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2023
Forsyth, J.K., Bearden, C.E. (2023). Rethinking the First Episode of Schizophrenia: Identifying Convergent Mechanisms During Development and Moving Toward Prediction. American Journal of Psychiatry. [LINK]
2022
Kuo, S.S., Ventura, J., Forsyth, J.K., Subotnik, K.L., Turner, L.R., Nuechterlein, K.H. (2022). Developmental trajectories of premorbid functioning predict cognitive remediation treatment response in first-episode schizophrenia. Psychological Medicine. [LINK]
Jalbrzikowski, M., Lin, A., Vajdi, A., Grigoryan, V., Kushan, L., Ching, C. R. K., Hayes, R. A., Chu, S., Sugar, C., Forsyth, J. K., Bearden, C. E. (2022). Mapping longitudinal trajectories of cortical development in 22q11.2 copy number variants. Molecular Psychiatry. [LINK]
Sønderby, I. E., Ching, C. R. K., Thomopoulos, S. I., van der Meer, D., Sun, D., Forsyth, J. K., et al. ENIGMA 22q11.2 Deletion Syndrome Working Group. (2022). Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs. Human Brain Mapping, 43(1): 300-328. [LINK]
2021
Lin, A.*, Forsyth, J. K.*, Hoftman, G. D.*, Kushan-Wells, L., Jalbrzikowski, M., Dokuru, D., Coppola, G., Fiksinki, A., Zinstok, J., Vorstman, J., Nachun, D., Bearden, C. E. Ching, C. R. K., Villalon-Reina, J. E., 22q11.2 ENIGMA Consortium, Thompson, P. M., Bearden, C. E. (2021). Transcriptomic profiling of whole blood in 22q11.2 reciprocal copy number variants reveals that cell proportion highly impacts gene expression. Brain, Behavior, & Immunity – Health, 18, 100386 (*co-first author). [LINK]
Forsyth, J. K., Mennigen, E., Lin, A., Sun, D., Vajda, A., Kushan-Wells, L., Ching, C. R. K., Villalon-Reina, J. E., 22q11.2 ENIGMA Consortium, Thompson, P. M., Bearden, C. E. Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics. (2021). Cerebral Cortex, 31(7), 3285-3298. [LINK]
Cao, H., Chen, O. Y., McEwen, S. C., Forsyth, J. K., Gee, D. G., Bearden, C. E., Addington, J., Goodyear, B., Cadenhead, K. S., Mirzakhanian, H., Cornblatt, B. A., Carrion, R. E., Mathalon, D. H., McGlashan, T. H., Perkins, D. O., Belger, A., Thermenos, H., Tsuang, M. T., van Erp, T. G. M., Walker, E. F., Hamann, S., Anticevic, A., Woods, S. W., Cannon, T. D. (2021). Cross-paradigm connectivity: reliability, stability, and utility. Brain Imaging and Behavior, 15(2), 614-629. [LINK]
2020
Ching, C. R. K., Gutman, B. A., Sun, D., Villalón-Reina, J., Ragothaman, A., Isaev, D., Zavaliangos-Petropulu, A., Lin, A., Jonas, R. K., Kushan, L., Pacheco-Hansen, L., Vajdi, A., Forsyth, J. K., Jalbrzikowski, M., Bakker, G., van Amelsvoort, T., Antshel, K. M., Fremont, W., Kates, W. R., Campbell, L. E., McCabe, K. L., Craig, M.C, Daly, E., Gudbrandsen, M., Murphy, C. M., Murphy, D. G., Murphy, K. C., Fiksinski, A., Koops, S., Vorstman, J., Crowley, T. B., Emanuel, B. S., Gur, R. E, McDonald-McGinn, D. M., Roalf, D. R., Ruparel, K., Schmitt, J. E., Zackai, E. H., Durdle, C. A., Goodrich-Hunsaker, N. J., Simon, T. J., Bassett, A.S., Butcher, N. J., Chow, E. W.C., Vila-Rodriguez, F., Cunningham, A., Doherty, J., Linden, D. E., Moss, H., Owen, M. J., van den Bree, M., Crossley, N. A., Repetto, G. M., Thompson, P. M., Bearden, C. E. (2020). Mapping subcortical brain alterations in 22q11.2 Deletion Syndrome: Effects of deletion size and convergence with idiopathic neuropsychiatric illness. American Journal of Psychiatry, 177(7), 589-600. [LINK]
