Publications

2022

Cai S, Zhao M, Zhou B, Yoshii A, Bugg D, Villet O, Sahu A, Olson GS, Davis J, Tian R. Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction. J Clin Invest. 2022 Dec 8;e159498. DOI: 10.1172/JCI159498

Mhatre KN, Murray JD, Flint G, McMillen TS, Weber G, Shakeri M, Tu A-Y, Steczina S, Weiss R, Marcinek DJ, Murry CE, Raftery D, Tian R, Moussavi-Harami F, Regnier M. dATP elevation induces myocardial metabolic remodeling to support improved cardiac function. J Mol Cell Cardiol. 2022 Dec 5;175:1-12. DOI: 10.1016/j.yjmcc.2022.11.010

Caudal A, Tang X, Chavez JD, Keller A, Mohr JP, Bakhtina AA, Villet O, Chen H, Zhou B, Walker MA, Tian R, Bruce JE. Mitochondrial interactome quantitation reveals structural changes in metabolic machinery in the failing murine heart. Nat Cardiovasc Res 2022. DOI: 10.1038/s44161-022-00127-4

Yoshii A, Tian R. Deciphering metabolic remodeling of the failing hearts. Nat Cardiovasc Res 2022. DOI: 10.1038/s44161-022-00118-5

Zhou B, Caudal A, Tang X, Chavez JD, McMillen TS, Keller A, Villet O, Zhao M, Liu Y, Ritterhoff J, Wang P, Kolwicz SC Jr, Wang W, Bruce JE, Tian R. Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts. J Clin Invest. 2022 May 16;132(10):e155333. DOI: 10.1172/JCI155333

Matsuura Y, Shimizu-Albergine M, Barnhart S, Kramer F, Hsu CC, Kothari V, Tang J, Gharib SA, Kanter JE, Abel ED, Tian R, Shao B, Bornfeldt KE. Diabetes Suppresses Glucose Uptake and Glycolysis in Macrophages. Circ Res. 2022 Mar 4;130(5):779-781. DOI: 10.1161/CIRCRESAHA.121.320060

Wang P, Xu S, Xu J, Xin Y, Lu Y, Zhang H, Zhou B, Xu H, Sheu SS, Tian R, Wang W. Elevated MCU Expression by CaMKIIδB Limits Pathological Cardiac Remodeling. Circulation. 2022 Feb 15. DOI: 10.1161/CIRCULATIONAHA.121.055841

Wu J, Singh K, Lin A, Meadows AM, Wu K, Shing V, Bley M, Hassanzadeh S, Huffstutler RD, Schmidt MS, Blanco LP, Tian R, Brenner C, Pirooznia M, Kaplan MJ, Sack MN. Boosting NAD+ blunts toll-like receptor-4 induced type-I interferon in control and systemic lupus erythematosus monocytes. J Clin Invest. 2022. Mar 1;132(5):e139828. DOI: 10.1172/JCI139828

2021

Miklas MW, Levy S, Hofsteen P, Mex DI, Clark E, Muster J, Robitaille AM, Sivaram G, Abell L, Goodson JM, Pranoto I, Madan A, Chin MT, Tian R, Murry CE, Moon RT, Wang Y, Ruohola-Baker H. Amino acid primed mTOR activity is essential for heart regeneration. iScience. 2021 Dec 6;25(1):103574. DOI: 10.1016/j.isci.2021.103574

Hu Q, Wu D, Walker M, Wang P, Tian R, Wang W. Genetically encoded biosensors for evaluating NAD +/NADH ratio in cytosolic and mitochondrial compartments. Cell Rep Methods. 2021 Nov 22;1(7):100116. DOI: 10.1016/j.crmeth.2021.100116

O’Brien KD, Tian R. Boosting mitochondrial metabolism with dietary supplements in heart failure. Nat Rev Cardiol. 2021 Oct;18(10):685-686. DOI: 10.1038/s41569-021-00610-8

