Selected List of Publications
Fortilin Is an Anti-apoptotic Molecule
Characterization of fortilin, a novel anti-apoptotic protein. Journal of Biological Chemistry 2001; 276(50): 47542–49. PMID: 11598139
Li F, Zhang D, and Fujise K
Fortilin-deficiency causes embryonic lethality through the overactivation of BMP4 pathway. Biochimica et Biophysica Acta 2009; 1790: 326–38. PMID: 2695948
Koide Y, Tonganunt M, Kato Y, and Fujise K
Elevation of serum fortilin levels is specific for apoptosis and signifies cell death in vivo. Biochimica et Biophysica Acta Clinical 2014; 2: 103–11. PMID: 25558477
Sinthujaroen P, Wanachottrakul N, Pinkaew D, Petersen JR, Phongdara A, Sheffield-Moore M, and Fujise K
Fortilin, a Multifunctional Protein, Interacts and Modulates Molecules That Controls Apoptosis, Cell Cycles, ROS handling—p53, PRX1, MCL1, and Ca2+
The physical and functional antagonism between p53 and fortilin, an anti-apoptotic molecule. Journal of Biological Chemistry 2011; 286: 32575–85.
Chen Y, Fujita T, Zhang D, Doan H, Pinkaew D, Liu Z, Wu J, Koide Y, Chiu A, Jun-Lin C, Chang JY, Ruan KH, and Fujise, K:
Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protect against alcohol-induced liver damage in mice. Scientific Reports 2016; 6:18701
Chattopadhyay A, Pinkaew D, Doan HQ, Jacob RB, Verma SK, Friedman H, Peterson AC, Kuyumcu-Martinez MN, McDougal OM, and Fujise K
Physical and functional interaction between MCL1 and fortilin. The potential role of MCL1 as a fortilin chaperone. Journal of Biological Chemistry 2002; 227 (40): 37430–38. PMID: 12149273
Zhang D, Li F, Mnjoyan ZH, Weidner D, and Fujise K
Antiapoptotic protein partners fortilin and MCL1 independently protect cells from 5-FU-induced cytotoxicity: Fortilin-MCL1 interaction in apoptosis. Journal of Biological Chemistry 2004; 279: 40868–75. PMID: 15262975
Graidist P, Phongdara A, and Fujise K
Fortilin binds Ca2+ and blocks Ca2+-dependent apoptosis in vivo. Biochemical Journal 2007; 408(2): 181–91. PMCID: PMC2267342
Graidist P, Yazawa M, Tonganunt M, Nakatomi A, Lin CC, Chang J, Phongdara A, and Fujise K
Fortilin Facilitates Atherosclerosis
Fortilin reduces apoptosis in macrophages and promotes atherosclerosis. American Journal of Physiology (Heart and Circulatory Physiology) 2013; 305: H1519–29.
Pinkaew D, Le RJ, Eltorky M, Teng BB, and Fujise K
Fortilin Protects the Liver Against Acute Alcohol Injury
Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protect against alcohol-induced liver damage in mice. Scientific Reports 2016; 6:18701
Chattopadhyay A, Pinkaew D, Doan HQ, Jacob RB, Verma SK, Friedman H, Peterson AC, Kuyumcu-Martinez MN, McDougal OM, and Fujise K
Fortilin Sustains Cardiomyocyte Survival
Fortilin inhibits p53, halts cardiomyocyte apoptosis, and protects the heart against heart failure. Cell Death Discovery 2021; 7:310. PMID: 34689154
Chunhacha P, Pinkaew D, Sinthujaroen P, Bowles ED, and Fujise K
Fortilin binds TGF-β1 and blocks the activation of the TGF-β pathway
Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation. Communications Biology 2022; 5:157. PMID: PENDING
Pinkaew D, Erik Martinez-Hackert E, Jia W, King MD, Miao F, Enger NR, Silakit R, Ramana K, Chen SY, and Fujise K