Schindler Iterative Translation Lab

 

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We are interested in trauma and its comorbidities (e.g. affective disorders, addiction, metabolic dysfunction, neurodegeneration). Using an iterative translation approach, we utilize both human and animal populations and focus on reciprocal connections between the brain and peripheral organs (e.g. liver, gut) in order to understand adverse outcomes of trauma from a holistic systems biology standpoint. We are especially interested in understanding the role of monoamines (e.g. dopamine, serotonin) and neuromodulators (e.g. opioids, cytokines). We utilize computational medicine approaches (e.g. machine learning, big data, electronic medical records, biomarkers) and are committed to open source science.

Current Projects:

Causal mechanism and therapeutic potential of the dynorphin/kappa opioid receptor system in blast-induced psychopathology

Exploring the role of the gut microbiome in the development of psychiatric outcomes following blast polytrauma

Mapping individual differences in the polytrauma clinical triad to substance use risk: a pilot study

Neural Mechanisms of Impulsivity and Attention Following Traumatic Brain Injury

Trauma Alcohol and Aging

Understanding Chronic Health Outcomes and COVID-19 Risk Among OEF/OIF/OND Veterans

Utilizing Vital Signs to Predict Efficacy of Vagal Nerve Stimulation in Treating Behavioral and Autonomic Nervous System Changes Following Blast Traumatic Brain Injuries