Nakamura K, Neidig LE, Yang X, Weber GJ, El-Nachef D, Tsuchida H, Dupras S, Kalucki FA, Jayabalu A, Futakuchi-Tsuchida A, Nakamura DS, Marchianò S, Bertero A, Robinson MR, Cain K, Whittington D, Tian R, Reinecke H, Pabon L, Knollmann BC, Kattman S, Thies RS, MacLellan WB, Murry CE. Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes. Stem Cell Reports. 2021 Oct 12;16(10):2473-2487. DOI: 10.1016/j.stemcr.2021.08.005

Wang DD, Cheng RK, Tian R. Combat doxrubicin cardiotoxicity with the power of mitochondria transfer. JACC CardioOncol. 2021 Sep 21;3(3):441-443. DOI: 10.1016/j.jaccao.2021.08.001

Ritterhoff J, McMillen TS, Villet O, Young S, Kolwicz SC Jr, Senn T, Caudal A, Tian R. Increasing fatty acid oxidation elicits a sex-dependent response in failing mouse hearts. J Mol Cell Cardiol. 2021 Sep;158:1-10. DOI: 10.1016/j.yjmcc.2021.05.004

Chiao YA, Chakraborty AD, Light CM, Tian R, Sadoshima J, Shi X, Gu H, Lee CF. NAD⁺ Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy. Circ Heart Fail. 2021 Aug;14(8):e008170. DOI: 10.1161/CIRCHEARTFAILURE.120.008170

Schiattarella GG, Wang Y, Tian R, Hill JA. Metabolism and Inflammation in Cardiovascular Health and Diseases: Mechanisms to Therapies. J Mol Cell Cardiol. 2021 Aug;157:113-114. DOI: 10.1016/j.yjmcc.2021.02.011

Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED. Cardiac Energy Metabolism in Heart Failure. Circ Res. 2021 May 14;128(10):1487-1513. DOI: 10.1161/CIRCRESAHA.121.318241

Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, Tian R, Lien CL, Pellegrini M, Christofk H, Nakano H, Nakano A. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep. 2021 Apr 21;11(1):8669. DOI: 10.1038/s41598-021-88159-x

Walker MA, Chavez J, Villet O, Tang X, Keller A, Bruce JE, Tian R. Acetylation of muscle creatine kinase negatively impacts high-energy phosphotransfer in heart failure. JCI Insight. 2021 Feb 8. DOI: 10.1172/jci.insight.144301

Deng Y, Xie M, Li Q, Xu X, Ou W, Zhang Y, Xiao H, Yu H, Zheng Y, Liang Y, Jiang C, Chen G, Du D, Zheng W, Wang S, Gong M, Chen Y, Tian R, Li T. Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF. Circ Res. 2021 Jan 22;128(2):232-245. DOI: 10.1161/CIRCRESAHA.120.317933

2020

Zhou B, Wang DD, Qiu Y, Airhart S, Liu Y, Stempien-Otero A, O’Brien KD, Tian R. Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure. J Clin Invest. 2020 Nov 2;130(11):6054-6063. DOI: 10.1172/JCI138538

Shao D, Kolwicz SC, Wang P, Roe ND, Villet O, Nishi K, Hsu YA, Flint GV, Cauda A, Wang W, Regnier M, Tian R. Increasing Fatty Acid Oxidation Prevents High-Fat Diet-Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy. Circulation. 2020 Sep 8;142(10):983-997. DOI: 10.1161/CIRCULATIONAHA.119.043319

Liu Z, Ding J, McMillen TS, Villet O, Tian R, Shao D. Enhancing Fatty Acid Oxidation Negatively Regulates PPARs Signaling in the Heart. J Mol Cell Cardiol. 2020 Sep;146:1-11. DOI: 10.1016/j.yjmcc.2020.06.008

Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. A Novel Approach to Measure Mitochondrial Respiration in Frozen Biological Samples. EMBO J. 2020 Jul 1;39(13):e104073. DOI: 10.15252/embj.2019104073

Zhao M, Wang D D-W, Liu X, Tian R. Metabolic Modulation of Macrophage Function Post Myocardial Infarction. Front. Physiol. 2020 Jun 30. DOI: 10.3389/fphys.2020.00674

