An mRNA vaccine with a twist—it copies itself—protects against COVID-19

Fuller says a self-amplifying mRNA COVID-19 vaccine ideally would replace the two primary doses, giving it an even clearer benefit over its conventional relatives. A booster months later might still be warranted, as is encouraged now for the current mRNA vaccines. But self-amplifying mRNAs could also lead to more durable immune responses, Fuller suggests.

Read more in Science.

COVID-19: The Omicron Variant

If the omicron variant of the coronavirus is different enough from the original variant, it’s possible that existing vaccines won’t be as effective as they have been. If so, it’s likely that companies will need to update their vaccines to better fight omicron. Deborah Fuller is a microbiologist who has been studying mRNA and DNA vaccines for over two decades. Here she explains why vaccines might need to be updated and what that process would look like.

Read more in the The Conversation and the Seattle Times.

‘It’s like a war:’ Health experts stress getting both shots to combat Delta variant

A new study on the fast-moving Delta variant is revealing the importance of getting both vaccine shots.

Local health experts said they are especially concerned the variant can partly evade the immune system. Health experts said it’s like going to battle, without all your armor.

“Between our immune system and the virus, it’s like a war,” said UW Medicine Microbiologist, Dr. Deborah Fuller.

Read more from Dr. Fuller on KOMO News here.

Double-dipping? Mix and match? What future may hold for COVID-19 vaccinations

A pairing of two different types of vaccines will probably be more effective than a combination of two different vaccines that use the same basic strategy, Fuller says. “We think that…some are just better at triggering certain arms of the immune system than others,” she says. “And when you have them in combination, they start to synergize and leverage all of our defenses.” 

Read more from Dr. Fuller in the Seattle Times and Popular Science.