Forsyth, J. K., Nachun, D., Gandal, M. J., Geschwind, G., Anderson, A. E., Coppola, G., Bearden, C. E. (2020). Synaptic and gene regulatory mechanisms in schizophrenia, autism, and 22q11.2 copy number variant-mediated risk for neuropsychiatric disorders. Biological Psychiatry, 87(2), 150-163. [LINK]
Villalón-Reina, J. E., Martinez, K., Qu, X., Ching, C., Nir, T. M., Kothapalli, D., Corbin, C., Sun, D., Lin, A., Forsyth, J. K., Kushan, L., Vajdi, A., Jalbrzikowski, M., Hansen, L., Jonas, R. K., van Amelsvoort, T., Bakker, G., Kates, W. R., Antshel, K. M., Fremont, W., Campbell, L. E., McCabe, K. L., Daly, E., Gudbrandsen, M., Murphy, C., Murphy, D., Craig, M., Emanuel, B., McDonald-McGinn, D., Vorstman, J., Fiksinski, A., Koops, S., Ruparel, K., Roalf, D., Gur, R. R., Schmitt, J. E., Simon, T. J., Goodrich-Hunsaker, N. J., Durdle, C. A., Doherty, J., Cunningham, A. C., van den Bree, M., Linden, D. E. J., Owen, M., Moss, H., Kelly, S., Donohoe, G., Murphy, K. C., Arango, C., Jahanshad, N., Thompson, P. M., Bearden, C. E. (2020). Altered white matter microstructure in 22q11.2 Deletion Syndrome: A multi-site diffusion tensor imaging study. Molecular Psychiatry, 25, 2818-2831. [LINK]
Sun, D., Ching, C. R. K., Lin, A., Forsyth, J. K., Kushan, L., Vajdi, A., Jalbrzikowski, M., Hansen, L., Villalon- Reina, J. E., Qu, X., Jonas, R. K., van Amelsvoort, T., Bakker, G., Kates, W. R., Antshel, K. M., Fremont, W., Campbell, L. E., McCabe, K. L. Daly, E., Gudbransen, M., Murphy, C. M., Murphy, D., Craig, M., Vorstman, J., Fiksinki, A., Koops, S., Ruparel, K., Roalf, D. R., Gur, R. E., Schmitt, J. E., Simon, T. J., Goodrich-Hunsaker, N. J., Durdle, C. A., Bassett, A. S., Chow, E. W. C., Butcher, N., Vila-Rodriguez, F., Doherty, J., Cunninghman, A., van den Bree, M., Linden, D. E. J., Moss, H., Owen, M. J., Murphy, K. C., McDonald-McGinn, D., Emanuel, B., van Erp, T. G., Turner, J. A., Thompson, P. M., Bearden, C. E. (2020). Large-scale mapping of cortical alterations in 22q11.2 Deletion Syndrome: Convergence with idiopathic psychosis and effects of deletion size. Molecular Psychiatry, 25, 1822-1834. [LINK]
2019
Gokhale, A., Freeman, A. A., Hartwig, C., Bassell, J. L., Zlatic, S. A., Sapp, C., Vadlamudi, T., Abudulai, F., Crocker, A., Werner, E., Wen, Z., Repetto, G. M., Gogos, J. A., Claypool, S. M., Forsyth, J. K., Bearden, C. E., Glausier, J., Lewis, D. A., Seyfried, N. T., Faundez, V. (2019). Systems analysis of the 22q11.2 microdeletion syndrome converges on a mitochondrial interactome necessary for synapse function and behavior. Journal of Neuroscience, 39(18), 3561-3581. [LINK]
2018
Cao H, Chen OY, Chung Y, Forsyth JK, McEwen S, Gee DG, Bearden CE, Addington J, Goodyear B, Cadenhead KS, Mirzakhanian H, Cornblatt BA, Carrion R, Mathalon DH, McGlashan TH, Perkins DO, Belger A, Seidman L, Thermenos HW, Tsuang MT, van Erp TGM, Walker EF, Hamann S, Anticevic A, Woods SW, Cannon TD. (2018). Cerebello-thalamo-cortical hyperconnectivity: a state-independent neural signature for psychosis prediction and characterization. Nature Communications, 9(1), 3836. [LINK]