Jung HS, Shimizu-Albergine M, Shen X, Kramer F, Shao D, Vivekanandan-Giri A, Pennathur S, Tian R, Kanter JE, Bornfeldt KE. TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells. J Lipid Res. 2020 Jan; 61(1):33-44. DOI: 10.1194/jlr.RA119000256

Ritterhoff J, Young S, Villet O, Shao D, Neto FC, Bettcher LF, Hsu YA, Kolwicz Jr. SC, Raftery D, Tian R. Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis. Circ Res 2020 Jan 17; 126(2): 182-196. DOI: 10.1161/CIRCRESAHA.119.315483

2019

Chavez JD, Keller A, Zhou B, Tian R, Bruce JE. Cellular Interactome Dynamics during Paclitaxel Treatment. Cell Rep. 2019 Nov 19;29(8):2371-2383.e5. DOI: 10.1016/j.celrep.2019.10.063

Yang X, Rodriguez ML, Leonard A, Sun L, Fischer KA, Wang Y, Ritterhoff J, Zhao L, Kolwicz SC Jr, Pabon L, Reinecke H, Sniadecki NJ, Tian R, Ruohola-Baker H, Xu H, Murry CE. Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells.Stem Cell Reports. 2019 Oct 8;13(4):657-668. DOI: 10.1016/j.stemcr.2019.08.013

Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, David W. Busija DW, Dikalov S, Dorn II GW, Galis ZS, Gottlieb GA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O’Brien KD, O’Rourke B, Park JY, Ping P, Sack MN, Sheu S-S, Shi Y, Shiva S, Wallace DC, PhD; Weiss RG, MD, Vernon HJ, Wong R, Schwartz-Longacre L. Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure. Circulation. 2019 Oct 1;140(14):1205-1216. DOI: 10.1161/CIRCULATIONAHA.119.040551

Lee CF, Caudal A, Nagana Abell L, Gowda GA, Tian R. Targeting NAD + Metabolism as Interventions for Mitochondrial Disease. Sci Rep. 2019 Feb 28;9(1):3073. DOI: 10.1038/s41598-019-39419-4

Nagana Gowda GA, Abell L, Tian R. Extending the Scope of 1 H NMR Spectroscopy for the Analysis of Cellular Coenzyme A and Acetyl Coenzyme A. Anal Chem. 2019 Feb 5;91(3):2464-2471. DOI: 10.1021/acs.analchem.8b05286

2018

Zhang H, Gong G, Wang P, Zhang Z, Kolwicz SC, Rabinovitch PS, Tian R, Wang W. Heart Specific Knockout of Ndufs4 Ameliorates Ischemia Reperfusion Injury. J Mol Cell Cardiol. 2018 Oct;123:38-45. PMID: 30165037. DOI: 10.1016/j.yjmcc.2018.08.022.

Zhou B, Tian R. Mitochondrial Dysfunction in Pathophysiology of Heart Failure. J Clin Invest. 2018 Aug 31; 128(9):3716-3726. PMID: 30165037. DOI: 10.1172/JCI120849.

Shao D, Villet O, Zhang Z, Choi SW, Yan J, Ritterhoff J, Gu H, Djukovic D, Christodoulou D, Kolwicz SC Jr, Raftery D, Tian R. Glucose Promotes Cell Growth by Suppressing Branched-Chain Amino Acid Degradation. Nat Commun. 2018 Jul 26; 9(1):2935. PMID: 30050148. DOI: 10.1038/s 41467-018-05362-7

Walker MA, Tian R. NAD(H) in Mitochondrial Energy Transduction: Implications for Health and Disease. Curr Opin Physiol. 2018 Jun;3:101-109. PMID: 32258851. DOI: 10.1016/j.cophys.2018.03.011.

Walker MA, Tian R. Raising NAD in Heart Failure: Time to Translate? Circulation. 2018 May 22;137(21):2274-2277. PMID: 29784680. DOI: 10.1161/CIRCULATIONAHA.117.032626.

Roe ND, Handzlik MK, Li T, Tian R. The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function. Sci Rep. 2018 Mar 21;8(1):4983. PMID: 29563512. DOI: 10.1038/s41598-018-23223-7.

