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The Isoherranen lab is located in the Department of Pharmaceutics in the School of Pharmacy. Our lab uses basic enzyme kinetic, biochemical, bioanalytical and pharmacokinetic methods to study drug and vitamin disposition and changes in drug therapy and vitamin disposition in different physiological and disease states. Our research projects are highly translational and we extend out basic research findings to clinical importance. The three main research areas in the lab entail characterization of vitamin A metabolism and the processes that regulate cell and tissue concentrations of retinoic acid the active metabolite of vitamin A, evaluation of drug disposition during pregnancy and fetal exposure and effects of xenobiotics, and methods of in vitro to in vivo prediction, simulation and rationalization of drug-drug and drug-disease interactions. We are also actively involved in collaborations with the University of Washington and with investigators in other US institutions.