2023
Singh, S.K; Reyna, A.; Xie, X.; Mao, H.; Ji, M.; Zheng, N.; Hsu, P.L.; Chatterjee, C. Total chemical synthesis of sumoylated histone H4 reveals negative biochemical crosstalk with histone ubiquitylation. RSC Chemical Communications 2023.
2022
Chatterjee, C and Singh, S.K. Peptide and protein chemistry approaches to study the tumor suppressor protein p53. RSC Organic & Biomolecular Chemistry 2022.
2021
Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts. eLife 2021.
Guido V. Janssen; Susan Zhang; Remco Merkx; Christa Schiesswohl; Champak Chatterjee; K. Heran Darwin; Paul P. Geurink; Huib Ovaa; Gerbrand J. van der Heden van Noort Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System. ChemBioChem 2021.
Witus, S.R.; Burrell, A.L.; Farrell, D.P.; Kang, J.; Wang, M.; Hansen, J.M.; Pravat, A.; Tuttle, L.M.; Brzovic, P.S.; Chatterjee, C.; Zhao, W.; DiMaio, F.; Kollman, J.M.; Klevit, R.E. BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1. Nat. Struct. Mol. Bol. 2021.
Liu. Y.; Ma, C.; Leonen, C. J. A.; Chatterjee, C.; Nováková, G.; Marek, A.; Tureček, F. Tackling a Curious Case: Generation of Charge-Tagged Guanosine Radicals by Electron Transfer in the Gas Phase and Characterization by UV-Vis Photodissociation Action Spectroscopy and Theory. J. Am. Soc. Mass Spec. 2021.
2020
Weller, C..; Chatterjee, C. Facile peptide ubiquitylation with the ligation auxiliary 2-aminooxyethanethiol. Methods Mol. Biol. 2020, 2133, 293-312.
Chatterjee, C. Chapter 23: Histone synthesis. in Total Chemical Synthesis of Proteins. Brik, Dawson and Liu eds. 2020. in press.
Buckle, E.L.; Sampath, J.; Michael, N.; Whedon, S.D.; Leonen, C.J.A.; Pfaendtner, J.; Drobny, G.; Chatterjee, C. Trimethylation of the silica-precipitating peptide R5 leads to increased silica nanoparticle size. ChemBioChem 2020, https://doi.org/10.1002/cbic.202000264.
Dhall, A.; Shelton, P.M.M.; Delachat, A. M.-F.; Leonen, C.J.A.; Fierz, B.; Chatterjee, C. Sequence-independent DNA-binding by the lysine specific demethylase 1 (LSD1) enzyme enables nucleosome demethylation. Biochemistry 2020, https://doi.org/10.1021/acs.biochem.0c00412.
2019
; , R.; , C.; , C.; , K.H.; Ovaa, H. Discovery and Optimization of Inhibitors for the Pup Proteasome System in Mycobacterium tuberculosis. BioRxiv https://www.biorxiv.org/content/10.1101/796359v1.full (posted October 7th).
Whedon, S.D; Parker, M.K.; Tyson, E.L.; Ritterhoff, T.; Shelton, P.M.M.; Chatterjee, C. A clickable glutamine (CliQ) derivative for the traceless reversible modification of peptides and proteins. RSC ChemComm 2019, 55, 2043-2045.
2018
Hsu, P.L; Li, H.; Lau, H.-T.; Leonen, C.; Dhall, A.; Ong, S.-E.; Chatterjee, C; Zheng, N. Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. Cell 2018, 174, 1-11.
Stewart, M.D.; Zelin, E.; Dhall, A.; Walsh, T.; Upadhyay, E.; Corn, J.E.; Chatterjee, C.; King, M.-C.; Klevit, R.E. BARD1 is necessary for ubiquitylation of nucleosomal histone H2A and for transcriptional regulation of estrogen metabolism genes. Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 1316-1321
Leonen, C.L.; Upadhyay, E.; Chatterjee, C. Studies of biochemical crosstalk in chromatin with semisynthetic histones. Curr. Opin. Chem. Biol. 2018 (Special Issue on Chemical Epigenetics)
2017
Sivanesam, K.; Kier, B.L.; Whedon, S.D.; Chatterjee, C.; Andersen, N.H. Biological consequences of improving the structural stability of hairpins that have antimicrobial activity. J. Pept. Sci. 2017, 23, 899-906.
