Research & Clinical Summary

Dr. Andrew McGuire is a molecular and cellular biologist who works on the design of HIV vaccines. His research is focused on developing immunogens — molecules that would cause the immune system to generate protective proteins, or neutralizing antibodies, to block the virus. Because HIV mutates so rapidly, conventional antibodies do not provide lasting protection. So, Dr. McGuire is working on coaxing the immune system to generate so-called broadly neutralizing antibodies, which are difficult for HIV to evade and more effective at protecting against different strains. His lab also works on the design of vaccines against Epstein-Barr virus, which can cause mononucleosis and certain cancers.

Interests: Immunology, Infectious Disease, Inflammation, Vaccines

Publications

The following publications were retrieved from PubMed:

Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D,
“Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.”
Cell 183.6 (2020 Dec 10): 1735.

Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad L, Acton O, Bowen J, Wang C, Xiong X, de van der Schueren W, Quispe J, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D,
“Structural basis for broad coronavirus neutralization.”
bioRxiv : the preprint server for biology . (2021 Jan 4): .

McGuire A, Krysa N, Mann S,
“Hair of the Dog? Periprosthetic Joint Infection with Streptococcus can is.”
Arthroplasty today 8. (2021 Apr): 53-56.

Tauzin A, Nayrac M, Benlarbi M, Gong SY, Gasser R, Beaudoin-Bussières G, Brassard N, Laumaea A, Vézina D, Prévost J, Anand SP, Bourassa C, Gendron-Lepage G, Medjahed H, Goyette G, Niessl J, Tastet O, Gokool L, Morrisseau C, Arlotto P, Stamatatos L, McGuire AT, Larochelle C, Uchil P, Lu M, Mothes W, Serres G, Moreira S, Roger M, Richard J, Martel-Laferrière V, Duerr R, Tremblay C, Kaufmann DE, Finzi A,
“A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responses.”
bioRxiv : the preprint server for biology . (2021 Mar 18): .

Stamatatos L, Czartoski J, Wan YH, Homad LJ, Rubin V, Glantz H, Neradilek M, Seydoux E, Jennewein MF, MacCamy AJ, Feng J, Mize G, De Rosa SC, Finzi A, Lemos MP, Cohen KW, Moodie Z, McElrath MJ, McGuire AT,
“A single mRNA immunization boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection.”
medRxiv : the preprint server for health sciences . (2021 Mar 10): .

Stamatatos L, Czartoski J, Wan YH, Homad LJ, Rubin V, Glantz H, Neradilek M, Seydoux E, Jennewein MF, MacCamy AJ, Feng J, Mize G, De Rosa SC, Finzi A, Lemos MP, Cohen KW, Moodie Z, McElrath MJ, McGuire AT,
“mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection.”
Science (New York, N.Y.) . (2021 Mar 25): .

Jennewein MF, MacCamy AJ, Akins NR, Feng J, Homad LJ, Hurlburt NK, Seydoux E, Wan YH, Stuart AB, Edara VV, Floyd K, Vanderheiden A, Mascola JR, Doria-Rose N, Wang L, Yang ES, Chu HY, Torres JL, Ozorowski G, Ward AB, Whaley RE, Cohen KW, Pancera M, McElrath MJ, Englund JA, Finzi A, Suthar MS, McGuire AT, Stamatatos L,
“Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects.”
bioRxiv : the preprint server for biology . (2021 Mar 24): .

Ullah I, Prévost J, Ladinsky MS, Stone H, Lu M, Anand SP, Beaudoin-Bussières G, Symmes K, Benlarbi M, Ding S, Gasser R, Fink C, Chen Y, Tauzin A, Goyette G, Bourassa C, Medjahed H, Mack M, Chung K, Wilen CB, Dekaban GA, Dikeakos JD, Bruce EA, Kaufmann DE, Stamatatos L, McGuire AT, Richard J, Pazgier M, Bjorkman PJ, Mothes W, Finzi A, Kumar P, Uchil PD,
“Live Imaging of SARS-CoV-2 Infection in Mice Reveals Neutralizing Antibodies Require Fc Function for Optimal Efficacy.”
bioRxiv : the preprint server for biology . (2021 Jun 28): .

Divine R, Dang HV, Ueda G, Fallas JA, Vulovic I, Sheffler W, Saini S, Zhao YT, Raj IX, Morawski PA, Jennewein MF, Homad LJ, Wan YH, Tooley MR, Seeger F, Etemadi A, Fahning ML, Lazarovits J, Roederer A, Walls AC, Stewart L, Mazloomi M, King NP, Campbell DJ, McGuire AT, Stamatatos L, Ruohola-Baker H, Mathieu J, Veesler D, Baker D,
“Designed proteins assemble antibodies into modular nanocages.”
Science (New York, N.Y.) 372.6537 (2021 Apr 2): .

Boonyaratanakornkit J, Singh S, Weidle C, Rodarte J, Bakthavatsalam R, Perkins J, Stewart-Jones GBE, Kwong PD, McGuire AT, Pancera M, Taylor JJ,
“Protective antibodies against human parainfluenza virus type 3 infection.”
mAbs 13.1 (2021 Jan-Dec): 1912884.

Seydoux E, Wan YH, Feng J, Wall A, Aljedani S, Homad LJ, MacCamy AJ, Weidle C, Gray MD, Brumage L, Taylor JJ, Pancera M, Stamatatos L, McGuire AT,
“Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.”
Cell reports 35.5 (2021 May 4): 109084.

Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad L, Acton OJ, Bowen JE, Wang C, Xiong X, de van der Schueren W, Quispe J, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D,
“Structural basis for broad coronavirus neutralization.”
Nature structural & molecular biology 28.6 (2021 Jun): 478-486.

Tauzin A, Nayrac M, Benlarbi M, Gong SY, Gasser R, Beaudoin-Bussières G, Brassard N, Laumaea A, Vézina D, Prévost J, Anand SP, Bourassa C, Gendron-Lepage G, Medjahed H, Goyette G, Niessl J, Tastet O, Gokool L, Morrisseau C, Arlotto P, Stamatatos L, McGuire AT, Larochelle C, Uchil P, Lu M, Mothes W, De Serres G, Moreira S, Roger M, Richard J, Martel-Laferrière V, Duerr R, Tremblay C, Kaufmann DE, Finzi A,
“A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses.”
Cell host & microbe 29.7 (2021 Jul 14): 1137-1150.e6.

Jennewein MF, MacCamy AJ, Akins NR, Feng J, Homad LJ, Hurlburt NK, Seydoux E, Wan YH, Stuart AB, Edara VV, Floyd K, Vanderheiden A, Mascola JR, Doria-Rose N, Wang L, Yang ES, Chu HY, Torres JL, Ozorowski G, Ward AB, Whaley RE, Cohen KW, Pancera M, McElrath MJ, Englund JA, Finzi A, Suthar MS, McGuire AT, Stamatatos L,
“Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects.”
Cell reports 36.2 (2021 Jul 13): 109353.

Seydoux E, Wan YH, Feng J, Wall A, Aljedani S, Homad LJ, MacCamy AJ, Weidle C, Gray MD, Brumage L, Taylor JJ, Pancera M, Stamatatos L, McGuire AT,
“Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.”
Cell reports 36.3 (2021 Jul 20): 109454.