research focuses on defining how disease-causing mutations impact the biology of hematopoietic stem and progenitor cells, and how they drive disease progression and response to therapy. The ultimate goal of Dr. Lee’s research is to translate this knowledge into novel treatments for patients with blood-related disorders including leukemia.

Publications

The following publications were retrieved from PubMed:

Yoshimi A, Balasis ME, Vedder A, Feldman K, Ma Y, Zhang H, Lee SC, Letson C, Niyongere S, Lu SX, Ball M, Taylor J, Zhang Q, Zhao Y, Youssef S, Chung YR, Zhang XJ, Durham BH, Yang W, List AF, Loh ML, Klimek V, Berger MF, Stieglitz E, Padron E, Abdel-Wahab O,
“Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML.”
Blood 130.4 (2017 Jul 27): 397-407.

Seiler M, Yoshimi A, Darman R, Chan B, Keaney G, Thomas M, Agrawal AA, Caleb B, Csibi A, Sean E, Fekkes P, Karr C, Klimek V, Lai G, Lee L, Kumar P, Lee SC, Liu X, Mackenzie C, Meeske C, Mizui Y, Padron E, Park E, Pazolli E, Peng S, Prajapati S, Taylor J, Teng T, Wang J, Warmuth M, Yao H, Yu L, Zhu P, Abdel-Wahab O, Smith PG, Buonamici S,
“H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.”
Nature medicine 24.4 (2018 May): 497-504.

Lee SC, North K, Kim E, Jang E, Obeng E, Lu SX, Liu B, Inoue D, Yoshimi A, Ki M, Yeo M, Zhang XJ, Kim MK, Cho H, Chung YR, Taylor J, Durham BH, Kim YJ, Pastore A, Monette S, Palacino J, Seiler M, Buonamici S, Smith PG, Ebert BL, Bradley RK, Abdel-Wahab O,
“Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.”
Cancer cell 34.2 (2018 Aug 13): 225-241.e8.

Taylor J, Sendino M, Gorelick AN, Pastore A, Chang MT, Penson AV, Gavrila EI, Stewart C, Melnik EM, Herrejon Chavez F, Bitner L, Yoshimi A, Lee SC, Inoue D, Liu B, Zhang XJ, Mato AR, Dogan A, Kharas MG, Chen Y, Wang D, Soni RK, Hendrickson RC, Prieto G, Rodriguez JA, Taylor BS, Abdel-Wahab O,
“Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis.”
Cancer discovery 9.10 (2019 Oct): 1452-1467.

Taylor J, Lee SC,
“Mutations in spliceosome genes and therapeutic opportunities in myeloid malignancies.”
Genes, chromosomes & cancer 58.12 (2019 Dec): 889-902.

Fong JY, Pignata L, Goy PA, Kawabata KC, Lee SC, Koh CM, Musiani D, Massignani E, Kotini AG, Penson A, Wun CM, Shen Y, Schwarz M, Low DH, Rialdi A, Ki M, Wollmann H, Mzoughi S, Gay F, Thompson C, Hart T, Barbash O, Luciani GM, Szewczyk MM, Wouters BJ, Delwel R, Papapetrou EP, Barsyte-Lovejoy D, Arrowsmith CH, Minden MD, Jin J, Melnick A, Bonaldi T, Abdel-Wahab O, Guccione E,
“Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.”
Cancer cell 36.2 (2019 Aug 12): 194-209.e9.

Yoshimi A, Lin KT, Wiseman DH, Rahman MA, Pastore A, Wang B, Lee SC, Micol JB, Zhang XJ, de Botton S, Penard-Lacronique V, Stein EM, Cho H, Miles RE, Inoue D, Albrecht TR, Somervaille TCP, Batta K, Amaral F, Simeoni F, Wilks DP, Cargo C, Intlekofer AM, Levine RL, Dvinge H, Bradley RK, Wagner EJ, Krainer AR, Abdel-Wahab O,
“Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.”
Nature 574.7777 (2019 Oct): 273-277.

Inoue D, Chew GL, Liu B, Michel BC, Pangallo J, D’Avino AR, Hitchman T, North K, Lee SC, Bitner L, Block A, Moore AR, Yoshimi A, Escobar-Hoyos L, Cho H, Penson A, Lu SX, Taylor J, Chen Y, Kadoch C, Abdel-Wahab O, Bradley RK,
“Spliceosomal disruption of the non-canonical BAF complex in cancer.”
Nature 574.7778 (2019 Oct): 432-436.

Klossowski S, Miao H, Kempinska K, Wu T, Purohit T, Kim E, Linhares BM, Chen D, Jih G, Perkey E, Huang H, He M, Wen B, Wang Y, Yu K, Lee SC, Danet-Desnoyers G, Trotman W, Kandarpa M, Cotton A, Abdel-Wahab O, Lei H, Dou Y, Guzman M, Peterson L, Gruber T, Choi S, Sun D, Ren P, Li LS, Liu Y, Burrows F, Maillard I, Cierpicki T, Grembecka J,
“Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.”
The Journal of clinical investigation 130.2 (2020 Feb 3): 981-997.

Lee S, Aly A, Bhakta P, Parameswaran K, Chorny V, Pinto R, Zeng J, Hong R, Braiman M,
“Case 3: Rapidly Expanding Neck Mass Leading to Cardiopulmonary Arrest in a 14-year-old Boy.”
Pediatrics in review 41.1 (2020 Jan): 34-37.

Izzo F, Lee SC, Poran A, Chaligne R, Gaiti F, Gross B, Murali RR, Deochand SD, Ang C, Jones PW, Nam AS, Kim KT, Kothen-Hill S, Schulman RC, Ki M, Lhoumaud P, Skok JA, Viny AD, Levine RL, Kenigsberg E, Abdel-Wahab O, Landau DA,
“DNA methylation disruption reshapes the hematopoietic differentiation landscape.”
Nature genetics 52.4 (2020 Apr): 378-387.

Sohn JH, Chillakuru YR, Lee S, Lee AY, Kelil T, Hess CP, Seo Y, Vu T, Joe BN,
“An Open-Source, Vender Agnostic Hardware and Software Pipeline for Integration of Artificial Intelligence in Radiology Workflow.”
Journal of digital imaging 33.4 (2020 Aug): 1041-1046.

Wang KY, Jadhav SP, Yenduri NJS, Lee SA, Farber HJ, Guillerman RP,
“E-cigarette or vaping product use-associated lung injury in the pediatric population: imaging features at presentation and short-term follow-up.”
Pediatric radiology 50.9 (2020 Aug): 1231-1239.

Kaler J, Hussain A, Lee S,
“Manifestation and Pathogenesis of Sudden Infant Death Syndrome: A Review.”
Critical reviews in eukaryotic gene expression 30.2 (2020): 111-120.

Lee SA, Sayad E, Yenduri NJS, Wang KY, Guillerman RP, Farber HJ,
“Improvement in Pulmonary Function Following Discontinuation of Vaping or E-Cigarette Use in Adolescents with EVALI.”
Pediatric allergy, immunology, and pulmonology 34.1 (2021 Mar): 23-29.