Bearden, C. E., Forsyth, J. K. (2018). The many roads to psychosis: recent advances in understanding risk and mechanisms. F1000Research. 7:1883(F1000 Faculty Rev). https://doi.org:10.12688/f1000research.16574.1 [LINK]
Cao, H., McEwen, S. C., Forsyth, J. K., Gee, D. G., Bearden, C. E., Addington, J., Goodyear, B., Cadenhead, K. S., Mirzakhanian, H., Cornblatt, B. A., Carrion, R. E., Mathalon, D. H., McGlashan, T. H., Perkins, D. O., Belger, A., Seidman, L. J., Thermenos, H., Tsuang, M. T., van Erp, T. G. M., Walker, E. F., Hamann, S., Anticevic, A., Woods, S. W., Cannon, T. D. (2018). Toward leveraging human connectomic data in large consortia: Generalizability of fMRI-based brain graphs across sites, sessions, and paradigms. Cerebral Cortex, 10, 1263-1279. [LINK]
2017
Forsyth, J. K., Lewis, D. A. (2017). Mapping the consequences of impaired synaptic plasticity in schizophrenia through development: An integrative model for diverse clinical features. Trends in Cognitive Sciences, 21(10), 760-778. [LINK]
Forsyth, J. K., Bachman, P., Mathalon, D. M., Roach, B. J., Ye, E., Asarnow, R. F. (2017). Effects of augmenting N-Methyl-D-Aspartate receptor signaling on working memory and experience-dependent plasticity in schizophrenia: An exploratory study using acute d-cycloserine. Schizophrenia Bulletin, 43(5), 1123-1133. [LINK]
Cannon, T. D., Cao, H., Mathalon, D. H., Forsyth, J., NAPLS Consortium. (2017). Multisite reliability of fMRI measures of brain activation during working memory processing: Clarification and implications for statistical power. Neuroimage, 163, 456-458. [LINK]
Schreiner M*, Forsyth JK*, Karlsgodt KH, Anderson AE, Hirsh N, Kushan L, Uddin LQ, Mattiaccio L, Coman IL, Kates WR, Bearden CE. (2017). Intrinsic Connectivity Network-Based Classification and Detection of Psychotic Symptoms in Adolescents and Young Adults with 22q11.2 Deletions. Cerebral Cortex. 27(6):3294-3306. (*co-first author). [LINK]
2015
Forsyth, J. K., Bachman, P., Mathalon, D. M., Roach, B. J., Asarnow, R. F. (2015). Augmenting NMDA receptor signaling boosts experience-dependent plasticity in the adult human brain. Proceedings of the National Academy of Sciences, 112(50), 15331-15336. [LINK]
Gee, D. G., McEwen, S. C., Forsyth, J. K., Haut, K. M., Bearden, C. E., Addington, J., Goodyear, B., Cadenhead, K. S., Mirzakhanian, H., Cornblatt, B. A., Olvet, D., McGlashan, T. H., Perkins, D. O., Belger, A., Seidman, L. J., Thermenos, H., Tsuang, M. T., Walker, E. F., Hamann, S., Woods, S. W., Constable, T., Cannon, T. D. (2015). Reliability of an fMRI paradigm for emotional processing in a multi-site longitudinal study. Human Brain Mapping, 36(7), 2558-2579. [LINK]
2014
Forsyth, J. K., McEwen, S., Gee, D. G., Bearden, C. E., Addington, J., Goodyear, B., Cadenhead, K. S., Mirzakhanian, H., Cornblatt, B. A., Olvet, D., Mathalon, D., McGlashan, T. H., Perkins, D. O., Belger, A., Seidman, L. J., Thermenos, H., Tsuang, M. T., van Erp, T. G. M., Walker, E. F., Hamann, S., Woods, S. W., Qiu, M., Cannon, T. D. (2014). Reliability of functional magnetic resonance imaging activation during working memory in a multi-site study: Analysis from the North American Prodrome Longitudinal Study. Neuroimage, 97, 41-52. [LINK]
