ZHIWEN YE, PhD

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PUBLICATIONS

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ACTING ASSISTANT PROFESSOR

Steinmetz Lab (Steinmetz Lab Website)
Research Focus: Brain dynamics and Neuropixels

RESEARCH

I work with Dr. Nick Steinmetz on brain-wide neural dynamics underlying behavior, as well as exploring new design of Neuropixels probes with higher site density. (1) We use large scale recording methods, including widefield calcium imaging and Neuropixels recordings, to investigate coordinated neural activity and dynamic patterns across brain areas. We also use simultaneous optogenetics to disentangle the contribution of different neural components. (2) Neuropixels 1.0 and 2.0 probes have enabled the recording of unprecedented large populations of neurons. A new probe design, called Neuropixels Ultra, with recording sites at 6 micrometer isotropic pitch, helps to explore the possibility of unbiased sampling, spike sorting stability and cell type identification of extracellular electrophysiology data. Before joining the Steinmetz lab, my research included whole-brain neural connectivity with rabies virus tracing and electrophysiological studies of sleep/wake regulation.

SELECTED PUBLICATIONS

Ye Z, Yu X, Houston CM, Aboukhalil Z, Franks NP, Wisden W, Brickley SG (2017). Fast and slow inhibition in the visual thalamus is influenced by allocating GABAA receptors with different g subunits. Front Cell Neurosci 11:95.

Jager P*, Ye Z*, Yu X, Zagoraiou L, Prekop HT, Partanen J, Jessell TM, Wisden W, Brickley SG, Delogu A. (2016). Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus. Nat Commun. 7:13579.

Uygun DS*, Ye Z*, Zecharia AY, Harding EC, Yu X, Yustos R, Vyssotski AL, Brickley SG, Franks NP, Wisden W. (2016). Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons. J Neurosci. 36(44):11171-11184.

Yu X*, Ye Z*, Houston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden W. (2015) Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron, 87(1), 164-178.

Ye Z, McGee TP, Houston CM, Brickley SG. (2013) The contribution of delta subunit-containing GABAA receptors to phasic and tonic conductance changes in cerebellum, thalamus and neocortex. Front Neural Circuits, 7, 203.