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Email: annagill@uw.edu
LAB MEMBERS
PUBLICATIONS |
ASSISTANT PROFESSOR Research Focus: Neural mechanisms of memory impairment in aging and Alzheimer’s disease
RESEARCH The Gillespie lab strives to understand how the neural mechanisms underlying memory processes degrade over the course of healthy aging and in the context of neurodegenerative disease. The lab uses in vivo electrophysiology to record simultaneously from hundreds of neurons from rats as they learn and perform complex memory-dependent tasks. By using advanced computational methods to capture how neuronal ensembles represent and store experiences as memories, we can identify changes in these mechanisms and relate them to age- or Alzheimer’s-related memory impairment. We are working to develop novel interventional tools to prevent or reduce detrimental changes in neural activity and preserve cognitive ability over the lifespan.
FEATURED PUBLICATIONS Gillespie AK, Astudillo Maya DA, Denovellis EL, Desse S, Frank LM. Neurofeedback training can modulate task-relevant memory replay in rats. bioRxiv, Oct 17 2022 (preprint) Joshi A, Denovellis EL, Mankili A, Meneksedag Y, Davidson TJ, Gillespie AK, Guidera JA, Roumis DK, Frank LM. Dynamic synchronization between hippocampal spatial representations and the stepping rhythm. bioRxiv, Feb 25 2022 (preprint) Gillespie AK, Astudillo Maya DA, Denovellis EL, Liu DF, Kastner DB, Coulter ME, Roumis DK, Eden UT, Frank LM. Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice. Neuron, 109(19):3149-3163. Oct 6, 2021 Denovellis EL, Gillespie AK, Coulter ME, Sosa M, Chung JE, Eden UT, Frank LM. Hippocampal replay of experience at real-world speeds. eLife, 10:e64505, Sept 27, 2021 Jones EA, Gillespie AK, Yoon SY, Frank LM, Huang Y. Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer’s Disease Mouse Model. Cell Reports, 29(8):2123-2133.e4 Nov. 19, 2019 Gillespie AK, Jones EA, Lin YH, Karlsson MP, Kay K, Yoon SY, Tong LM, Nova P, Carr JS, Frank LM, Huang Y. Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations During Hippocampal Sharp-wave Ripples. Neuron, 90(4): 740-51, May 18, 2016 |
