Theiler’s murine encephalomyelitis virus (TMEV) is a single-stranded RNA murine cardiovirus from the family Picornaviridae. It is useful to model virally-induced acute seizures and encephalitis-induced epileptogenesis. Because epilepsy is an underrecognized long-term complication of central nervous system (CNS) infection, the TMEV model is invaluable to understand the complex interactions between viruses, the immune system, and Read More…
Tag: soticlestat
Soticlestat: a selective, potent inhibitor of the enzyme cholesterol 24-hydroxylase
Soticlestat, formerly known as TAK-935/OV935, is an investigational drug developed by Takeda Pharmaceuticals. It is a highly selective, potent inhibitor of the enzyme cholesterol 24-hydroxylase, which plays a crucial role in the regulation of neurosteroid synthesis. Neurosteroids are naturally occurring molecules in the brain that modulate neuronal activity, including in epilepsy. Our recent study adds Read More…