Research & Clinical Summary
Understanding the basic mechanism controlling cell differentiation.
Interests: Cardiovascular Development & Disease, Tissue Injury & Regeneration
Publications
The following publications were retrieved from PubMed:
Nisancioglu MH, Mahoney WM Jr, Kimmel DD, Schwartz SM, Betsholtz C, Genové G,
“Generation and characterization of rgs5 mutant mice.”
Molecular and cellular biology 28.7 (2008 Apr): 2324-31.
Fleming JN, Nash RA, Mahoney WM Jr, Schwartz SM,
“Is scleroderma a vasculopathy?”
Current rheumatology reports 11.2 (2009 Apr): 103-10.
Grabski AD, Shimizu T, Deou J, Mahoney WM Jr, Reidy MA, Daum G,
“Sphingosine-1-phosphate receptor-2 regulates expression of smooth muscle alpha-actin after arterial injury.”
Arteriosclerosis, thrombosis, and vascular biology 29.10 (2009 Oct): 1644-50.
Mahoney WM Jr, Fleming JN, Schwartz SM,
“A unifying hypothesis for scleroderma: identifying a target cell for scleroderma.”
Current rheumatology reports 13.1 (2011 Feb): 28-36.
Gunaje JJ, Bahrami AJ, Schwartz SM, Daum G, Mahoney WM Jr,
“PDGF-dependent regulation of regulator of G protein signaling-5 expression and vascular smooth muscle cell functionality.”
American journal of physiology. Cell physiology 301.2 (2011 Aug): C478-89.
Majesky MW, Dong XR, Hoglund V, Mahoney WM Jr, Daum G,
“The adventitia: a dynamic interface containing resident progenitor cells.”
Arteriosclerosis, thrombosis, and vascular biology 31.7 (2011 Jul): 1530-9.
Majesky MW, Dong XR, Hoglund V, Daum G, Mahoney WM Jr,
“The adventitia: a progenitor cell niche for the vessel wall.”
Cells, tissues, organs 195.1-2 (2012): 73-81.
Weyers JJ, Carlson DD, Murry CE, Schwartz SM, Mahoney WM Jr,
“Retrograde perfusion and filling of mouse coronary vasculature as preparation for micro computed tomography imaging.”
Journal of visualized experiments : JoVE .60 (2012 Feb 10): e3740.
Mahoney WM Jr, Gunaje J, Daum G, Dong XR, Majesky MW,
“Regulator of G-protein signaling – 5 (RGS5) is a novel repressor of hedgehog signaling.”
PloS one 8.4 (2013): e61421.
Weyers JJ, Schwartz SM, Minami E, Carlson DD, Dupras SK, Weitz K, Simons M, Cox TC, Murry CE, Mahoney WM Jr,
“Effects of cell grafting on coronary remodeling after myocardial infarction.”
Journal of the American Heart Association 2.3 (2013 May 30): e000202.
Ieronimakis N, Hays AL, Janebodin K, Mahoney WM Jr, Duffield JS, Majesky MW, Reyes M,
“Coronary adventitial cells are linked to perivascular cardiac fibrosis via TGFβ1 signaling in the mdx mouse model of Duchenne muscular dystrophy.”
Journal of molecular and cellular cardiology 63. (2013 Oct): 122-34.
Hayes BJ, Riehle KJ, Shimizu-Albergine M, Bauer RL, Hudkins KL, Johansson F, Yeh MM, Mahoney WM Jr, Yeung RS, Campbell JS,
“Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis.”
PloS one 9.3 (2014): e92925.
Chong JJ, Yang X, Don CW, Minami E, Liu YW, Weyers JJ, Mahoney WM, Van Biber B, Cook SM, Palpant NJ, Gantz JA, Fugate JA, Muskheli V, Gough GM, Vogel KW, Astley CA, Hotchkiss CE, Baldessari A, Pabon L, Reinecke H, Gill EA, Nelson V, Kiem HP, Laflamme MA, Murry CE,
“Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.”
Nature 510.7504 (2014 Jun 12): 273-7.
Bahrami AJ, Gunaje JJ, Hayes BJ, Riehle KJ, Kenerson HL, Yeung RS, Stempien-Otero AS, Campbell JS, Mahoney WM Jr,
“Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury.”
PloS one 9.10 (2014): e108505.
Weyers JJ, Gunaje JJ, Van Biber B, Martinson A, Reinecke H, Mahoney WM, Schwartz SM, Cox TC, Murry CE,
“Sonic Hedgehog upregulation does not enhance the survival and engraftment of stem cell-derived cardiomyocytes in infarcted hearts.”
PloS one 15.1 (2020): e0227780.