While the majority of antiseizure drug (ASD) discovery has come on the back of rodent models of seizure and epilepsy, efficacy has been primarily established in male, young adult rodents. In this regard, little work has been conducted until recent years to initially understand whether novel agents are effective and well-tolerated in rodents of young or advanced age.

Our lab is now focused on applying our expertise in mouse and rat ASD discovery models to evaluate the efficacy of ASDs in aged rodents. There is a significant need to improve our understanding of ASD efficacy and tolerability in the elderly, who represent the fastest growing patient demographic with epilepsy diagnosis.