Dhall, A.; Weller, C. E.; Chu, A.; Shelton, P.M.M.; Chatterjee, C. Chemically sumoylated histone H4 stimulates intranucleosomal demethylation by the LSD1-CoREST complex. ACS Chemical Biology 2017, 12, 2275-2280.
Shelton, P.M.M.; Weller, C. E.; Chatterjee, C. A facile N-mercaptoethoxyglycinamide (MEGA) linker approach to peptide thioesterification and cyclization. J. Am. Chem. Soc. 2017, Feb 23. doi: 10.1021/jacs.6b13271.
2016
Sivanesam, K.; Kier, B.L.; Whedon, S.D., Chatterjee, C.; Andersen, N.H. Hairpin structure stability plays a role in the activity of two antimicrobial peptides. FEBS Lett. 2016, 590, 4480-4488.
Whedon, S. D.; Nagula, M.; Rana, A.; Senger, N. A.; Weller, C. E.; Tureček, F.; Strieter, E.; Chatterjee, C. Selenocysteine as a latent bioorthogonal electrophilic probe for deubiquitylating enzymes. J. Am. Chem. Soc. 2016, 138, 13774–13777.
Weller, C. E.; Dhall, A.; Ding, F.; Linares, E.; Whedon, S. D.; Senger, N. A.; Tyson, E. A.; Bagert, J. D.; Li, X.; Augusto, O.; Chatterjee, C. Aromatic thiol-mediated cleavage of N-O bonds enables chemical ubiquitylation of folded proteins. Nat. Commun. 2016, 7:12979, DOI: 10.1038/ncomms12979
Ling, H.; Lim, K.S.; Kim, H.; Hinds, T.R.; Jo, U.; Mao, H.; Weller, C.E.; Sun, J.; Chatterjee, C.; D’Andrea, A.D.; Zheng, N. Allosteric activation of ubiquitin-specific proteases by β-propeller proteins UAF1 and WDR20. Mol. Cell. 2016, 63, 249-60.
Dhall, A.; Weller, C.E.; Chatterjee, C. Rapid semisynthesis of acetylated and sumoylated histone analogs. Methods Enzymol. 2016, 574, 149-65 (Ronen Marmorstein, Ed.).
2015
Weller, C.E.*; Chatterjee, C.* (co-authors) All about that amide bond: the 6th Chemical Protein Synthesis Meeting. ChemBioChem 2015, 16, 2531-2536.
Eustis, I.; Huang, J.; Pilkerton, M.E.; Chatterjee, C. A time-resolved FRET assay to measure activity of the deamidase of the prokaryotic ubiquitin-like protein. Anal. Biochem. 2015, 487, 27-29.
Jastrab, J.B.; Wang, T.; Murphy, J.P.; Bai, L.; Hu, K.; Merkx, R.; Huang, J.; Chatterjee, C.; Ovaa, H.; Gygi, S.P.; Li, H.; Darwin, K.H. An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2015, 112, E1763-E1772.
2014
Dhall, A.; Wei, S.; Fierz, B.; Woodcock, C.; Lee, T.-H.; Chatterjee, C. Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions. J. Biol. Chem. 2014, DOI: 10.1074/jbc.M114.591644.
Dhall, A.; Chatterjee, C. “Chapter 8: Chemical and genetic approaches to studying histone modifications” in Epigenetic Technological Applications, Y. George Zheng Ed., Elsevier Press.
Weller. C.E.; Huang, W.; Chatterjee, C. Facile synthesis of native and protease-resistant ubiquitylated peptides. ChemBioChem 2014, 15, 1263-1267.
Weller, C.E.; Pilkerton, M.E.; Chatterjee, C. Chemical strategies to understand the language of ubiquitin signaling. Biopolymers 2014, 101, 144-155.
2013
Smirnov, D.; Dhall, A.; Sivanesam, K.; Sharar, R.J.; Chatterjee, C. Fluorescent probes reveal a minimal ligase recognition motif in the prokaryotic ubiquitin-like protein from Mycobacterium tuberculosis. J. Am. Chem. Soc. 2013, 135, 2887-2890.