Chavez JD, Lee CF, Caudal A, Tian R, Bruce JE. Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue. Cell Syst. 2018 Jan 24;6(1):136-141.e5. PMID: 29199018. DOI: 10.1016/j.cels.2017.10.017.

Lee CF, Cao Y, Tian R. Failed Power Plant Turns Into Mass Murder: New Insight on Mitochondrial Cardiomyopathy. Circ Res. 2018 Jan 5;122(1)11-13. PMID: 29301837. DOI: 10.1161/CIRCRESAHA.117.312288.

2017

Airhart SE, Shireman LM, Risler LJ, Anderson GD, Nagana Gowda GA, Raftery D, Tian R, Shen DD, O’Brien KD. An Open-Label, Non-Randomized Study of the Pharmacokinetics of the Nutritional Supplement Nicotinamide Riboside (NR) and Its Effects on Blood NAD+ Levels in Healthy Volunteers. PLoS One. 2017 Dec 6;12(12): e0186459. PMID: 29211728. DOI: 10.1371/journal.pone.0186459.

Cao Y, Bojjireddy N, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD, Tian R. Activation of γ2—AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury. Circ Res. 2017 Oct 27;121(10):1182-1191. PMID:28835357. DOI: 10.1161/CIRCRESAHA.117.311159.

Nguyen S, Shao D, Tomasi LC, Braun A, de Mattos ABM, Choi YS, Villet O, Roe N, Halterman CR, Tian R, Kolwicz SC. The Effects of Fatty Acid Composition on Cardiac Hypertrophy and Function in Mouse Models of Diet—Induced Obesity. J Nutr Biochem. 2017 Aug; 46:137-142. PMID: 28605665. DOI: 10.1016/j.jnutbio.2017.05.009.

Ritterhoff J, Tian R. Metabolism in Cardiomyopathy: Every Substrate Matters. Cardiovasc Res. 2017 Mar 15; 113(4):411-421. PMID: 28395011. DOI: 10.1093/cvr/cvx017.

Dai DF, Danoviz ME, Wiczer B, Laflamme MA, Tian R. Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes. Stem Cells Int. 2017, 2017:5153625. PMID: 28421116. DOI: 10.1155/2017/5153625.

Schweppe DK, Chavez JD, Lee CF, Caudal A, Kruse SE, Stuppard R, Marcinek DJ, Shadel GS, Tian R, Bruce JE. Mitochondrial Protein Interactome Elucidated by Chemical Cross-Linking Mass Spectrometry. Proc Natl Acad Sci USA. 2017 Feb 14;114(7):1732-1737. PMID: 28130547. DOI: 10.1073/pnas.1617220114.

Li T, Zhang Z, Kolwicz Jr. SC, Abell L, Roe ND, Kim M, Zhou B, Cao Y, Ritterhoff J, Gu H, Raftery D, Sun H, Tian R. Defective branched—chain amino acid (BCAA) catabolism disrupts glucose metabolism and sensitizes the heart to ischemia—reperfusion injury. Cell Metab. 2017 Feb 7; 25(2):374-385. PMID: 28178567. DOI: 10.1016/j.cmet.2016.11.005.

2016

Choi YS, de Mattos ABM, Shao D, Li T, Nabben M, Kim M, Wang W, Tian R, Kolwicz, Jr. SC. Preservation of Myocardial Fatty Acid Oxidation Prevents Diastolic Dysfunction in Mice Subjected to Angiotensin II Infusion. J Mol Cell Cardiol. 2016 Nov;100:64-71. PMID: 27693463. DOI: 10.1016/j.yjmcc.2016.09.001.

Xu S, Wang P, Zhang H, Gong G, Cortes NG, Zhu W, Yoon Y, Tian R, Wang W. CaMKII Induces Permeability Transition Through Drp1 Phosphorylation During Chronic β-AR Stimulation. Nat Commun. 2016 Oct 14;7:13189. PMID: 27739424. DOI: 10.1038/ncomms13189.

