Research & Clinical Summary
The Nabet lab is dedicated to targeting oncogenic signaling networks through the control of protein homeostasis to advance new therapeutic strategies in cancer. We use multidisciplinary approaches including the development of degradation-based technologies to discover, validate, and gain insights into clinically relevant targets. Through these efforts we work to deepen our biological understanding of the molecular circuits that drive cancer cell survival and growth as well as translate these insights into new therapeutic solutions for unmet medical needs.
The Nabet Lab is currently accepting M3D students for first-year quarterly rotations.
Publications
Koide E, Mohardt ML, Doctor ZM, Yang A, Hao M, Donovan KA, Kuismi CC, Nelson AJ, Abell K, Aguiar M, Che J, Stokes MP, Zhang T, Aguirre AJ, Fischer ES, Gray NS, Jiang B#, Nabet B#. Development and characterization of selective FAK inhibitors and PROTACs with in vivo activity. ChemBioChem. 2023 Oct 4;24(19):e202300141. (#Co-Corresponding Author)
Kuismi CC, Nabet B. Lighting the way to tumor destruction. Trends in Pharmacological Sciences. 2023 Sep 25:S0165-6147(23)00205-5.
Olson AT, Kang Y, Ladha AM, Zhu S, Lim CB, Nabet B, Lagunoff M, Gujral TS, Geballe AP. Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation. PLoS Pathogens. 2023 Sep 5;19(9):e1011169.
Yao Y, Fong Ng J, Park WD, Samur MK, Morelli E, Encinas J, Chyra Z, Xu Y, Derebail S, Epstein CB, Nabet B, Chesi M, Gray NS, Young R, Kwiatkowski N, Mitsiades CS, Anderson KC, Lin CY, Munshi NC, Fulciniti M. CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma. Blood. 2023 Jun 8;141(23):2841-2852.
Trory JS, Munkacsi A, Śledź KM, Vautrinot J, Goudswaard LJ, Jackson ML, Heesom KJ, Moore SF, Poole AW, Nabet B, Aggarwal VK, Hers I. Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function. Blood Advances. 2023 May 9;7(9):1692-1696.
Lu W, Fan M, Ji W, Tse J, You I, Ficarro SB, Tavares I, Che J, Kim AY, Zhu X, Boghossian A, Rees MG, Ronan MM, Roth JA, Hinshaw SM, Nabet B, Corsello SM, Kwiatkowski N, Marto JA, Zhang T, Gray NS. Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors. Journal of Medicinal Chemistry. 2023 Apr 13;66(7):4617-4632.