2012
Meier, F.; Abeywardana, T.; Dhall, A.; Marotta, N.P.; Varkey, J.; Langen, R.; Chatterjee, C.; Pratt, M. R. Semisynthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation. J. Am. Chem. Soc. 2012, 134, 5468-5471.
2011
Dhall, A.; Chatterjee, C. Chemical approaches to understand the language of histone modifications ACS Chem. Biol. 2011, 6, 987-999.
Fierz, B.; Chatterjee, C.; McGinty, R.K.; Bar-Dagan, M.; Raleigh, D.P.; Muir, T.W.Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction Nat. Chem. Biol. 2011, 7, 113-119.
2010
Chatterjee, C.; McGinty, R.K.; Fierz, B.; Muir, T.W. Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation Nat. Chem. Biol. 2010, 6, 267-269.
Chatterjee, C.; Muir, T. W. Chemical approaches for studying histone modifications J. Biol. Chem. 2010, 285, 11045-11050.
2009
McGinty, R.K.; Kohn, M.; Chatterjee, C.; Chiang, K.P; Pratt, M.R.; Muirt, T.W. Structure activity analysis of semisynthetic nucleosomes: Mechanistic insights of the stimulation of Dot1L by ubiquitylated histone H2B ACS Chem. Biol. 2009, 4, 958-968.
McGinty, R.K.; Chatterjee, C.; Muir, T.W. Semisynthesis of ubiquitylated proteins Methods Enzymol. 2009, 462, 225-243.
Levengood, M.R.; Kerwood, C.C.; Chatterjee, C.; van der Donk, W.A. Investigations of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids ChemBioChem 2009, 10, 911-919.
2008
Miller, L.M.; Menthena, A.; Chatterjee, C.; Verdier-Pinard, P.; Novikoff, P. Horwitz, S.B.; Angeletti, R.H. Increased levels of a unique post-translationally modified bIVb-tubulin isotype in liver cancer Biochemistry 2008, 47, 7572-7582.
Furgerson Ihnken, L.A.; Chatterjee, C.; van der Donk, W.A. In vitro reconstitution and substrate specificity of a lantibiotic protease Biochemistry 2008, 47, 7352-7363.
Patton, G.C.; Paul, M.; Cooper, L.E.; Chatterjee, C.; van der Donk, W.A. The importance of the leader sequence for directing lanthionine formation in lacticin 481 Biochemistry 2008, 47, 7342-7351.
McGinty, R.K.; Kim, J.; Chatterjee, C.; Roeder, R.G.; Muir, T.W. Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation Nature 2008, 453, 812-816.
2007
Chatterjee, C.; McGinty, R.K.; Pellois, J.-P.; Muir, T.W. Auxiliary-mediated site-specific peptide ubiquitylation Angew. Chem. Int. Ed. Engl. 2007, 46, 2814-2818.
2006
Chatterjee, C.*; Patton, G.C.*; Cooper, L.; Paul, M.; van der Donk, W.A. Engineering dehydro amino acids and thioethers into peptides using Lacticin 481 synthetase Chemistry and Biology (Cell Press) 2006, 13, 1109-1117.
Miller, L.M.; Chatterjee, C.; van der Donk, W.A.; Kelleher, N.L. The dehydratase activity of Lacticin 481 synthetase is highly processive J. Am. Chem. Soc. 2006, 128, 1420-121.
2005
Chatterjee, C.; Paul, M.; Xie, L.; van der Donk, W.A. Biosynthesis and mode of action of lantibiotics Chem. Rev. 2005, 105, 633-683.
Chatterjee, C.; Miller, L.M.; Leung, Y.L.; Xie, L.; Yi, M.; Kelleher, N.L.; van der Donk, W.A. Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production J. Am. Chem. Soc. 2005, 127, 15332-15333.
2004
Xie, L.; Miller, L.M.; Chatterjee, C.; Averin, O.; Kelleher, N.L.; van der Donk, W.A. Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity Science 2004, 303, 679-681.
2002
Xie, L.; Chatterjee, C.; Balsara, R.; Okeley, N.M.; van der Donk, W.A. Heterologous expression and purification of SpaB involved in subtilin biosynthesis Biochem. Biophys. Res. Commun. 2002, 295, 952-957.