Lee CF, Chavez J, Garcia—Menendez L, Choi YS, Roe N, Chiao YA, Edgar J, Goo YA, Goodlett, Bruce J, Tian R. Normalization of NAD+ Redox Balance as a Therapy for Heart Failure. Circulation 2016 Sep 201; 34(12):883-94. PMID: 27489254. DOI: 10.1161/CIRCULATIONAHA.116.022495.

Nagana Gowda GA, Abell L, Lee CF, Tian R, Raftery D. Simultaneous Analysis of Major Coenzymes of Cellular Redox Reactions and Energy Using ex Vivo (1) H NMR Spectroscopy. Anal Chem. 2016 May 3;88(9):4817-24. PMID: 27043450. DOI: 10.1021/acs.analchem.6b00442.

Lim S, Smith KR, Lim ST, Tian R, Lu J, Tan M. Regulation of Mitochondrial Functions by Protein Phosphorylation and Dephosphorylation. Cell Biosci. 2016 Apr 14; 6:25. PMID: 27087918. DOI: 10.1186/s13578-016-0089-3. Review.

Wang W, Karamanlidis G, Tian R. Novel Targets for Mitochondrial Medicine. Sci Transl Med. 2016 Feb 17; 8(326):326rv3. PMID: 26888432. DOI: 10.1126/scitranslmed.aac7410.

Chiao YA, Kolwicz SC, Basisty N, Gagnidze A, Zhang J, Gu H, Djukovic D, Beyer RP, Raftery D, MacCoss M, Tian R, Rabinovitch PS. Rapamycin Transiently Induces Mitochondrial Remodeling to Reprogram Energy Metabolism in Old Hearts. Aging (Albany NY). 2016 Feb; 8(2):314-27. PMID: 26872208. DOI: 10.18632/aging.100881.

Kolwicz SC Jr, Airhart S, Tian R. Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure? Circulation. 2016 Feb 23;133(8):689-91. PMID: 26819375. DOI: 10.1161/CIRCULATIONAHA.116.021230.

Roe ND, Standage SW, Tian R. The Relationship Between KLF5 and PPARα in the Heart: It’s Complicated. Circ Res. 2016 Jan 22; 118(2):193-5. PMID: 26838311. DOI:10.1161/CIRCRESAHA.115.308069.

2015

Shao D, Tian R. Glucose Transporters in Cardiac Metabolism and Hypertrophy. Compr Physiol. 2015 Dec 15;6(1):331-51. PMID: 26756635. DOI: 10.1002/cphy.c150016.
Lee CF, Tian R. Mitochondrion as a Target for Heart Failure Therapy Role of Protein Lysine Acetylation. Circ J. 2015;79(9):1863-70. PMID: 26248514. DOI: 10.1253/circj.CJ-15-0742. Epub 2015 Aug 4.
Kolwicz SC Jr, Liu L, Goldberg IJ, Tian R. Enhancing Cardiac Triacylglycerol Metabolism Improves Recovery From Ischemic Stress. Diabetes. 2015 Aug; 64(8):2817-27. PMID: 25858561. DOI: 10.2337/db14-1943.
Ma X, Gao L, Karamanlidis G, Gao P, Lee CF, Garcia-Menendez L, Tian R, Tan K. Revealing Pathway Dynamics in Heart Diseases by Analyzing Multiple Differential Networks. PLoS Comput Biol. 2015 Jun 17;11(6): e1004332. PMID: 26083688. DOI: 10.1371/journal.pcbi.1004332.

