This blog post delves into the observations of sex differences in cognitive function in older rodent models, exploring the factors that contribute to these disparities and their implications for our understanding of aging in humans. It is likely that men and women experience cognitive aging differently. While the exact reasons are complex and multifaceted, several Read More…
Category: Students
Heterogeneity of Seizure Susceptibility in Alzheimer’s disease
Alzheimer’s disease (AD) is a devastating neurodegenerative disease that affects over 4 million people in the US alone. As the worldwide population continues to age, this number will only grow in the coming decades. Seizures in people with both early- and late-onset AD are more common than in similarly age-matched non-affected individuals. People with epilepsy Read More…
A novel plasma biomarker for seizures?
Gasotransmitters are a relatively untapped therapeutic target in epilepsy. The carbonic anhydrase inhibitor, acetazolamide, is an approved antiseizure drug, and low levels of CO2 have been linked with asynchronous neuronal firing and higher seizure propensity. Nitric oxide is another critical signaling molecule that has undergone a high degree of scrutiny in epilepsy and other neurological Read More…
Body weight influences spontaneous recurrent seizure burden
The kainic acid (KA)-induced status epilepticus model evoked in rats is commonly used in the search for both acutely anticonvulsant and disease-modifying therapies in both mice and rats. This model includes an acute status epilepticus insult that then is followed by a latent phase prior to the development of spontaneous recurrent seizures; e.g. epilepsy. While Read More…
Cross Continent Collaboration
Back in 2018, when we could still freely travel the world for scientific collaboration, our lab was approached by a colleague in the UK interested in a new drug discovery collaboration. Dr. Alan Morgan, Professor of Cellular and Molecular Physiology at the University of Liverpool, contacted our group about profiling a repurposed compound his laboratory Read More…
Virtual UW Undergraduate Research Symposium
Our lab routinely welcomes undergraduate students. We provide an encouraging and collaborative training environment to students who are interested in neuroscience and drug discovery. One of the most exciting highlights of undergraduate training every year is the opportunity for our students to present at the UW Undergraduate Research Symposium. Thousands of undergraduates congregate in Mary Gates Read More…