Research & Clinical Summary
The goal of our research (in the Yang lab) is to utilize pluripotent stem cell and animal models as well as clinical samples to study conditions that affect reproductive and maternal-fetal health. Current research projects include:
- Characterization of aneuploidy, cell fate and mosaicism in early development
- Modeling placentation anomalies using trophoblast stem cells
- Profiling the epigenetic regulation of cell fate transition in human embryos
Publications
Yang M, Tao X, Scott K, Zhan Y, Scott RT, Seli E. Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences. Hum Reprod. 2021 May 17;36(6):1682-1690. doi: 10.1093/humrep/deab074. PubMed PMID: 33846747.
Yang M, Rito T, Metzger J, Naftaly J, Soman R, Hu J, Albertini DF, Barad DH, Brivanlou AH, Gleicher N. Depletion of aneuploid cells in human embryos and gastruloids. Nat Cell Biol. 2021 Apr;23(4):314-321. doi: 10.1038/s41556-021-00660-7. Epub 2021 Apr 9. PubMed PMID: 33837289.
Wang B, Yang M, Li S. Numb and Numblike regulate sarcomere assembly and maintenance. J Clin Invest. 2022 Feb 1;132(3). doi: 10.1172/JCI139420. PubMed PMID: 35104799; PubMed Central PMCID: PMC8803338.
Yang M, Tao X, Titus S, Zhao T, Scott RT, Seli E. Analysis of accessible chromatin landscape in the inner cell mass and trophectoderm of human blastocysts. Mol Hum Reprod. 2020 Sep 1;26(9):702-711. doi: 10.1093/molehr/gaaa048. PubMed PMID: 32663300.
Gash KK, Yang M, Fan Z, Regouski M, Rutigliano HM, Polejaeva IA. Assessment of microchimerism following somatic cell nuclear transfer and natural pregnancies in goats. J Anim Sci. 2019 Sep 3;97(9):3786-3794. doi: 10.1093/jas/skz248. PubMed PMID: 31353395; PubMed Central PMCID: PMC6735858.
Fan Z, Yang M, Regouski M, Polejaeva IA. Gene Knockouts in Goats Using CRISPR/Cas9 System and Somatic Cell Nuclear Transfer. Methods Mol Biol.2019;1874:373-390. doi: 10.1007/978-1-4939-8831-0_22. PubMed PMID: 30353526.
Yang M, Perisse I, Fan Z, Regouski M, Meyer-Ficca M, Polejaeva IA. Increased pregnancy losses following serial somatic cell nuclear transfer in goats.Reprod Fertil Dev. 2018 Oct;30(11):1443-1453. doi: 10.1071/RD17323. PubMed PMID: 29769162.
Zhou G, Wei H, Wang X, Yang M, Bunch TD, Polejaeva IA, White KL, Wang Z, Meng Q. Serial Culture Is Critical for In Vitro Development of Parthenogenetic Embryos in the Golden Syrian Hamster. Cell Reprogram. 2018 Jun;20(3):187-195. doi: 10.1089/cell.2017.0070. Epub 2018 Apr 24. PubMed PMID: 29688743; PubMed Central PMCID: PMC6421986.
Yang. Effects of three different media on in vitro maturation and development, intracellular glutathione and reactive oxygen species levels, and maternal gene expression of abattoir-derived goat oocytes. Small ruminant research : the journal of the International Goat Association. 2017 February; 147:106-114.
Yang M, Hall J, Fan Z, Regouski M, Meng Q, Rutigliano HM, Stott R, Rood KA, Panter KE, Polejaeva IA. Oocytes from small and large follicles exhibit similar development competence following goat cloning despite their differences in meiotic and cytoplasmic maturation. Theriogenology. 2016 Dec;86(9):2302-2311. doi: 10.1016/j.theriogenology.2016.07.026. Epub 2016 Aug 10. PubMed PMID: 27650944.
Ni W, Qiao J, Hu S, Zhao X, Regouski M, Yang M, Polejaeva IA, Chen C. Efficient gene knockout in goats using CRISPR/Cas9 system. PLoS One.2014;9(9):e106718. doi: 10.1371/journal.pone.0106718. eCollection 2014. PubMed PMID: 25188313; PubMed Central PMCID: PMC4154755.