2014

Nabben M, van Bree BW, Lenaers E, Hoeks J, Hesselink MK, Schaart G, Gijbels MJ, Glatz JF, da Silva GJ, de Windt LJ, Tian R, Mike E, Skapura DG, Wehrens XH, Schrauwen P. Lack of UCP3 Does Not Affect Skeletal Muscle Mitochondrial Function Under Lipid-Challenged Conditions, but Leads to Sudden Cardiac Death. Basic Res Cardiol. 2014 Nov;109(6):447. PMID: 25344084. DOI: 10.1007/s00395-014-0447-4.
Karamanlidis G, Garcia Menendez L, Kolwicz SC Jr, Lee CF, Tian R. Promoting PGC-1α-driven Mitochondrial Biogenesis Is Detrimental in Pressure-Overloaded Mouse Hearts. Am J Physiol Heart Circ Physiol. 2014 Nov 1;307(9):H1307-16. PMID: 25172896. DOI: 10.1152/ajpheart.00280.2014.
Kim M, Hunter RW, Garcia-Menendez L, Gong G, Yang YY, Kolwicz SC Jr, Xu J, Wang W, Sakamoto K, Tian R.Mutation in the γ2-subunit of AMP-activated Protein Kinase Stimulates Cardiomyocyte Proliferation and Hypertrophy Independent of Glycogen Storage. Circ Res. 2014 Mar 14;114(6):966-75. PMID: 24503893. DOI: 10.1161/CIRCRESAHA.114.302364.
Hohl M, Ardehali H, Azuaje FJ, Breckenridge RA, Doehner W, Eaton P, Ehret GB, Fujita T, Gaetani R, Giacca M, Hasenfuß G, Heymans S, Leite—Moreira AF, Linke WA, Linz D, Lyon A, Mamas MA, Orešič M, Papp Z, Pedrazzini T, Piepoli M, Prosser B, Rizzuto R, Tarone G, Tian R, van Craenenbroeck E, van Rooij E, Wai T, Weiss G, Maack C. Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research. Eur J Heart Fail. 2014 Jan;16(1):6-14. PMID: 24453095. DOI: 10.1002/ejhf.10.
Yu Q, Lee CF, Wang W, Karamanlidis G, Kuroda J, Matsushima S, Sadoshima J, Tian R. Elimination of NADPH Oxidase Activity Promotes Reductive Stress and Sensitizes the Heart to Ischemic Injury.J Am Heart Assoc. 2014 Jan 27;3(1):e000555. PMID: 24470522. DOI: 10.1161/JAHA.113.000555.

2013

Khan RS, Lin Y, Hu Y, Son NH, Bharadwaj KG, Palacios C, Chokshi A, Ji R, Yu S, Homma S, Schulze PC, Tian R, Goldberg IJ. Rescue of Heart Lipoprotein Lipase-Knockout Mice Confirms a Role for Triglyceride in Optimal Heart Metabolism and Function. Am J Physiol Endocrinol Metab. 2013 Dec;305(11): E1339-47. PMID: 24085031. DOI: 10.1152/ajpendo.00349.2013.
Dai DF, Hsieh EJ, Chen T, Menendez LG, Basisty NB, Tsai L, Beyer RP, Crispin DA, Shulman NJ, Szeto HH, Tian R, Maccoss MJ, Rabinovitch PS. Global Proteomics and Pathway Analysis of Pressure-Overload-Induced Heart Failure and Its Attenuation by Mitochondrial-Targeted Peptides. Circ Heart Fail. 2013 Sep 1;6(5):1067-76. PMID: 23935006. DOI: 10.1161/CIRCHEARTFAILURE.113.000406.
Kolwicz Jr. SC, Purohit S, Tian R. Cardiac Metabolism and its Interactions with Contraction, Growth, and Survival of Cardiomyocytes. Circ Res. 2013 Aug 16;113(5):603-16. PMID: 23948585. DOI: 10.1161/CIRCRESAHA.113.302095.
Karamanlidis G, Lee CF, Garcia-Menendez L, Kolwicz Jr. SC, Suthammarak W, Gong G, Sedensky MM, Morgan PG, Wang W, Tian R. Mitochondria Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure. Cell Metab. 2013 Aug 6;18(2):239-50. PMID: 23931755. DOI: 10.1016/j.cmet.2013.07.002.
Garcia Menendez L, Karamanlidis G, Kolwicz SC Jr, Tian R. Substrain Specific Response to Cardiac Pressure Over load in C57BL/6 Mice. Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H397-402. PMID: 23709599. DOI: 10.1152/ajpheart.00088.2013.
Nowakowski SG, Kolwicz SC, Korte FS, Luo Z, Robinson-Hamm JN, Page JL, Brozovich F, Weiss RS, Tian R, Murry CE, Regnier M. Transgenic Overexpression of Ribonucleotide Reductase Improves Cardiac Performance. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6187-92. PMID 23530224. DOI: 10.1073/pnas.1220693110.
Marney LC, Kolwicz, Jr. SC, Tian R, Synovec RE. Sample Preparation Methodology for Mouse Heart Metabolomics Using Comprehensive Two-Dimensional Gas Chromatography Coupled With Time-Of-Flight Mass Spectrometry. Talanta. 2013 Apr 15;108:123-30. PMID: 23601879. DOI: 10.1016/j.talanta.2013.03.005.
Matsushima S, Kuroda J, Ago T, Zhai P, Ikeda Y, Oka S, Fong GH, Tian R, Sadoshima J. Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of Hypoxia-Inducible factor-1α and Upregulation of Peroxisome Proliferator-Activated Receptor-α. Circ Res. 2013 Apr 12;112(8):1135-49. PMID: 23476056. DOI: 10.1161/CIRCRESAHA.111.300171.

