Student Program: M3D PhD Program

Research Interests

Immuno-oncology, T-cell immunology

First-Year Rotations (2021-2022)

Autumn: William Grady, MD 

Winter: Edus “Hootie” Warren, MD, PhD 

Spring: Evan Newell, PhD 

Research Interests

T cell immunology, gamma delta T cells, host responses to mycobacterial infection

Publications

Tappen T, Layton E, Maerz M, Bishop E, Scriba TJ, Seshadri C. ”Molecular requirements for αβ and γδ T cell receptor recognition of mycobacterial phosphomycoketide” PacTB Conference; 2023 April; Berkeley, CA. Invited oral presentation.

Honaker Y, Hubbard N, Xiang Y, Fisher L, Hagin D, Sommer K, Song Y, Jung Yang S, Lopez C, Tappen T, Dam E, Khan I, Hale M, Buckner J, Scharenberg A, Torgerson T, Rawlings D. Gene Editing to Induce FOXP3 Expression in Human CD4 + T Cells Leads to a Stable Regulatory Phenotype and Function. Science Translational Medicine Vol 12.; 2020

Yang S, Singh A, Drow T, Tappen T, Honaker Y, Barahmand-Pour-Whitman F, Linsley P, Cerosaletti K, Mauk K, Xiang Y, Smith J, Mortensen E, Cook P, Sommer K, Khan I, Liggitt D, Rawlings D, Buckner J. Pancreatic Islet-Specific Engineered T Regs Exhibit Robust Antigen-Specific and Bystander Immune Suppression in Type 1 Diabetes Models. Science Translational Medicine Vol 14.; 2022.

Other

Treasurer of Husky Science Communication Initiative (HuSCI)

First-Year Rotations (2021-2022)

Autumn: Thomas R. Hawn, MD, PhD 

Winter: Martin Prlic, PhD

Spring: Chetan Seshadri, MD

Research Focus

Vaccine development, antibody technologies, gene editing, autoimmunity

Research Interests

Gut Microbiome, Community Interactions, role of gut microbiome/metabolome implications in human health

Other

Director of Husky Science Communication Initiative (HuSCI) https://husciorg.wixsite.com/husci 

First-Year Rotations (2021-2022)

Autumn: Thomas Reh, PhD

Winter: Manu Setty, PhD

Spring: Andrew Stergachis, MD, PhD 

Research Interests

Gene Therapy

Publications

Gottimukkala, K.S.V., Lane, D.D., Cunningham, R.A., Jwa, Y., Adair, J.E. Development of gold nanoparticles for in vivo CRISPR delivery: improving nuclease loading and stability with pre- formed RNP complexes – Oral Presentation at American Society of Gene and Cell Therapy – May 2023 – Los Angeles.

Shahbazi, R., Lane, D.D., Lipson, P., Gottimmukkala, K.S.V., Cunningham, R., Adair, J.E. Hematopoietic stem and progenitor cell specific antibodies and intraosseous administration enhance delivery of a CRISPR nanoformulation – American Society of Gene and Cell Therapy – May 2023 – Los Angeles.

Cassidy, M.E.*, Gottimukkala, K.S.V.*, Lane, D.D., Jwa, Y., Adair, J.E. Human 𝛃-2-microglobulin (B2M) knockdown as an in vitro model to evaluate CRISPR delivery. [In preparation, abstract presentation at 2023 annual meeting of the American Society of Gene and Cell Therapy. *Co- first authors, May 2023 – American Society of Gene and Cell Therapy – May 2023 – Los Angeles.

Shahbazi, R., Lipson, P., Gottimukkala, K.S.V., Lane, D.D., Adair, J.E. (2023). CRISPR Gene Editing of Hematopoietic Stem and Progenitor Cells. In: Pelus, L.M., Hoggatt, J. (eds) Hematopoietic Stem Cells. Methods in Molecular Biology, vol 2567. Humana, New York, NY.

Karthikeya Gottimukkala and Adair Lab members at ASGCT 26th Annual meeting in Los Angeles – May 2023.

First-Year Rotations (2021-2022)

Autumn: Michael Haffner, MD, PhD

Winter: Scott Furlan, MD 

Spring: Steven Henikoff, PhD