Bolbecker, A. R., Kent, J. S., Klaunig, M. J., Forsyth, J. K., Westfall, D. R., Howell, J. M., O’Donnell, B. F., Hetrick, W. P. (2014). Impaired cerebellar-dependent associative learning in first-degree relatives of individuals with schizophrenia. Schizophrenia Bulletin, 40(5), 1001-1010. [LINK]
2013
Asarnow, R. F, Forsyth, J. K. (2013). The genetics of childhood-onset schizophrenia. Child and Adolescent Psychiatric Clinics of North America, 22(4), 675–687. [LINK]
Forsyth JK, Ellman LM, Tanskanen A, Mustonen U, Huttunen M, Suvisaari J, Cannon TD. (2013). Genetic risk for schizophrenia, obstetric complications, and adolescent school outcome: Evidence for gene-environment interaction. Schizophrenia Bulletin. 39(5):1067-1076. [LINK]
2012
Rass, O., Forsyth, J. K., Krishnan, G., Hetrick, W. P., Klaunig, M., Breier, A., O’Donnell, B. F., Brenner, C. A. (2012). Auditory steady state response in schizophrenia, first-degree relatives, and schizotypal personality disorder. Schizophrenia Research, 136, 143-149. [LINK]
Rass, O., Forsyth, J. K., Bolbecker, A. R., Hetrick, W. P., Breier A., Lysaker, P., O’Donnell, B. F. (2012). Computer-assisted cognitive remediation for schizophrenia: A randomized single-blind study. Schizophrenia Research, 139, 92-98. [LINK]
Kent, J. S., Hong, S. L., Bolbecker, A. R., Klaunig, M. J., Forsyth, J. K., O’Donnell, B. F., Hetrick, W. P. (2012). Motor deficits in schizophrenia quantified by nonlinear analysis of postural sway. PLoS ONE 7(8), e41808. [LINK]
Forsyth, J. K., Bolbecker, A. R., Mehta, C. S., Klaunig, M. J., Steinmetz, J. E., O’Donnell, B. F., Hetrick, W. P. (2012). Cerebellar-dependent eyeblink conditioning deficits in schizophrenia spectrum disorders. Schizophrenia Bulletin, 38(4), 751-759. [LINK]
2011
Ahn, W-Y., Rass, O., Fridberg, D. J., Bishara, A. J., Forsyth, J. K., Breier, A., Busemeyer, J. R., Hetrick, W. P., Bolbecker, A. R., O’Donnell, B. F. (2011). Temporal discounting of rewards in patients with bipolar disorder and schizophrenia. Journal of Abnormal Psychology, 120(4), 911-921. [LINK]
Bolbecker, A. R., Steinmetz, A. B., Mehta, C. S., Forsyth, J. K., Klaunig, M. J., Lazar, E. K., Steinmetz, J. E., O’Donnell, B. F., Hetrick, W. P. (2011). Exploration of cerebellar-dependent associative learning in schizophrenia: Effects of varying and shifting interstimulus interval on eyeblink conditioning. Behavioral Neuroscience, 125(5), 687-698. [LINK]
Bolbecker, A. R., Hong, S. L., Kent, J. S., Forsyth, J. K., Klaunig, M. J., Lazar, E. K., O’Donnell, B. F., Hetrick, W. P. (2011). Paced finger-tapping abnormalities in bipolar disorder indicate timing dysfunction. Bipolar Disorders, 13(1), 99-110. [LINK]
2009
Beninger, R. J., Forsyth, J. K., Van Adel, M., Reynolds, J. N., Boegmam, R. J., Jhamandas, K. (2009). Subchronic MK-801 behavioral deficits in rats: Partial reversal by the novel nitrate GT 1061. Pharmacology, Biochemistry and Behavior, 91(4), 495-502. [LINK]
Beninger, R. J., Tuerke, K. J., Forsyth, J. K., Giles, A.C., Xue, L., Boegman, R. J., Jhamandas, K. (2009) Neonatal ventral hippocampal lesions in male and female rats: Effects on water maze, locomotor activity, plus-maze and prefrontal cortical GABA and glutamate release in adulthood. Behavioural Brain Research, 202(2), 198-209. [LINK]