2012

Kim M, Tian R. Transcript Variant Dictates Prkag2 Cardiomyopathy? J Mol Cell Cardiol. 2012 Sep;53(3):317-9. PMID: 22789965 DOI: 10.1016/j.yjmcc.2012.06.015.
Kolwicz, Jr. SC, Olson DP, Marney LC, Garcia-Menendez L, Synovec RE, Tian R. Cardiac-specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy. Circ Res 2012, Aug 31;111(6): 728-38. PMID: 22730442. DOI: 10.1161/CIRCRESAHA.112.268128.
Kim M, Shen M, Ngoy S, Karamanlidis G, Liao R, Tian R. AMPK Isoform Expression in the Normal and Failing Hearts. J Mol Cell Cardiol. 2012 May;52(5):1066-73. PMID: 22314372. DOI: 10.1016/j.yjmcc.2012.01.016.
Yoshioka J, Chutkow WA, Lee S, Kim JB, Yan J, Tian R, Lindsey ML, Feener EP, Seidman CE, Seidman JG, Lee RT. Deletion of Thioredoxin-Interacting Protein in Mice Impairs Mitochondrial Function but Protects the Myocardium From Ischemia-Reperfusion Injury. J Clin Invest. 2012 Jan;122(1):267-79. PMID: 22201682. DOI: 10.1172/JCI44927.

2011

Karamanlidis G, Bautista-Hernandez V, Fynn-Thompson F, Del Nido P, Tian R. Impaired Mitochondrial Biogenesis Precedes Heart Failure in Right Ventricular Hypertrophy in Congenital Heart Disease. Circ Heart Fail. 2011 Nov;4(6):707-13. PMID: 21840936. DOI: 10.1161/CIRCHEARTFAILURE.111.961474.
Dzeja PP, Hoyer K, Tian R, Zhang S, Nemutlu E, Spindler M, Ingwall JS. Rearrangement of Energetic and Substrate Utilization Networks Compensate for Chronic Myocardial Creatine Kinase Deficiency. J Physiol. 2011 Nov 1;589(Pt 21):5193-211. PMID: 21878522. DOI: 10.1113/jphysiol.2011.212829.
Kim M, Tian R. Targeting AMPK for Cardiac Protection: Opportunities and Challenges. J Mol Cell Cardiol. 2011 Oct;51(4):548-53. PMID: 21147121. DOI: 10.1016/j.yjmcc.2010.12.004.
Xie Z, Lau K, Eby B, Lozano P, He C, Pennington B, Li H, Rathi S, Dong Y, Tian R, Kem D, Zou MH. Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice. Diabetes. 2011 Jun;60(6):1770-8. PMID: 21562078. DOI: 10.2337/db10-0351.
Kolwicz SC Jr, Tian R. Glucose Metabolism and Cardiac Hypertrophy. Cardiovasc Res. 2011 May 1;90(2):194-201. PMID:21502371. DOI: 10.1093/cvr/cvr071.
Pinz I, Tian R, Belke D, Swanson E, Dillmann W, Ingwall JS. Compromised Myocardial Energetics in Hypertrophied Mouse Hearts Diminish the Beneficial Effect of Overexpressing SERCA2a. J Biol Chem. 2011 Mar 25;286(12):10163-8. PMID: 21278384. DOI: 10.1074/jbc.M110.210757.

