Vaccine Makers Are Preparing for Bird Flu

Although most experts say bird flu is not an immediate threat to humans, efforts are underway to produce vaccines for H5N1 or another potential pandemic virus.

“RNA vaccines can be designed extremely quickly—you only need the genetic sequence of what the new variant is that’s emerging, and within weeks, [you] can have a vaccine already tested in animal models,” Fuller says.

Read more in the Scientific American

An mRNA vaccine with a twist—it copies itself—protects against COVID-19

Fuller says a self-amplifying mRNA COVID-19 vaccine ideally would replace the two primary doses, giving it an even clearer benefit over its conventional relatives. A booster months later might still be warranted, as is encouraged now for the current mRNA vaccines. But self-amplifying mRNAs could also lead to more durable immune responses, Fuller suggests.

Read more in Science.

COVID-19: The Omicron Variant

If the omicron variant of the coronavirus is different enough from the original variant, it’s possible that existing vaccines won’t be as effective as they have been. If so, it’s likely that companies will need to update their vaccines to better fight omicron. Deborah Fuller is a microbiologist who has been studying mRNA and DNA vaccines for over two decades. Here she explains why vaccines might need to be updated and what that process would look like.

Read more in the The Conversation and the Seattle Times.