Differentiating Kidney Organoids: Human podocytes (red) surrounded by proximal tubule (purple) starting to form a neoglomerulus and becoming inosculated by vasculature from the mouse (green). (Credit: Thomas Vincent)
We are currently working with the Freedman Lab to explore the use of porous templated scaffolds for kidney regeneration. The Freedman lab specializes in kidney organoid differentiation from induced pluripotent stem cells. This process takes around 21 days and the kidney organoids display nephron components such as podocytes and tubular epithelial cells. These organoids can be implanted into mice to see how they mature. We hope to show that when combined with the scaffolds from the Ratner lab, they will result in improved vascularization and integration.
Keywords: kidney, regeneration, stem cells, organoid, precision porous
Active Researcher(s): Thomas Vincent