Prior to 2010

Force T, Bonow RO, Houser SR, Solaro RJ, Hershberger RE, Adhikari B, Anderson ME, Boineau R, Byrne BJ, Cappola TP, Kalluri R, LeWinter MM, Maron MS, Molkentin JD, Ommen SR, Regnier M, Tang WHW, Tian R, Konstam MA, Maron BJ, Seidman CE. Research Priorities in Hypertrophic Cardiomyopathy: Report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation. 2010 Sep 14;122(11):1130-3. PMID: 20837938. DOI: 10.1161/CIRCULATIONAHA.110.950089.
Kolwicz SC Jr, Tian R. Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy. J Vis Exp. 2010 Aug 31;(42):2069. PMID: 20834220. DOI: 10.3791/2069.
Karamanlidis G, Nascimben L, Couper GS, Shekar PS, Tian R. Defective DNA Replication Impairs Mitochondrial Biogenesis in Human Failing Hearts. Circ Res. 2010 May 14;106(9):1541-8. PMID: 20339121. DOI: 10.1161/CIRCRESAHA.109.212753.
Kolwicz SC, Tian R. Metabolic Therapy at the Crossroad: How to Optimize Myocardial Substrate Utilization? Trends Cardiovasc Med. 2009 Aug;19(6):201-7. PMID: 20211436. DOI: 10.1016/j.tcm.2009.12.005.
Wang Y, Tao L, Yuan Y, Lau WB, Li R, Lopez BL, Christopher TA, Tian R, Ma XL. Cardioprotective Effect of Adiponectin Is Partially Mediated by Its AMPK-independent Antinitrative Action.Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E384-91. PMID: 19470831. DOI: 10.1152/ajpendo.90975.2008.
Folmes C, Wagg C, Shen M, Clanachan A, Tian R, and Lopaschuk, GD. Suppression of 5′-AMP-activated Protein Kinase Activity Does Not Impair Recovery of Contractile Function During Reperfusion of Ischemic Hearts. Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H313-21. PMID: 19429810. DOI: 10.1152/ajpheart.01298.2008.
Yan J, Young ME, Cui L, Lopaschuk GD, Liao R, Tian R. Increased Glucose Uptake and Oxidation in Mouse Hearts Prevent High Fatty Acid Oxidation but Cause Cardiac Dysfunction in Diet-Induced Obesity. Circulation. 2009 Jun 2;119(21):2818-28. PMID: 19451348. DOI: 10.1161/CIRCULATIONAHA.108.832915.
Wang Y, Gao E, Tao L, Lau WB, Yuan Y, Goldstein BJ, Lopez BL, Christopher TA, Tian R, Koch WJ, Ma XL. AMP-activated Protein Kinase Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but Has Minimal Effect on the Antioxidant/Antinitrative Protection of Adiponectin. Circulation. 2009 Feb 17;119(6):835-44. PMID: 19188503. DOI: 10.1161/CIRCULATIONAHA.108.815043.
Gundewar S, Calvert JW, Jha S, Toedt-Pingel I, Ji SY, Nunez D, Ramachandran A, Mauricio Anaya-Cisneros M, Tian R, Lefer DJ. Activation of AMP-activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure. Circ Res. 2009 Feb 13;104(3):403-11. PMID: 19096023. DOI: 10.1161/CIRCRESAHA.108.190918.
Tian R, Ingwall JS. How Does Folic Acid Cure Heart Attacks? Circulation. 2008 Apr 8;117(14):1772-4. PMID: 18391119. DOI: 10.1161/CIRCULATIONAHA.108.766105.
Calvert JW, Gundewar S, Jha S, Greer JJ, Bestermann, Tian R, Lefer DJ. Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction via AMPK-eNOS-mediated Signaling. Diabetes. 2008 Mar;57(3):696-705. PMID: 18083782. DOI: 10.2337/db07-1098.