Theiler’s murine encephalomyelitis virus (TMEV) is a single-stranded RNA murine cardiovirus from the family Picornaviridae. It is useful to model virally-induced acute seizures and encephalitis-induced epileptogenesis. Because epilepsy is an underrecognized long-term complication of central nervous system (CNS) infection, the TMEV model is invaluable to understand the complex interactions between viruses, the immune system, and Read More…
Tag: epilepsy
AES 2021 in REAL LIFE!
After a year of missing catching up with my fellow epilepsy professionals, it has been so exciting to attend the 2021 American Epilepsy Society Annual Meeting in Chicago! I have been enjoying the mix of sightseeing (yes, I saw the “bean”), deep dish pizza (is it really pizza?!), Chicago hot dogs (better than Seattle hot Read More…
Body weight influences spontaneous recurrent seizure burden
The kainic acid (KA)-induced status epilepticus model evoked in rats is commonly used in the search for both acutely anticonvulsant and disease-modifying therapies in both mice and rats. This model includes an acute status epilepticus insult that then is followed by a latent phase prior to the development of spontaneous recurrent seizures; e.g. epilepsy. While Read More…